Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

Flunarizine in stroke treatment (FIST): a double-blind, placebo-controlled trial in Scandinavia and the Netherlands

(2010) C. L. Franke et al.   ACTA NEUROLOGICA SCANDINAVICA

Small Molecule Activation of Adaptive Gene Expression

(2010) Rajiv R. Ratan et al.   Annals of the New York Academy of Sciences

Overexpression of Heme Oxygenase-1 Is Neuroprotective in a Model of Permanent Middle Cerebral Artery Occlusion in Transgenic Mice

(2010) Nariman Panahian et al.   JOURNAL OF NEUROCHEMISTRY

Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain

(2009) Christina Schneider et al.   BRAIN RESEARCH

VEGF-A/VEGFR-2 Signaling Leading to cAMP Response Element-Binding Protein Phosphorylation Is a Shared Pathway Underlying the Protective Effect of Preconditioning on Neurons and Endothelial Cells

(2009) H.-T. Lee et al.   JOURNAL OF NEUROSCIENCE

Xenon Preconditioning Protects against Renal Ischemic-Reperfusion Injury via HIF-1  Activation

(2009) D. Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia

(2009) Emil Zeynalov et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effect of volatile anesthetic agents: molecular mechanisms

(2009) Gerald A. Matchett et al.   NEUROLOGICAL RESEARCH

Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model

(2009) M. Guerra-Crespo et al.   NEUROSCIENCE

Non-hypoxic Stabilization of Hypoxia-Inducible Factor Alpha (HIF-α): Relevance in Neural Progenitor/Stem Cells

(2009) Javorina Milosevic et al.   NEUROTOXICITY RESEARCH

Xenon and Sevoflurane Protect against Brain Injury in a Neonatal Asphyxia Model

(2008) Yan Luo et al.   ANESTHESIOLOGY

Antioxidants, HIF Prolyl Hydroxylase Inhibitors or Short Interfering RNAs to BNIP3 or PUMA, Can Prevent Prodeath Effects of the Transcriptional Activator, HIF-1α, in a Mouse Hippocampal Neuronal Line

(2008) Leila R. Aminova et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

(2008) Mária A. Deli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1α stabilization in the host brain

(2008) Kon Chu et al.   BRAIN RESEARCH

Isoflurane preconditioning activates HIF-1α, iNOS and Erk1/2 and protects against oxygen–glucose deprivation neuronal injury

(2008) Qi-fang Li et al.   BRAIN RESEARCH

Hypoxia-inducible factor (HIF)-1  directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

(2008) Z.-B. Han et al.   CARCINOGENESIS

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Vascular Endothelial Growth Factor and Angiopoietins in Neurovascular Regeneration and Protection Following Stroke

(2008) Tania Hansen et al.   CURRENT NEUROVASCULAR RESEARCH

Blood Brain Barrier in Hypoxic-Ischemic Conditions

(2008) C. Kaur et al.   CURRENT NEUROVASCULAR RESEARCH

The neuroprotection of prodromal transient ischaemic attack on cerebral infarction

(2008) Y. Fu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Glutamate preconditioning prevents neuronal death induced by combined oxygen–glucose deprivation in cultured cortical neurons

(2008) Chia-Ho Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain

(2008) Michelle Hedrick Theus et al.   EXPERIMENTAL NEUROLOGY

Tissue-type plasminogen activator as a therapeutic target in stroke

(2008) Iordanis Gravanis et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenomedullin protects neurons against oxygen glucose deprivation stress in an autocrine and paracrine manner

(2008) Emmanuelle Tixier et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain

(2008) Bastian Schönemeier et al.   JOURNAL OF NEUROIMMUNOLOGY

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis

(2008) Xinyang Hu et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin

(2008) Sarah K. Harten et al.   MOLECULAR BIOLOGY OF THE CELL

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

(2008) C. Rosenberger et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model

(2008) Wanqiu Chen et al.   NEUROBIOLOGY OF DISEASE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia

(2008) Zhao-Lu Wang et al.   NEUROSCIENCE LETTERS

Intranasal bFGF-induced progenitor cell proliferation and neuroprotection after transient focal cerebral ischemia

(2008) Yu-Ping Ma et al.   NEUROSCIENCE LETTERS

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

(2008) Nicole M Jones et al.   PEDIATRIC RESEARCH

The heme oxygenase inducer hemin protects against cardiac dysfunction and ventricular fibrillation in ischaemic/reperfused rat hearts: role of connexin 43

(2008) Päivi Lakkisto et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Delayed Tolerance With Repetitive Transient Focal Ischemic Preconditioning in the Mouse

(2008) Jian Zhang et al.   STROKE

DP-b99, a Membrane-Activated Metal Ion Chelator, as Neuroprotective Therapy in Ischemic Stroke

(2008) Hans-Christoph Diener et al.   STROKE

Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1α and erythropoietin

(2008) Yun-Xia Li et al.   Neuroscience Bulletin

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

(2007) E. Miles Whitman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY