Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells

(2011) Patricia Sancho et al.   BIOCHEMICAL PHARMACOLOGY

IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling

(2011) Ángela M. Valverde et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

(2010) Rong Wang et al.   INTERNATIONAL JOURNAL OF CANCER

NADPH Oxidase NOX1 Controls Autocrine Growth of Liver Tumor Cells through Up-regulation of the Epidermal Growth Factor Receptor Pathway

(2010) Patricia Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snail1 suppresses TGF- -induced apoptosis and is sufficient to trigger EMT in hepatocytes

(2010) D. L. Franco et al.   JOURNAL OF CELL SCIENCE

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells

(2010) Laia Caja et al.   JOURNAL OF HEPATOLOGY

NGF-activated protein tyrosine phosphatase 1B mediates the phosphorylation and degradation of I-κ-Bα coupled to NF-κ-B activation, thereby controlling dendrite morphology

(2010) Pedro J. Chacón et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis

(2010) Matthew Stuible et al.   TRENDS IN CELL BIOLOGY

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF- -Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4

(2009) L. Caja et al.   CANCER RESEARCH

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli

(2009) Soledad Miranda et al.   CELLULAR SIGNALLING

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

Impairment of Transforming Growth Factor β Signaling in Caveolin-1-deficient Hepatocytes

(2009) Rafael Mayoral et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

(2008) Patricia Sancho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Multi-targeted therapy of cancer by genistein

(2008) Sanjeev Banerjee et al.   CANCER LETTERS

TGFβ in Cancer

(2008) Joan Massagué   CELL

Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

(2008) Cédric Coulouarn et al.   HEPATOLOGY

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

(2008) Irene Carmona-Cuenca et al.   JOURNAL OF HEPATOLOGY