Journal
MOLECULAR NEUROBIOLOGY
Volume 55, Issue 7, Pages 5490-5504Publisher
SPRINGER
DOI: 10.1007/s12035-017-0782-1
Keywords
Mastoparan; Glioblastoma; Cationic peptide; Necrosis; Phosphatidylserine
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp) [2012/02065-0, 2016/13368-4, 2012/50336-2]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [477780/2010-5]
- Capes
- CNPq [142066/2014-1]
- Fapesp [2009/53840-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/53840-0] Funding Source: FAPESP
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Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of its complexity and heterogeneity, this tumor has become resistant to conventional therapies and the available treatment produces multiple side effects. Here, using multiple experimental approaches, we demonstrate that three mastoparan peptides-Polybia-MP1, Mastoparan X, and HR1-from solitary wasp venom exhibit potent anticancer activity toward human glioblastoma multiforme cells. Importantly, the antiglioblastoma action of mastoparan peptides occurs by membranolytic activity, leading to necrosis. Our data also suggest a direct relation between mastoparan membranolytic potency and the presence of negatively charged phospholipids like phosphatidylserine. Collectively, these data may warrant additional studies for mastoparan peptides as new agents for the treatment of glioblastoma multiforme brain tumor.
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