IL-1–induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation

Individual T Helper Cells Have a Quantitative Cytokine Memory

(2015) Caroline Helmstetter et al.   IMMUNITY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy

(2015) Javad Rasouli et al.   JOURNAL OF IMMUNOLOGY

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

(2015) Rajatava Basu et al.   NATURE IMMUNOLOGY

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage

(2015) Andrew L. Croxford et al.   TRENDS IN IMMUNOLOGY

T-bet Expression by Foxp3+ T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis

(2015) Rhoanne C. McPherson et al.   Frontiers in Immunology

Microbial view of central nervous system autoimmunity

(2014) Kerstin Berer et al.   FEBS LETTERS

IL-1  Promotes the Differentiation of Polyfunctional Human CCR6+CXCR3+ Th1/17 Cells That Are Specific for Pathogenic and Commensal Microbes

(2014) T. Duhen et al.   JOURNAL OF IMMUNOLOGY

Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset

(2014) Dario Seppi et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebrospinal fluid detection of interleukin-1β in phase of remission predicts disease progression in multiple sclerosis

(2014) Silvia Rossi et al.   Journal of Neuroinflammation

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation

(2014) Chih-Chung Lin et al.   Nature Communications

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

(2014) Felix J. Hartmann et al.   Nature Communications

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

(2014) Aline Dumas et al.   PLoS Pathogens

CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+T cell response

(2013) Marc Martínez-Llordella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programmed Death-1 Shapes Memory Phenotype CD8 T Cell Subsets in a Cell-Intrinsic Manner

(2013) J. J. Charlton et al.   JOURNAL OF IMMUNOLOGY

microRNA-17-92 Regulates IL-10 Production by Regulatory T Cells and Control of Experimental Autoimmune Encephalomyelitis

(2013) D. de Kouchkovsky et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Pathogenicity of IFN- -Producing Th17 Cells Is Independent of T-bet

(2013) R. Duhen et al.   JOURNAL OF IMMUNOLOGY

Foxp3+Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production

(2012) Richard A. O'Connor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells in the central nervous system

(2012) Daniel E. Lowther et al.   IMMUNOLOGICAL REVIEWS

Pertussis Toxin Exacerbates and Prolongs Airway Inflammatory Responses during Bordetella pertussis Infection

(2012) Carey E. Connelly et al.   INFECTION AND IMMUNITY

IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway

(2012) Ujjal K. Bhawal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

(2012) Magdalena Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-Derived IL-1  Regulates the Production of GM-CSF by CD4+ T Cells and    T Cells

(2012) J. R. Lukens et al.   JOURNAL OF IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Inflammatory Gene Regulatory Networks in Amnion Cells Following Cytokine Stimulation: Translational Systems Approach to Modeling Human Parturition

(2011) Ruth Li et al.   PLoS One

GM-CSF Signalling Boosts Dramatically IL-1Production

(2011) Hanif Javanmard Khameneh et al.   PLoS One

IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis

(2010) C C Walline et al.   GENES AND IMMUNITY

Interleukin-1 Receptor Signaling Is Required To Overcome the Effects of Pertussis Toxin and for Efficient Infection- or Vaccination-Induced Immunity againstBordetella pertussis

(2010) Xuqing Zhang et al.   INFECTION AND IMMUNITY

The Role of the Basic Helix-Loop-Helix Transcription Factor Dec1 in the Regulatory T Cells

(2010) K. Miyazaki et al.   JOURNAL OF IMMUNOLOGY

Encephalitogenic T-cells increase numbers of CNS T-cells regardless of antigen specificity by both increasing T-cell entry and preventing egress

(2010) Jason R. Lees et al.   JOURNAL OF NEUROIMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis

(2009) E. E. McCandless et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

Pertussis Toxin Stimulates IL-17 Production in Response to Bordetella pertussis Infection in Mice

(2009) Charlotte Andreasen et al.   PLoS One

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

(2009) L. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

(2008) O. Feinerman et al.   SCIENCE