Article
Chemistry, Multidisciplinary
Liwei Jiang, Sungwook Jung, Jing Zhao, Vivek Kasinath, Takaharu Ichimura, John Joseph, Paolo Fiorina, Andrew S. Liss, Khalid Shah, Nasim Annabi, Nitin Joshi, Tomoya O. Akama, Jonathan S. Bromberg, Motohiro Kobayashi, Kenji Uchimura, Reza Abdi
Summary: The newly developed MHA112-Taxol drug delivery platform can simultaneously target tumors, TDLNs, and metastatic lesions, effectively reducing the size of primary tumors and the number of metastatic lesions.
Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dante Alexander Patrick Louie, Darellynn Oo, Glory Leung, Yujia Lin, Matthew Stephens, Omar Alrashed, Marcus Tso, Shan Liao
Summary: Lymph node metastasis is closely related to tumor aggressiveness and poor prognosis. Research has shown that both anti-tumor and exhausted tumor-specific T cells can be induced in the tumor-draining lymph node (TDLN), but the activation and maturation of B cells in the TDLN have received less attention. In this study using mouse models, it was found that tumor growth promotes the entry of tumor-associated antigens into the B cell zone and facilitates access to follicular dendritic cells (FDCs) in the germinal centers (GCs), where antigen-specific B cell maturation occurs. Depletion of subcapsular sinus (SCS) macrophages in the TDLN increased GC formation and promoted tumor growth. These findings suggest that TDLN reconstruction creates a niche that favors B cell activation and maturation during tumor growth.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qizhao Huang, Xia Wu, Zhiming Wang, Xiangyu Chen, Lisha Wang, Yijun Lu, Dan Xiong, Qiao Liu, Yuhan Tian, Huayu Lin, Junyi Guo, Shuqiong Wen, Wei Dong, Xiaofan Yang, Yuchen Yuan, Zhengliang Yue, Shun Lei, Qing Wu, Ling Ran, Luoyingzi Xie, Yifei Wang, Leiqiong Gao, Qin Tian, Xinyuan Zhou, Beicheng Sun, Lifan Xu, Zhonghui Tang, Lilin Ye
Summary: Blocking PD-1/PD-L1 signaling can unleash tumor-specific CD8+ T cells in the tumor draining lymph nodes and enhance anti-tumor therapeutic efficacy.
Article
Oncology
Yoonki Heo, Eunbyeol Ko, Sejung Park, Si-On Park, Byung-Cheol Ahn, Jung-Sun Yum, Eunyoung Chun
Summary: L-pampo is an innovative adjuvant system containing TLR2 and TLR3 agonists, which induces strong immune responses. It directly stimulates the maturation and function of dendritic cells, leading to antigen-specific T-cell responses and potent anti-tumor effects. Combining L-pampo with immune checkpoint inhibitors synergistically improves the anti-tumor effect.
Article
Oncology
Meghan J. O'Melia, Margaret P. Manspeaker, Susan N. Thomas
Summary: This study explores the potential for antitumor CD8(+) T cell immunity in lymphoid tissues in TNBC, identifying tumor-draining lymph nodes (TdLNs) as a unique potential tumor immunity reservoir supporting CD8(+) T lymphocytes' survival and antigenic priming. Strategies targeting TdLNs may improve the effects of immune checkpoint blockade (ICB) immunotherapy in TNBC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Mengwen Huang, Songrong Wang, Senbiao Chen, Jilong Wang, Congfei Xu, Jing Liu, Zhexiong Lian, Xiaojiao Du, Jun Wang
Summary: In this study, the effects of pegylated liposomal mitoxantrone (PL-MIT) on tumor immune landscape were investigated. PL-MIT was found to enhance multiple damage-associated molecule patterns (DAMPs) signals in tumors, promote dendritic cells maturation and T cells infiltration, and induce high expression of PD-L1 on myeloid-derived suppressor cells (MDSC), which negatively impacts antitumor immunity.
Article
Oncology
Alexander J. Najibi, Ting-Yu Shih, David K. Y. Zhang, Junzhe Lou, Miguel C. Sobral, Hua Wang, Maxence O. Dellacherie, Kwasi Adu-Berchie, David J. Mooney
Summary: Disruption of the tumor extracellular matrix may alter immune cell infiltration and T cell responses in tumor-draining lymph nodes. In this study, we explore how enzyme treatment can enhance antigen presentation and T cell responses in the lymph nodes, supporting the generation of tumor-specific immunity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Engineering, Biomedical
Jie Chen, Huapan Fang, Yingying Hu, Jiayan Wu, Sijia Zhang, Yuanji Feng, Lin Lin, Huayu Tian, Xuesi Chen
Summary: This study explores an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines with gene regulated PD-L1 blockade. The mannose modified nanovaccines can effectively co-encapsulate antigen and adjuvant, promoting endocytosis and cross presentation in dendritic cells. However, the limited inhibition of tumor growth by nanovaccines in the immunosuppressed tumor microenvironment can be overcome by combining with gene regulated PD-L1 blockade, leading to significant tumor remission.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yekkuni L. Balachandran, Xuanyu Li, Xingyu Jiang
Summary: This study developed an integrated microfluidic chip to synthesize aptamer-modified biozeolitic imidazolate framework for targeting lymph nodes and tumors. The approach reduced synthesis time, encapsulated more biomolecules, and realized the rapid and fine-tuned synthesis of functional MOFs in one step.
Review
Biochemistry & Molecular Biology
Marieke F. Fransen, Thorbald van Hall, Ferry Ossendorp
Summary: Lymph nodes play a crucial role in immune responses, but the resection of tumor-draining lymph nodes needs to be reevaluated. Recent studies suggest that tumor-draining lymph nodes may play an important role in cancer immunotherapy, potentially changing the use of immune checkpoint therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yasuhiro Kanda, Taku Okazaki, Tomoya Katakai
Summary: This review discusses the importance of T cell dynamics and immune responses in tumor-draining lymph nodes (TDLNs) under immune checkpoint blockade (ICB) therapy, emphasizing the alteration of T cell motility. Studying T cell dynamics in TDLNs can provide a good indicator for evaluating the efficacy of antitumor therapy using ICB, showcasing the significance of T cell migration in adaptive immune responses.
Article
Medicine, Research & Experimental
Alina D. Lam, Ian K. Styles, Danielle Senyschyn, Enyuan Cao, Abel Anshabo, Mohammad Abdallah, Reyaj Mikrani, Cameron J. Nowell, Christopher J. H. Porter, Orlagh M. Feeney, Natalie L. Trevaskis
Summary: Changes in immune cells within the joint-draining lymphatics contribute to the progression of inflammatory arthritis. There is an expansion of pathogenic B cells in the joint-draining lymph node, which inhibit lymph flow and reduce clearance of inflammatory fluid and cells. Localized delivery of B-cell depleting therapies to the joint-draining lymph nodes has the potential to improve treatment efficacy and reduce side effects.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Jaeseong Lee, Sungtaek Kang, Hyeseon Park, Jeong Gil Sun, Eun Chae Kim, Gayong Shim
Summary: Lymph nodes are important organs that control immune cells and provide a pathway for tumors to spread. Nanoparticles offer several advantages for effective lymphatic delivery, including tailored size for migration and targeting of specific cells. Existing contrast agents are not able to selectively target metastatic lymph nodes, but nanoparticles can achieve this goal. Additionally, functionalized nanoparticles can deliver anticancer drugs to metastatic lymph nodes. This review discusses the use of nanoparticles for lymphatic mapping and highlights design considerations for detecting metastatic lymph nodes. Future directions for lymph node-targeting nanoparticles are also suggested.
Article
Polymer Science
Airi Harui, Michael D. Roth
Summary: In this study, peri-tumor administration of hydrogel-encapsulated anti-CTLA-4 was found to specifically target tumor-draining lymph nodes, and the inclusion of hyaluronidase enhanced this targeting effect. These findings provide a theoretical basis for further optimizing immunotherapy.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)