The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing

Targeting abnormal Nrf2/HO-1 signaling in amyotrophic lateral sclerosis: Current Insights on drug targets and influences on neurological disorders

(2021) Elizabeth Minj et al.   CURRENT MOLECULAR MEDICINE

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

(2021) Xinxin Zuo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp90 and its co‐chaperone Sti1 control TDP‐43 misfolding and toxicity

(2021) Lilian Tsai‐Wei Lin et al.   FASEB JOURNAL

The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS

(2021) Jasmine Harley et al.   Antioxidants

Mechanisms of TDP-43 Proteinopathy Onset and Propagation

(2021) Han-Jou Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TDP-43 and ER Stress in Neurodegeneration: Friends or Foes?

(2021) Lorena de Mena et al.   Frontiers in Molecular Neuroscience

Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation

(2020) Hang Yu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases

(2020) Rose Ghemrawi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis

(2020) HaEun Cho et al.   Pharmaceuticals

Edaravone reduces Aβ-induced oxidative damage in SH-SY5Y cells by activating the Nrf2/ARE signaling pathway

(2019) Lei Zhang et al.   LIFE SCIENCES

An FTLD-associated SQSTM1 variant impacts Nrf2 and NF-κB signalling and is associated with reduced phosphorylation of p62

(2019) A. Foster et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation

(2019) Man Zhang et al.   Experimental and Therapeutic Medicine

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

(2019) Zhiqiang Deng et al.   Autophagy

Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS

(2019) Giovanna Morello et al.   Scientific Reports

The expanding spectrum of neurological disorders of phosphoinositide metabolism

(2019) Jonathan R. Volpatti et al.   Disease Models & Mechanisms

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro

(2019) Takujiro Homma et al.   EXPERIMENTAL CELL RESEARCH

How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

(2018) Kazutoshi Watanabe et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Edaravone Reduces Iron-Mediated Hydrocephalus and Behavioral Disorder in Rat by Activating the Nrf2/HO-1 Pathway

(2018) Jianbo Zhang et al.   Journal of Stroke & Cerebrovascular Diseases

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

(2018) Manoj Kumar Jaiswal   MEDICINAL RESEARCH REVIEWS

Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis

(2018) Yasuyuki Ohta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of mutant TDP-43 on the Nrf2/ARE pathway and protein expression of MafK and JDP2 in NSC-34 cells

(2017) Y.P. Tian et al.   GENETICS AND MOLECULAR RESEARCH

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Edaravone attenuates oxidative stress induced by chronic cerebral hypoperfusion injury: role of ERK/Nrf2/HO-1 signaling pathway

(2017) Dandan Zhang et al.   NEUROLOGICAL RESEARCH

Edaravone and its clinical development for amyotrophic lateral sclerosis

(2017) Koji Takei et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

(2017) Christopher P. Webster et al.   Frontiers in Molecular Neuroscience

Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function

(2017) Bernadett Kalmar et al.   Frontiers in Molecular Neuroscience

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging

(2017) Tomohiro Ishii et al.   PLoS One

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

(2016) Daniel Cacabelos et al.   NEUROBIOLOGY OF DISEASE

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress

(2015) Mohammad-Saeid Jami et al.   NEUROCHEMISTRY INTERNATIONAL

Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse

(2015) Ken Ikeda et al.   PLoS One

An acetylation switch controls TDP-43 function and aggregation propensity

(2015) Todd J. Cohen et al.   Nature Communications

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Edaravone protects against glutamate-induced PERK/EIF2α/ATF4 integrated stress response and activation of caspase-12

(2013) Jin Fan et al.   BRAIN RESEARCH

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

(2013) Chung-ke Chang et al.   FEBS LETTERS

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo

(2013) Kazuhiko Watabe et al.   NEUROPATHOLOGY

Redox Regulation in Amyotrophic Lateral Sclerosis

(2013) Sonam Parakh et al.   Oxidative Medicine and Cellular Longevity

Edaravone Protects HT22 Neurons from H2O2-induced Apoptosis by Inhibiting the MAPK Signaling Pathway

(2012) Zhong-Yan Zhao et al.   CNS Neuroscience & Therapeutics

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger

(2011) Masashi Aoki et al.   BRAIN RESEARCH

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

(2011) Todd J Cohen et al.   EMBO JOURNAL

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

(2011) Yohei Iguchi et al.   NEUROBIOLOGY OF DISEASE

Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1

(2010) Owen A. Brady et al.   JOURNAL OF NEUROCHEMISTRY

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture

(2009) Kenjiro Hisano et al.   Journal of Anesthesia

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

(2009) Y.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

(2008) Hidefumi Ito et al.   EXPERIMENTAL NEUROLOGY