Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

Use of normalized prediction distribution errors for assessing population physiologically-based pharmacokinetic model adequacy

(2020) Anil R. Maharaj et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Assessing pharmacokinetic differences in Caucasian and East Asian (Japanese, Chinese and Korean) populations driven by CYP2C19 polymorphism using physiologically-based pharmacokinetic modelling

(2019) Li Zhou et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and O-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling

(2019) Jeong et al.   Pharmaceutics

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

(2018) Mohamad Shebley et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

(2018) Bhagwat Prasad et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

(2018) Hidetoshi Shimizu et al.   DRUG METABOLISM AND DISPOSITION

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

(2014) Trevor N. Johnson et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

(2014) Farzaneh Salem et al.   CLINICAL PHARMACOKINETICS

In Silico Prediction of Percutaneous Absorption and Disposition Kinetics of Chemicals

(2014) Longjian Chen et al.   PHARMACEUTICAL RESEARCH

Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport

(2013) Catherine K. Yeung et al.   KIDNEY INTERNATIONAL

Improved input parameters for diffusion models of skin absorption

(2012) Steffi Hansen et al.   ADVANCED DRUG DELIVERY REVIEWS

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

(2012) Yuan Chen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Measuring the stratum corneum reservoir: Desorption kinetics from keratin

(2012) Salem Seif et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Modeling and predicting drug pharmacokinetics in patients with renal impairment

(2011) Karen Rowland Yeo et al.   Expert Review of Clinical Pharmacology

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

Older patients, multiple comorbidities, polymedication… should we treat everything?

(2010) N. Vogt-Ferrier   European Geriatric Medicine

A review of the clinical pharmacology of methamphetamine

(2009) Christopher C. Cruickshank et al.   ADDICTION

Stereoselectivity in the human metabolism of methamphetamine

(2009) Linghui Li et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Investigation of drug partition property in artificial sebum

(2007) Satyanarayana Valiveti et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS