Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach

Fluorinated Sulfinates as Source of Alkyl Radicals in the Photo‐Enantiocontrolled β‐Functionalization of Enals

(2022) Ricardo I. Rodríguez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrochemical Tri‐ and Difluoromethylation‐Triggered Cyclization Accompanied by the Oxidative Cleavage of Indole Derivatives

(2021) Xin Yuan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Enantioselective Difluoromethylation of Amino Acids via Difluorocarbene

(2021) Lingzi Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Molecular Photoelectrochemistry: New Frontiers in Synthetic Applications, Mechanistic Insights and Scalability

(2021) Shangze Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electro‐mediated PhotoRedox Catalysis for Selective C(sp 3 )–O Cleavages of Phosphinated Alcohols to Carbanions

(2021) Xianhai Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aryl Radical Activation of C–O Bonds: Copper-Catalyzed Deoxygenative Difluoromethylation of Alcohols

(2021) Aijie Cai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical C−C bond cleavage of cyclopropanes towards the synthesis of 1,3-difunctionalized molecules

(2021) Pan Peng et al.   Nature Communications

Organozinc pivalates for cobalt-catalyzed difluoroalkylarylation of alkenes

(2021) Xinyi Cheng et al.   Nature Communications

Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

(2021) Aijie Cai et al.   Nature Communications

Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis

(2021) Naish Lalloo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photochemical C–F Activation Enables Defluorinative Alkylation of Trifluoroacetates and -Acetamides

(2021) Mark W. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides

(2021) Zhenlei Zou et al.   ORGANIC LETTERS

Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles

(2021) Heyun Sheng et al.   ORGANIC LETTERS

Reductive Electrophotocatalysis: Merging Electricity and Light To Achieve Extreme Reduction Potentials

(2020) Hyunwoo Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

General C(sp2)-C(sp3) Cross-Electrophile Coupling Reactions Enabled by Overcharge Protection of Homogeneous Electrocatalysts

(2020) Blaise L. Truesdell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

(2020) Wei Zhang et al.   Nature Communications

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

(2020) Jeroen B. I. Sap et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrode Materials in Modern Organic Electrochemistry

(2020) David Heard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photosensitized direct C–H fluorination and trifluoromethylation in organic synthesis

(2020) Shahboz Yakubov et al.   Beilstein Journal of Organic Chemistry

Sila-Ibuprofen

(2020) Florian Kleemiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Silver‐Enabled General Radical Difluoromethylation Reaction with TMSCF 2 H

(2020) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Electroreductive Approach to Radical Silylation via the Activation of Strong Si–Cl Bond

(2020) Lingxiang Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electroreductive Olefin–Ketone Coupling

(2020) Pengfei Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electroreductive Carbofunctionalization of Alkenes with Alkyl Bromides via a Radical-Polar Crossover Mechanism

(2020) Wen Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry

(2019) Byron K. Peters et al.   SCIENCE

Visible-Light-Induced Radical Di- and Trifluoromethylation of β, γ-Unsaturated Oximes: Synthesis of Di- and Trifluoromethylated Isoxazolines

(2019) Mei Zhu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Electrochemical Difluoromethylation of Electron-Deficient Alkenes

(2019) He-Huan Xu et al.   ChemSusChem

A General C-H Difluoromethylation Protocol for Carbon Acids Using TMSCF2Br

(2019) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid

(2019) Claudio F. Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?

(2019) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators

(2019) Chih-Chung Tseng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Decarboxylative Difluoromethylation

(2019) Xiaojun Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Electroreductive Coupling of Alkenyl and Benzyl Halides via Nickel Catalysis

(2019) Travis J. DeLano et al.   ACS Catalysis

Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes

(2019) Xia-Ping Fu et al.   Nature Chemistry

Recent Progress on the Synthesis of CF2H-Containing Derivatives

(2019) Noam Levi et al.   SYNTHESIS-STUTTGART

Copper-Catalyzed, Chloroamide-Directed Benzylic C–H Difluoromethylation

(2019) Xiaojun Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Photoelectrochemistry

(2019) Joshua Philip Barham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

(2018) Wenjun Miao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical Difluoromethylarylation of Alkynes

(2018) Peng Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free Electrocatalytic Aerobic Hydroxylation of Arylboronic Acids

(2018) Jian Luo et al.   ORGANIC LETTERS

Redox-neutral tri-/difluoromethylation of para-quinone methides with sodium sulfinates

(2018) Qing-Yan Wu et al.   Organic Chemistry Frontiers

New Horizons of Photocatalytic Fluoromethylative Difunctionalization of Alkenes

(2018) Takashi Koike et al.   Chem

Direct and Regioselective C–H Oxidative Difluoromethylation of Heteroarenes

(2018) Sheng-Qing Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Docking-Migration Strategy for Selective Radical Difluoromethylation of Alkenes

(2018) Jiajia Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

Visible-light induced di- and trifluoromethylation of N-benzamides with fluorinated sulfones for the synthesis of CF2H/CF3-containing isoquinolinediones

(2017) Guanglong Zou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

(2017) Robert J. Perkins et al.   ORGANIC LETTERS

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes

(2017) James R. Bour et al.   ORGANOMETALLICS

Multielectron, multisubstrate molecular catalysis of electrochemical reactions: Formal kinetic analysis in the total catalysis regime

(2017) Cyrille Costentin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

(2016) Jian Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bis(difluoromethyl)trimethylsilicate Anion: A Key Intermediate in Nucleophilic Difluoromethylation of Enolizable Ketones with Me3 SiCF2 H

(2016) Dingben Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant

(2016) Hong Yi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Photoredox-Catalyzed Reductive Difluoromethylation of Electron-Deficient Alkenes

(2015) Xiao-Jun Tang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols

(2015) Yusuke Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorine in Drug Design: A Case Study with Fluoroanisoles

(2015) Li Xing et al.   ChemMedChem

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Redox catalysis in organic electrosynthesis: basic principles and recent developments

(2014) Robert Francke et al.   CHEMICAL SOCIETY REVIEWS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Difluoro- and Trifluoromethylation of Electron-Deficient Alkenes in an Electrochemical Microreactor

(2013) Kenta Arai et al.   ChemistryOpen

Tuning the Reactivity of Difluoromethyl Sulfoximines from Electrophilic to Nucleophilic: Stereoselective Nucleophilic Difluoromethylation of Aryl Ketones

(2012) Xiao Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Understanding Fluorine Effects in Liquid Crystals

(2009) Peer Kirsch et al.   CHEMPHYSCHEM

Super-Fluorinated Liquid Crystals: Towards the Limits of Polarity

(2008) Peer Kirsch et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS