Muscle Giants: Molecular Scaffolds in Sarcomerogenesis

Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties

(2009) David S. Gokhin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency

(2009) C. A.C. Ottenheijm et al.   HUMAN MOLECULAR GENETICS

Single Molecule Force Spectroscopy of the Cardiac Titin N2B Element

(2009) Yi Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin

(2009) M. Coisy-Quivy et al.   JOURNAL OF CELL SCIENCE

Titin-based mechanical signalling in normal and failing myocardium

(2009) Martina Krüger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A LIM-9 (FHL) / SCPL-1 (SCP) Complex Interacts with the C-terminal Protein Kinase Regions of UNC-89 (Obscurin) in Caenorhabditis elegans Muscle

(2009) Ge Xiong et al.   JOURNAL OF MOLECULAR BIOLOGY

Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears

(2008) O. Lynne Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myasthenia Gravis Seronegative for Acetylcholine Receptor Antibodies

(2008) Angela Vincent et al.   Annals of the New York Academy of Sciences

Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-terminus

(2008) Min-A Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

(2008) Martina Krüger et al.   CIRCULATION RESEARCH

Giant Proteins: Sensing Tension with Titin Kinase

(2008) Larissa Tskhovrebova et al.   CURRENT BIOLOGY

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

(2008) Coen A. C. Ottenheijm et al.   FASEB JOURNAL

Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres

(2008) Emiliana Giacomello et al.   HISTOCHEMISTRY AND CELL BIOLOGY

New aspects of obscurin in human striated muscles

(2008) Lena Carlsson et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Early incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesis

(2008) Andrei B. Borisov et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Multiple Molecular Interactions Implicate the Connectin/Titin N2A Region as a Modulating Scaffold for p94/Calpain 3 Activity in Skeletal Muscle

(2008) Chikako Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obscurin Targets Ankyrin-B and Protein Phosphatase 2A to the Cardiac M-line

(2008) Shane R. Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band - implications for hereditary myopathies

(2008) A. Fukuzawa et al.   JOURNAL OF CELL SCIENCE

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

(2008) Farah Sheikh et al.   JOURNAL OF CLINICAL INVESTIGATION

The DH-PH Region of the Giant Protein UNC-89 Activates RHO-1 GTPase in Caenorhabditis elegans Body Wall Muscle

(2008) Hiroshi Qadota et al.   JOURNAL OF MOLECULAR BIOLOGY

Physiological Functions of the Giant Elastic Protein Titin in Mammalian Striated Muscle

(2008) Norio Fukuda et al.   Journal of Physiological Sciences

The Rho-Guanine Nucleotide Exchange Factor Domain of Obscurin Regulates Assembly of Titin at the Z-Disk through Interactions with Ran Binding Protein 9

(2008) Amber L. Bowman et al.   MOLECULAR BIOLOGY OF THE CELL

Nebulin Interacts with CapZ and Regulates Thin Filament Architecture within the Z-Disc

(2008) Christopher T. Pappas et al.   MOLECULAR BIOLOGY OF THE CELL

A Novel Protein Phosphatase is a Binding Partner for the Protein Kinase Domains of UNC-89 (Obscurin) in Caenorhabditis elegans

(2008) Hiroshi Qadota et al.   MOLECULAR BIOLOGY OF THE CELL

Truncating mutations in C-terminal titin may cause more severe tibial muscular dystrophy (TMD)

(2008) Peter Hackman et al.   NEUROMUSCULAR DISORDERS

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

(2008) E. von Castelmur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dynamic Z Bands of Striated Muscle Cells

(2008) J. M. Sanger et al.   Science Signaling

Thin filament length regulation in striated muscle sarcomeres: Pointed-end dynamics go beyond a nebulin ruler

(2008) R LITTLEFIELD et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells

(2007) Andrei B. Borisov et al.   JOURNAL OF CELLULAR BIOCHEMISTRY