Functional Specificity of CpG DNA-binding CXXC Domains in Mixed Lineage Leukemia

The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain

(2011) Chao Xu et al.   Nature Communications

Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study

(2010) G. Mann et al.   BLOOD

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis

(2010) Thomas A. Milne et al.   MOLECULAR CELL

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

(2009) Tomasz Cierpicki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression

(2008) F. E. Erfurth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA