The sarcomeric cytoskeleton: from molecules to motion

Nebulin, a multi-functional giant

(2016) Miensheng Chu et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance

(2016) FLEUR C. GARTON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Myopathic changes in murine skeletal muscle lacking synemin

(2015) Karla P. García-Pelagio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targets for therapy in sarcomeric cardiomyopathies

(2015) J. C. Tardiff et al.   CARDIOVASCULAR RESEARCH

Mechanotransduction in Cardiac Hypertrophy and Failure

(2015) R. C. Lyon et al.   CIRCULATION RESEARCH

CAPN3-mediated processing of C-terminal titin replaced by pathological cleavage in titinopathy

(2015) Karine Charton et al.   HUMAN MOLECULAR GENETICS

The Crystal Structure of the Human Titin:Obscurin Complex Reveals a Conserved yet Specific Muscle M-Band Zipper Module

(2015) Stefano Pernigo et al.   JOURNAL OF MOLECULAR BIOLOGY

Titin and Obscurin: Giants Holding Hands and Discovery of a New Ig Domain Subset

(2015) Guy M. Benian et al.   JOURNAL OF MOLECULAR BIOLOGY

Conserved expression of truncated telethonin in a patient with limb-girdle muscular dystrophy 2G

(2015) Rita Barresi et al.   NEUROMUSCULAR DISORDERS

Localization of Sarcomeric Proteins During Myofibril Assembly in Cultured Mouse Primary Skeletal Myotubes

(2014) Jennifer White et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Molecular Basis of the Mechanical Hierarchy in Myomesin Dimers for Sarcomere Integrity

(2014) Senbo Xiao et al.   BIOPHYSICAL JOURNAL

The Structure and Regulation of Human Muscle α-Actinin

(2014) Euripedes de Almeida Ribeiro et al.   CELL

α-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin

(2014) Bethany C. Prudner et al.   FEBS LETTERS

Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle

(2014) Mark A. Chapman et al.   HUMAN MOLECULAR GENETICS

Eccentric exercise: mechanisms and effects when used as training regime or training adjunct

(2014) Michael Vogt et al.   JOURNAL OF APPLIED PHYSIOLOGY

Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization

(2014) Stéphane Vassilopoulos et al.   JOURNAL OF CELL BIOLOGY

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy

(2014) Z. Li et al.   JOURNAL OF CELL SCIENCE

Force is a signal that cells cannot ignore

(2014) Erik C. Yusko et al.   MOLECULAR BIOLOGY OF THE CELL

The 3M Complex Maintains Microtubule and Genome Integrity

(2014) Jun Yan et al.   MOLECULAR CELL

G.P.34

(2014) C. Chauveau et al.   NEUROMUSCULAR DISORDERS

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

(2014) C. Long et al.   SCIENCE

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line

(2014) J. Bogomolovas et al.   Open Biology

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

(2014) Indroneal Banerjee et al.   PLoS Genetics

Phosphatidylinositol 4,5-bisphosphate regulates CapZβ1 and actin dynamics in response to mechanical strain

(2013) Jieli Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry

(2013) Seham Ebrahim et al.   CURRENT BIOLOGY

FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration

(2013) Thomas Iskratsch et al.   DEVELOPMENTAL CELL

Plectin–intermediate filament partnership in skin, skeletal muscle, and peripheral nerve

(2013) Maria J. Castañón et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

(2013) C. Chauveau et al.   HUMAN MOLECULAR GENETICS

CapZ and actin capping dynamics increase in myocytes after a bout of exercise and abates in hours after stimulation ends

(2013) Ying-Hsi Lin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac Myocytes

(2013) Alexandra J. Candasamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse

(2013) D. L. Yamamoto et al.   JOURNAL OF CELL SCIENCE

ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling

(2013) Jane T. Seto et al.   JOURNAL OF CLINICAL INVESTIGATION

A two-segment model for thin filament architecture in skeletal muscle

(2013) David S. Gokhin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The sarcomeric cytoskeleton as a target for pharmacological intervention

(2012) Ay Lin Kho et al.   CURRENT OPINION IN PHARMACOLOGY

A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart

(2012) M. Ibrahim et al.   HUMAN MOLECULAR GENETICS

Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties

(2012) Nikos Pinotsis et al.   PLOS BIOLOGY

Electron Microscopy and X-Ray Diffraction Evidence for Two Z-Band Structural States

(2011) Robert J. Perz-Edwards et al.   BIOPHYSICAL JOURNAL

Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart

(2011) Ralph Knöll et al.   CIRCULATION RESEARCH

Fast-folding  -helices as reversible strain absorbers in the muscle protein myomesin

(2011) F. Berkemeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An OBSL1-Cul7Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning

(2011) Nadia Litterman et al.   PLOS BIOLOGY

EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy

(2010) Roman Schoenauer et al.   BASIC RESEARCH IN CARDIOLOGY

The sarcomeric cytoskeleton: who picks up the strain?

(2010) Mathias Gautel   CURRENT OPINION IN CELL BIOLOGY

Interactions with M-band Titin and Calpain 3 Link Myospryn (CMYA5) to Tibial and Limb-girdle Muscular Dystrophies

(2010) Jaakko Sarparanta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and Dynamics of Myofibrils

(2010) Joseph W. Sanger et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance

(2010) Thomas Iskratsch et al.   JOURNAL OF CELL BIOLOGY

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle

(2010) P. Tonino et al.   JOURNAL OF CELL SCIENCE

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

(2010) Koichi Ojima et al.   JOURNAL OF CLINICAL INVESTIGATION

A Gene for Speed: The Emerging Role of α-Actinin-3 in Muscle Metabolism

(2010) Yemima Berman et al.   PHYSIOLOGY

The Giant Protein Titin as an Integrator of Myocyte Signaling Pathways

(2010) Wolfgang A. Linke et al.   PHYSIOLOGY

Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex

(2010) S. Pernigo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nebulin and N-WASP Cooperate to Cause IGF-1-Induced Sarcomeric Actin Filament Formation

(2010) K. Takano et al.   SCIENCE

CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms

(2009) Thomas J. Hartman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Nebulin Ruler Does Not Dictate Thin Filament Lengths

(2009) Angelica Castillo et al.   BIOPHYSICAL JOURNAL

Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere–membrane interaction, not sarcomere assembly

(2009) Ruilin Zhang et al.   HUMAN MOLECULAR GENETICS

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum

(2009) S. Lange et al.   JOURNAL OF CELL SCIENCE

The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling

(2009) Pradeep K. Luther   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Muscle Giants: Molecular Scaffolds in Sarcomerogenesis

(2009) Aikaterini Kontrogianni-Konstantopoulos et al.   PHYSIOLOGICAL REVIEWS

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk

(2009) M. Bertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band - implications for hereditary myopathies

(2008) A. Fukuzawa et al.   JOURNAL OF CELL SCIENCE

Nebulin Interacts with CapZ and Regulates Thin Filament Architecture within the Z-Disc

(2008) Christopher T. Pappas et al.   MOLECULAR BIOLOGY OF THE CELL

Thin filament length regulation in striated muscle sarcomeres: Pointed-end dynamics go beyond a nebulin ruler

(2008) R LITTLEFIELD et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tracking changes in Z-band organization during myofibrillogenesis with FRET imaging

(2008) Andrea L. Stout et al.   CELL MOTILITY AND THE CYTOSKELETON

Myomesin 3, a Novel Structural Component of the M-band in Striated Muscle

(2007) Roman Schoenauer et al.   JOURNAL OF MOLECULAR BIOLOGY