HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets

Chemogenomic and bioinformatic profiling of ERdj paralogs underpins their unique roles in cancer

(2022) Laura E. Knighton et al.   CELL STRESS & CHAPERONES

Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

(2021) Francis Kayamba et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

(2021) Tatyana Almeida Tavella et al.   ACS Infectious Diseases

Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1

(2021) Nicolaas Salomane et al.   CELL STRESS & CHAPERONES

Structures of the Plasmodium falciparum heat-shock protein 70-x ATPase domain in complex with chemical fragments identify conserved and unique binding sites

(2021) Nada Mohamad et al.   Acta Crystallographica Section F-Structural Biology Communications

Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

(2021) Mathias Diehl et al.   PLoS Pathogens

Structure of the substrate-binding domain of Plasmodium falciparum heat-shock protein 70-x

(2020) Julia Schmidt et al.   Acta Crystallographica Section F-Structural Biology Communications

Exported plasmodial J domain protein, PFE0055c, and PfHsp70-x form a specific co-chaperone-chaperone partnership

(2020) Tanima Dutta et al.   CELL STRESS & CHAPERONES

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

(2019) Heather M. Kudyba et al.   CELLULAR MICROBIOLOGY

Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence

(2019) Michael O. Daniyan et al.   Biomolecules

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite

(2019) Jemma Day et al.   FASEB JOURNAL

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

(2018) Michael A. Moses et al.   CANCER RESEARCH

Structural heterogeneity and dynamics in protein evolution and design

(2018) Kristoffer E Johansson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)

(2018) Hao Shao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

Isolation, characterization, and biological evaluation of a potent anti-malarial drimane sesquiterpene from Warburgia salutaris stem bark

(2018) Zoxolo N. Nyaba et al.   MALARIA JOURNAL

Repurposing drugs to target the malaria parasite unfolding protein response

(2018) Yun Chen et al.   Scientific Reports

Function, evolution, and structure of J-domain proteins

(2018) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

(2017) Tawanda Zininga et al.   MOLECULES

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

(2017) Sarah C. Charnaud et al.   PLoS One

The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle

(2017) David W. Cobb et al.   mSphere

Proteomic analysis of exported chaperone/co-chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions

(2017) Qi Zhang et al.   Scientific Reports

Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

(2017) Seong-Hyun Park et al.   Scientific Reports

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion

(2016) Tawanda Zininga et al.   CELL STRESS & CHAPERONES

The Malarial Exported PFA0660w Is an Hsp40 Co-Chaperone of PfHsp70-x

(2016) Michael O. Daniyan et al.   PLoS One

Trafficking of the exported P. falciparum chaperone PfHsp70x

(2016) Manuel Rhiel et al.   Scientific Reports

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein

(2015) Tawanda Zininga et al.   PLoS One

Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity

(2015) Tawanda Zininga et al.   PLoS One

The hsp70 inhibitor VER155008 induces paraptosis requiring de novo protein synthesis in anaplastic thyroid carcinoma cells

(2014) Si Hyoung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity

(2014) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

(2013) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

(2012) Simone Külzer et al.   CELLULAR MICROBIOLOGY

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

(2012) Vasant Muralidharan et al.   Nature Communications

Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

(2011) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock

(2010) Melissa Botha et al.   CELL STRESS & CHAPERONES

Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte

(2010) Simone Külzer et al.   CELLULAR MICROBIOLOGY

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

(2009) Annette N. Chiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells

(2009) Oscar Akide-Ndunge et al.   MALARIA JOURNAL

Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

(2008) Alexander G. Maier et al.   CELL