Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40

(2010) Susanne Wisén et al.   ACS Chemical Biology

Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol

(2010) Evelyn L. Bonifazi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90

(2010) Andrew J. Massey   JOURNAL OF MEDICINAL CHEMISTRY

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

(2010) Christopher G. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

(2009) Annette N. Chiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hsp70-1 from Plasmodium falciparum: Protein stability, domain analysis and chaperone activity

(2009) Gauri Misra et al.   BIOPHYSICAL CHEMISTRY

Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition

(2009) Soh Yamamoto et al.   FEBS LETTERS

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†

(2009) Douglas S. Williamson et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Arylamino and 3-Alkoxy-nor-β-lapachone Derivatives: Synthesis and Cytotoxicity against Cancer Cell Lines

(2009) Eufrânio N. da Silva Júnior et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Hooker’s ‘lapachol peroxide’ revisited

(2009) Eufrânio N. da Silva Júnior et al.   TETRAHEDRON LETTERS

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

(2008) Christine M. Wright et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones

(2008) Eufrânio N. da Silva Júnior et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Chaperones in Pathogen Virulence: Emerging New Targets for Therapy

(2008) Len Neckers et al.   Cell Host & Microbe

The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns

(2008) Eva-Rachele Pesce et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structure-Function Study of a Plasmodium falciparum Hsp70 Using Three Dimensional Modelling and in Vitro Analyses

(2008) Addmore Shonhai et al.   PROTEIN AND PEPTIDE LETTERS

Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase

(2007) Susanne Wisén et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Agrobacterium tumefaciens DnaK: ATPase cycle, oligomeric state and chaperone properties

(2007) Aileen Boshoff et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY