Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

(2022) Ziena Abdulrahman et al.   Journal for ImmunoTherapy of Cancer

Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy

(2021) Kim M. van Pul et al.   Frontiers in Immunology

A Palette of Cytokines to Measure Anti-Tumor Efficacy of T Cell-Based Therapeutics

(2021) Prathyaya Ramesh et al.   Cancers

Design of PD-1-decorated nanocages targeting tumor-draining lymph node for promoting T cell activation

(2021) Gi Beom Kim et al.   JOURNAL OF CONTROLLED RELEASE

Safety and Feasibility of Radiotherapy Plus Camrelizumab for Locally Advanced Esophageal Squamous Cell Carcinoma

(2021) Wencheng Zhang et al.   ONCOLOGIST

Ribosylation of the CD8αβ heterodimer permits binding of the non-classical major histocompatibility molecule, H2-Q10

(2021) Katharine Jennifer Goodall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advancing to the era of cancer immunotherapy

(2021) Yun Wang et al.   Cancer Communications

ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

(2021) Yuanqin Yang et al.   Science Advances

Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates

(2021) Shijie Shang et al.   Cancer Communications

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

(2020) Khalil S. Rawji et al.   ACTA NEUROPATHOLOGICA

The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity

(2020) Alexandra Schnell et al.   CELL RESEARCH

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing

(2020) Jun-Bao Fan et al.   Cancer Discovery

Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy

(2020) Filippo Galli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation

(2020) Minhui Chen et al.   Nature Communications

SHP-2 and PD-L1 inhibition combined with radiotherapy enhances systemic antitumor effects in an anti-PD-1-resistant model of non-small-cell lung cancer

(2020) Dawei Chen et al.   Cancer Immunology Research

The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes

(2020) Floris Dammeijer et al.   CANCER CELL

Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy

(2020) Zachary S Buchwald et al.   Journal for ImmunoTherapy of Cancer

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

(2020) Sri Krishna et al.   SCIENCE

CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

(2020) Man Zhang et al.   Nature Communications

Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy

(2020) Amy J. Wisdom et al.   Nature Communications

Role of lymph node stroma and microenvironment in T cell tolerance

(2019) Vikas Saxena et al.   IMMUNOLOGICAL REVIEWS

Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

(2019) Stephanie O. Dudzinski et al.   Journal for ImmunoTherapy of Cancer

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

(2019) June-Yong Lee et al.   CELL

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy

(2018) Ariel E. Marciscano et al.   CLINICAL CANCER RESEARCH

Abscopal Effects With Hypofractionated Schedules Extending Into the Effector Phase of the Tumor-Specific T-Cell Response

(2018) Xuanwei Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

(2018) María E. Rodríguez-Ruiz et al.   TRENDS IN IMMUNOLOGY

Abscopal effect of radiotherapy combined with immune checkpoint inhibitors

(2018) Yang Liu et al.   Journal of Hematology & Oncology

Time to abandon single-site irradiation for inducing abscopal effects

(2018) Eric D. Brooks et al.   Nature Reviews Clinical Oncology

Structural alterations in tumor-draining lymph nodes before papillary thyroid carcinoma metastasis

(2017) Andrew M. Hinson et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

(2017) David Druzd et al.   IMMUNITY

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

(2017) Yulei Chen et al.   Journal of Hematology & Oncology

Radiotherapy and immunotherapy: a beneficial liaison?

(2017) Ralph R. Weichselbaum et al.   Nature Reviews Clinical Oncology

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

(2017) Hua Liang et al.   Nature Communications

Lymph node - an organ for T-cell activation and pathogen defense

(2016) Georg Gasteiger et al.   IMMUNOLOGICAL REVIEWS

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade

(2015) Frederick J Kohlhapp et al.   Journal for ImmunoTherapy of Cancer

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

(2014) A. B. Sharabi et al.   Cancer Immunology Research

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

(2014) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Local Radiation Therapy Inhibits Tumor Growth through the Generation of Tumor-Specific CTL: Its Potentiation by Combination with Th1 Cell Therapy

(2010) Tsuguhide Takeshima et al.   CANCER RESEARCH