Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Wasp Venom Biochemical Components and Their Potential in Biological Applications and Nanotechnological Interventions

(2021) Aida Abd El-Wahed et al.   Toxins

The antimicrobial peptide MK58911-NH2 acts on planktonic, biofilm and intramacrophage cells of Cryptococcus neoformans

(2021) Junya de Lacorte Singulani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR Acinetobacter baumannii: In silico, in vitro and in vivo Studies

(2021) Afreenish Hassan et al.   International Journal of Nanomedicine

Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields

(2021) Antonio Moretta et al.   Frontiers in Cellular and Infection Microbiology

Involvement of the gabaergic, serotonergic and glucocorticoid mechanism in the anxiolytic-like effect of mastoparan-L

(2020) Osmar N. Silva et al.   NEUROPEPTIDES

Identifying the toxins in hornet (Vespa basalis) venom that induce rat pain responses

(2020) Guokun Zhou et al.   TOXICON

Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide

(2020) Sándor Jenei et al.   Frontiers in Microbiology

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

(2020) Sunithi Gunasekera et al.   Frontiers in Microbiology

Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy

(2020) Ashley L. St. John et al.   npj Vaccines

Synergistic antimicrobial activity of melittin with clindamycin on the expression of encoding exfoliative toxin in Staphylococcus aureus

(2020) Hassan Mahmoudi et al.   TOXICON

Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties

(2020) Osmar N. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sweet as honey, bitter as bile: Mitochondriotoxic peptides and other therapeutic proteins isolated from animal tissues, for dealing with mitochondrial apoptosis

(2020) Francesco Colella et al.   TOXICOLOGY

Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria

(2020) Ningyi Zhu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

(2019) Mohammad Arifuzzaman et al.   Science Advances

New Mastoparan Peptides in the Venom of the Solitary Eumenine Wasp Eumenes micado

(2019) Katsuhiro Konno et al.   Toxins

Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer

(2019) Guangzhi Li et al.   Small

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

(2019) Rogério Coutinho das Neves et al.   Toxins

Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio)

(2019) Mariana C Galeane et al.   Future Microbiology

Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties

(2019) Karen G. N. Oshiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes

(2019) Marcia Perez dos Santos Cabrera et al.   Toxins

Drug repurposing for cancer therapy, easier said than done

(2019) Aurora Gonzalez-Fierro et al.   SEMINARS IN CANCER BIOLOGY

Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

(2018) Xiaoling Chen et al.   International Journal of Biological Sciences

In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates

(2018) Elena Portell-Buj et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera)

(2017) Juliana C. Silva et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action

(2017) Annielle Mendes Brito da Silva et al.   MOLECULAR NEUROBIOLOGY

Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

(2017) Juliana Freire Chagas Vinhote et al.   TOXICON

Efficacy of Mastoparan-AF alone and in combination with clinically used antibiotics on nosocomial multidrug-resistant Acinetobacter baumannii

(2017) Chun-Hsien Lin et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan

(2016) Luz N. Irazazabal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma

(2016) Ashley L. Hilchie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

(2016) Mie Kristensen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MP-V1 from the Venom of Social Wasp Vespula vulgaris Is a de Novo Type of Mastoparan that Displays Superior Antimicrobial Activities

(2016) Yangseon Kim et al.   MOLECULES

Antinociceptive properties of the mastoparan peptide Agelaia-MPI isolated from social wasps

(2016) Jacqueline Gonçalves et al.   TOXICON

Peptide Toxins in Solitary Wasp Venoms

(2016) Katsuhiro Konno et al.   Toxins

Differential Properties of Venom Peptides and Proteins in Solitary vs. Social Hunting Wasps

(2016) Si Lee et al.   Toxins

Identification and biochemical characterization of a new antibacterial and antifungal peptide derived from the insect Sphodromantis viridis

(2015) Hadi Zare-Zardini et al.   BIOCHEMISTRY-MOSCOW

Sequence-activity relationship, and mechanism of action of mastoparan analogues against extended-drug resistant Acinetobacter baumannii

(2015) Xavier Vila-Farrés et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparative bioactivities of mastoparans from social hornets Vespa crabro and Vespa analis

(2015) Kyungjae Andrew Yoon et al.   JOURNAL OF ASIA-PACIFIC ENTOMOLOGY

Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo

(2015) Ricardo A. de Azevedo et al.   PEPTIDES

Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan

(2015) Miguel Moreno et al.   Toxins

Comparative bioactivities of mastoparans from social hornets Vespa crabro and Vespa analis

(2015) Kyungjae Andrew Yoon et al.   JOURNAL OF ASIA-PACIFIC ENTOMOLOGY

The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems

(2014) Alessandra V.R. da Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation

(2014) Kairong Wang et al.   PEPTIDES

Enhancing antimicrobial activity of mastoparan-B by amino acid substitutions

(2013) Mars J. Yang et al.   JOURNAL OF ASIA-PACIFIC ENTOMOLOGY

A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses

(2013) Christopher J. Sample et al.   PEPTIDES

Influence of Short-Chain Cell-Penetrating Peptides on Transport of Doxorubicin Encapsulating Receptor-Targeted Liposomes Across Brain Endothelial Barrier

(2013) Gitanjali Sharma et al.   PHARMACEUTICAL RESEARCH

Antimicrobial peptides from the venom gland of the social wasp Vespa tropica

(2013) Xinwang Yang et al.   TOXICON

Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium

(2013) Victoria Carter et al.   PLoS Pathogens

From antimicrobial to anticancer peptides. A review

(2013) Diana Gaspar et al.   Frontiers in Microbiology

Influence of the Bilayer Composition on the Binding and Membrane Disrupting Effect of Polybia-MP1, an Antimicrobial Mastoparan Peptide with Leukemic T-Lymphocyte Cell Selectivity

(2012) Marcia Perez dos Santos Cabrera et al.   BIOCHEMISTRY

Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections

(2012) K. Leszczynska et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of mastoparan-AF alone and in combination with clinically used antibiotics against multiple-antibiotic-resistant Escherichia coli isolates from animals

(2012) Chun-Hsien Lin et al.   PEPTIDES

Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista

(2012) Kairong Wang et al.   PEPTIDES

Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP-III at the level of endosomal membranes from rat mast cells

(2012) Lucilene Delazari dos Santos et al.   PROTEOMICS

Agelaia MP-I: A peptide isolated from the venom of the social wasp, Agelaia pallipes pallipes, enhances insulin secretion in mice pancreatic islets

(2012) N.B. Baptista-Saidemberg et al.   TOXICON

Purification and structural characterisation of phospholipase A1 (Vespapase, Ves a 1) from Thai banded tiger wasp (Vespa affinis) venom

(2012) Sophida Sukprasert et al.   TOXICON

In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii

(2011) X. Vila-Farres et al.   CLINICAL MICROBIOLOGY AND INFECTION

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan

(2011) Chun-Hsien Lin et al.   PEPTIDES

Analysis of anticancer drugs: A review

(2011) Susanne Nussbaumer et al.   TALANTA

Chemical and biological characterization of four new linear cationic α-helical peptides from the venoms of two solitary eumenine wasps

(2011) Marisa Rangel et al.   TOXICON

Investigating the effect of different positioning of lysine residues along the peptide chain of mastoparans for their secondary structures and biological activities

(2010) Bibiana Monson de Souza et al.   AMINO ACIDS

Comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells

(2010) Satoshi Nakao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice

(2010) Wei Zhang et al.   PEPTIDES

Inflammation and apoptosis induced by mastoparan Polybia-MPII on skeletal muscle

(2010) Thalita Rocha et al.   TOXICON

Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells

(2009) Kai-rong Wang et al.   CANCER LETTERS

Recent Advances in Cancer Therapy: An Overview

(2009) A. Urruticoechea et al.   CURRENT PHARMACEUTICAL DESIGN

Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista

(2009) Bibiana Monson de Souza et al.   PEPTIDES

Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae)

(2009) Ji Hyeong Baek et al.   TOXICON

Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni

(2008) Kazuya Murata et al.   AMINO ACIDS

Selectivity in the mechanism of action of antimicrobial mastoparan peptide Polybia-MP1

(2008) Marcia Perez dos Santos Cabrera et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Mast cell activators: a new class of highly effective vaccine adjuvants

(2008) James B McLachlan et al.   NATURE MEDICINE

New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs

(2008) Václav Čeřovský et al.   PEPTIDES

Antimicrobial peptides from the venoms of Vespa bicolor Fabricius

(2008) Wenhu Chen et al.   PEPTIDES

Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI

(2008) Kai-rong Wang et al.   PEPTIDES

Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus (“spotted treefrog”)

(2008) Mariana S. Castro et al.   PEPTIDES

Mastoparan effects in skeletal muscle damage: An ultrastructural view until now concealed

(2007) Thalita Rocha et al.   MICROSCOPY RESEARCH AND TECHNIQUE