Article
Pharmacology & Pharmacy
Popat Kumbhar, Kapil Kole, Tejashree Yadav, Ashwini Bhavar, Pramod Waghmare, Rajdeep Bhokare, Arehalli Manjappa, Niraj Kumar Jha, Dinesh Kumar Chellappan, Sunita Shinde, Sachin Kumar Singh, Kamal Dua, Ahmad Salawi, John Disouza, Vandana Patravale
Summary: Skin cancer is a common form of cancer, and its treatment with chemotherapy has limitations. Drug repurposing, using previously approved drugs for the treatment of other diseases like cancer, offers a promising approach with advantages in time and cost.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xin Wang, Han Wang, Guosheng Yin, Yan Dora Zhang
Summary: Through a network-based drug repurposing approach, effective drug candidates for treating COVID-19 patients in different clinical stages are identified by integrating publicly available clinical transcriptome and experimental data. We identified 51 drugs that regulate proteins interacted with SARS-CoV-2 protein through biological pathways against COVID-19, some of which have been experimented in clinical trials. Our study has provided comprehensive understanding of potential drug mechanisms and identified effective drug candidates against COVID-19 for patients in different clinical stages.
Article
Biochemistry & Molecular Biology
Faheem Ahmed, Young Jin Yang, Anupama Samantasinghar, Young Woo Kim, Jeong Beom Ko, Kyung Hyun Choi
Summary: This study presents an integrative drug repurposing framework based on a systems biology-enabled network medicine platform to quickly identify suitable repurposable drugs and drug combinations that target HPV-associated cervical cancer (CC).
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Laura Chaffey, Annabell Roberti, David R. Greaves
Summary: Drug repurposing is a promising approach in drug discovery for cardiovascular disease. Chronic inflammation plays a significant role in cardiovascular pathology, and targeting inflammation is a potential therapeutic strategy. However, challenges remain due to off-target effects and long-term conditions. Assessing repurposed anti-inflammatory drugs in cardiovascular clinical trials has shown mixed successes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
Ningna Weng, Zhe Zhang, Yunhan Tan, Xiaoyue Zhang, Xiawei Wei, Qing Zhu
Summary: This article summarizes the background, aim, and key scientific concepts of repurposing antifungal drugs for cancer therapy, and discusses the challenges and perspectives for their future development and clinical applications.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Rafaela Rodrigues, Diana Duarte, Nuno Vale
Summary: Cancer is a leading cause of death worldwide, with breast cancer being the most prevalent type in women. Drug resistance poses a major challenge in breast cancer treatment, leading to high mortality rates. Repurposing drugs and conducting further research and clinical trials are important for improving the effectiveness and personalization of breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Rita Rebelo, Barbara Polonia, Lucio Lara Santos, M. Helena Vasconcelos, Cristina P. R. Xavier
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly tumor with limited diagnostic and treatment options. Drug repurposing may offer a time-efficient and cost-effective approach for PDAC treatment. Multiple drugs have been studied for repurposing in PDAC treatment, but further research is needed to support their clinical applications.
Review
Computer Science, Interdisciplinary Applications
Faheem Ahmed, Anupama Samantasinghar, Afaque Manzoor Soomro, Sejong Kim, Kyung Hyun Choi
Summary: Cancer is the second leading cause of death globally, with a low success rate for new drug development. Drug repurposing offers a promising alternative approach for understanding cancer biology and developing effective treatments. This review analyzes computational approaches for cancer biology, including systems biology and pathway analysis, and examines their use in drug repurposing. Case studies are presented, along with limitations and recommendations for future research.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Biology
Siddhant Doshi, Sundeep Prabhakar Chepuri
Summary: Drug repurposing is a method of finding new medical indications for approved drugs. This study introduces a graph neural network drug repurposing model called GDRnet, which efficiently screens a database of approved drugs and predicts potential treatments for novel diseases.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Deisy Morselli Gysi, Italo do Valle, Marinka Zitnik, Asher Ameli, Xiao Gan, Onur Varol, Susan Dina Ghiassian, J. J. Patten, Robert A. Davey, Joseph Loscalzo, Albert-Laszlo Barabasi
Summary: The study utilized multiple algorithms to rank a large number of drugs, finding that combining the consensus of various predictive methods significantly improves the success rate of drug screening and proposes new medications for treating COVID-19. Furthermore, it was discovered that the majority of drugs successfully reducing viral infection do not bind to the target proteins of SARS-CoV-2, suggesting a network-based mechanism rather than docking strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Medicinal
Alexander Vaiserman, Alexander Koliada, Oleh Lushchak, Manuel J. Castillo
Summary: Life expectancy has been steadily increasing in developed countries, but healthspan extension has not kept pace. Aging is the main risk factor for age-associated pathological conditions. Repurposing existing medications to target the aging process for human healthspan extension faces challenges.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Biochemical Research Methods
Nicoleta Siminea, Victor Popescu, Jose Angel Sanchez Martin, Daniela Florea, Georgiana Gavril, Ana-Maria Gheorghe, Corina Itcus, Krishna Kanhaiya, Octavian Pacioglu, Laura Lona Popa, Romica Trandafir, Maria Iris Tusa, Manuela Sidoroff, Mihaela Paun, Eugen Czeizler, Andrei Paun, Ion Petre
Summary: By analyzing control strategies for host factors, we constructed a PPI network and identified drug targets and combinations that can effectively control these factors. We validated our findings and highlighted their significance in COVID-19 and other diseases.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Oncology
Shraddha M. Dalwadi, Andrew Hunt, Mark D. Bonnen, Yohannes T. Ghebre
Summary: This review discusses the strategy of using computational approaches to repurpose existing drugs for new therapeutic use in oncology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Giovanni Oliveros, Charles H. Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E. Figueiredo-Pereira, Peter A. Serrano
Summary: Using multiscale predictive modelling, researchers have identified the multi-target asthma drug ibudilast as a potential repurposed treatment for Alzheimer's disease. Experimental results in a transgenic rat model showed that ibudilast reduced inflammation, plaque and tangle pathology, as well as cognitive deficits. These findings suggest that ibudilast could be an effective treatment option for Alzheimer's disease by targeting multiple pathways.
Review
Oncology
Thomas Efferth, Franz Oesch
Summary: Drug repurposing is the concept of using old drugs for new treatments, and plant alkaloids have potential for repositioning in cancer therapy. They can affect cancer cell growth through various mechanisms, including inhibiting tumor growth, inducing apoptosis, and inhibiting angiogenesis. However, some plant alkaloids also exhibit toxicities that need to be carefully considered.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Medical Informatics
Alfonso Duenas-Gonzalez, Aurora Gonzalez-Fierro
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2020)
Article
Oncology
Mandy Juarez, Alejandro Schcolnik-Cabrera, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Jose Diaz-Chavez, Alfonso Duenas-Gonzalez
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Alejandro Schcolnik-Cabrera, Daniel Juarez-Lopez, Alfonso Duenas-Gonzalez
Summary: Drug repurposing offers a faster and more cost-effective approach to developing treatments for common diseases compared to traditional methods. Collaboration between government, society, and private investors is crucial to ensure the development of repurposed drugs that are affordable, effective, and safe.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Adriana Romo-Perez, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Lucia Taja-Chayeb, Aurora Gonzalez-Fierro, Elisa Garcia-Martinez, Jose Correa-Basurto, Alfonso Duenas-Gonzalez
Summary: The high cost of cancer drugs is a limiting factor in reducing global cancer mortality. Repurposing existing, commercially available, and inexpensive drugs may help lower costs. This study reviews the concept of the malignant metabolic phenotype and proposes a combination therapy that simultaneously targets key metabolic processes altered in cancer.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Oncology
Adriana Romo-Perez, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Lucia Taja-Chayeb, Aurora Gonzalez-Fierro, Consuelo Diaz-Romero, Horacio Noe Lopez-Basave, Alfonso Duenas-Gonzalez
Summary: Gastric cancer causes significant metabolic alterations including high rates of glycolysis, glutaminolysis, de novo fatty acid synthesis, and cholesterol synthesis. Blocking these pathways simultaneously may reduce metabolic flexibility and enhance treatment efficacy.
CURRENT CANCER DRUG TARGETS
(2022)
Review
Gastroenterology & Hepatology
L. Taja-Chayeb, S. Vidal-Millan, C. Trejo-Becerril, E. Perez-Cardenas, A. Chavez-Blanco, G. Dominguez-Gomez, A. Gonzalez-Fierro, A. Romo-Perez, A. Duenas-Gonzalez
Summary: It is estimated that up to 10% of gastric carcinomas show familial aggregation, while around 1-3% are genuinely hereditary. Hereditary diffuse gastric cancer (HDGC) is a rare malignancy characterized by the inheritance of pathological variants of the CDH1 and CTNNA1 genes. The disease is difficult to diagnose and manage, highlighting the importance of correctly identifying and offering adequate management to patients and their families. A critical point is identifying mutations in HDGC families to assess the risk for unaffected relatives. Evaluation: 8 points.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Review
Pharmacology & Pharmacy
Aurora Gonzalez-Fierro, Adriana Romo-Perez, Alma Chavez-Blanco, Guadalupe Dominguez-Gomez, Alfonso Duenas-Gonzalez
Summary: Therapeutic repurposing is an alternative to traditional drug discovery and development model, aiming to develop lower-cost drugs faster, safer, and cheaper. Only three drugs have been repurposed for cancer treatment, with different histories regarding price and affordability. Economic constraints and prescription biases are barriers to be overcome. The affordability of cancer drugs varies from country to country, and current measures to reduce prices have failed. Critical analysis of the current drug development model and implementation of new models are needed to genuinely benefit society.
CLINICAL DRUG INVESTIGATION
(2023)
Review
Oncology
Benjamin Robles-Banuelos, Adriana Romo-Perez, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Aurora Gonzalez-Fierro, Alfonso Duenas-Gonzalez
Summary: This study examined the correlation between drug concentrations and clinical relevance in widely used cancer drugs, and found that AUC is more closely related to IC50 than C-max. The suggestion is made to use AUC as the translated drug concentration for in vitro testing in drug repurposing.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)