Direct targeted therapy for MLL‐fusion‐driven high‐risk acute leukaemias

MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

(2022) Sarah Naomi Olsen et al.   MOLECULAR CELL

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

(2021) Stefanie Meier et al.   Cell Death & Disease

Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study

(2019) Rob Pieters et al.   JOURNAL OF CLINICAL ONCOLOGY

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

(2019) Andrei V. Krivtsov et al.   CANCER CELL

Targeted therapy for fusion-driven high-risk acute leukemia

(2018) Yana Pikman et al.   BLOOD

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial

(2018) Sulggi A. Lee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

(2018) Xiaorong Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

(2017) V Walf-Vorderwülbecke et al.   LEUKEMIA

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia

(2017) K H M Prange et al.   ONCOGENE

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

(2017) Jon Kerry et al.   Cell Reports

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia

(2016) D Pal et al.   LEUKEMIA

Targeted Therapy Alone for Acute Promyelocytic Leukemia

(2016) Francesco Lo-Coco et al.   NEW ENGLAND JOURNAL OF MEDICINE

fluff: exploratory analysis and visualization of high-throughput sequencing data

(2016) Georgios Georgiou et al.   PeerJ

Tyrosine kinase inhibitors in BCR-ABL positive acute lymphoblastic leukemia

(2015) V. Leoni et al.   HAEMATOLOGICA

The Mechanochemistry of a Structural Zinc Finger

(2015) Judit Perales-Calvo et al.   Journal of Physical Chemistry Letters

Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial

(2015) Alan K Burnett et al.   LANCET ONCOLOGY

Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β

(2015) Vikas Sharma et al.   MOLECULAR CARCINOGENESIS

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

(2015) Jae-Seok Roe et al.   MOLECULAR CELL

A Phase IIb Trial Assessing the Addition of Disulfiram to Chemotherapy for the Treatment of Metastatic Non-Small Cell Lung Cancer

(2015) H. Nechushtan et al.   ONCOLOGIST

Tyrosine kinase inhibitors in BCR-ABL positive acute lymphoblastic leukemia

(2015) V. Leoni et al.   HAEMATOLOGICA

Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo

(2015) Peng Liu et al.   Oncotarget

Site-specific human histone H3 methylation stability: fast K4me3 turnover

(2014) Yupeng Zheng et al.   PROTEOMICS

NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function

(2014) S. M. Gough et al.   Cancer Discovery

Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells

(2013) Ameya Paranjpe et al.   CARCINOGENESIS

Functional Specificity of CpG DNA-binding CXXC Domains in Mixed Lineage Leukemia

(2013) Laurie E. Risner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites

(2013) Yupeng Zheng et al.   Nature Communications

The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability

(2013) Ana Lúcia Vargas Arigony et al.   Biomed Research International

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

(2012) Jolanta Grembecka et al.   Nature Chemical Biology

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

Leukemia stem cells

(2011) Eike C. Buss et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

The Drug-Induced Degradation of Oncoproteins: An Unexpected Achilles' Heel of Cancer Cells?

(2011) Julien Ablain et al.   Cancer Discovery

Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)

(2010) T. P. Hughes et al.   BLOOD

Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12

(2010) Christine J. Harrison et al.   JOURNAL OF CLINICAL ONCOLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

(2010) Jianqing Lin et al.   PROSTATE

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

(2009) Harukazu Suzuki et al.   NATURE GENETICS

Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

(2009) Tomasz Cierpicki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression

(2009) M. Tariq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

(2008) S. J. Horton et al.   BLOOD

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

(2008) H. Kroeger et al.   BLOOD

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

(2008) M. G. Guenther et al.   GENES & DEVELOPMENT

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY