Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin
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Title
Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin
Authors
Keywords
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Journal
CPT-Pharmacometrics & Systems Pharmacology
Volume 11, Issue 8, Pages 1060-1084
Publisher
Wiley
Online
2022-06-07
DOI
10.1002/psp4.12814
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- (2012) Yuri G. Anissimov et al. ADVANCED DRUG DELIVERY REVIEWS
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