Review
Horticulture
Paloma Rodriguez-Lopez, Ascension Rueda-Robles, Isabel Borras-Linares, Rosa Maria Quirantes-Pine, Tatiana Emanuelli, Antonio Segura-Carretero, Jesus Lozano-Sanchez
Summary: This systematic review focuses on the phenolic profiles of grape, juice, and wine, as well as the potential benefits of their consumption on the human microbiota. It highlights the possibility of exploring a new research area based on the synergy between polyphenol consumption and microbiota, and emphasizes the urgent need for strategies to improve the bioavailability of these compounds.
Article
Biochemistry & Molecular Biology
Xincheng Wu, Xiaojun Huang, Wanning Ma, Mingzhi Li, Jiajia Wen, Chunhua Chen, Liandi Liu, Shaoping Nie
Summary: This study compared the intestinal immunomodulatory mechanisms of nine representative bioactive polysaccharides. The results revealed that these polysaccharides promote intestinal immunity through different ways, such as alleviating immune suppression in intestinal mucosal T cells, improving the intestinal microenvironment, promoting the colonization of beneficial bacteria, inhibiting the colonization of harmful bacteria, and alleviating the accumulation of certain metabolites in the large intestine. These findings provide a guideline for the development of superior intestinal immunomodulatory polysaccharides.
Article
Food Science & Technology
Benjamin Vazquez-Rodriguez, Liliana Santos-Zea, Erick Heredia-Olea, Laura Acevedo-Pacheco, Arlette Santacruz, Janet A. Gutierrez-Uribe, Lucia Elizabeth Cruz-Suarez
Summary: The hydroethanolic extract of Silvetia compresssa, rich in phlorotannins and polysaccharides, showed potential to promote the growth of probiotic bacteria and synthesis of short-chain fatty acids in early colon fermentation, resulting in an improved human gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Daiane Santos, Bruna Krieger Vargas, Elionio Galvao Frota, Barbara Biduski, Samuel Teixeira Lopes, Julia Pedo Gutkoski, Lara Franco dos Santos, Giseli Aparecida Ritterbusch, Romulo Pillon Barcelos, Sabrina Somacal, Tatiana Emanuelli, Telma Elita Bertolin
Summary: This study assessed the potential of yerba-mate extract to modulate the intestinal microbiota in rats. The results showed that yerba-mate extract possesses significant antioxidant activity and can effectively modulate the intestinal microbiota. These findings support the potential use of yerba-mate as an alternative for controlling and preventing diseases associated with intestinal dysbiosis.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Microbiology
Kitty Reemst, Sebastian Tims, Kit-Yi Yam, Mona Mischke, Jan Knol, Stanley Brul, Lidewij Schipper, Aniko Korosi
Summary: Early-life stress and dietary polyunsaturated fatty acids have an impact on the gut microbiota, which is related to cognitive, metabolic, and fatty acid profiles.
Review
Biology
Yuanyuan Jin, Ling Chen, Yufen Yu, Muhammad Hussain, Hao Zhong
Summary: Fruit intake plays a crucial role in regulating the gut microbiota and has potential benefits for host health. Fruits contain bioactive compounds that can interact with microorganisms and help balance the gut microbiota, thus contributing to disease prevention and treatment.
Review
Biochemistry & Molecular Biology
Yoko Matsumura, Masahiro Kitabatake, Shin-ichi Kayano, Toshihiro Ito
Summary: Oxidative stress can cause diseases, but antioxidants in foods can prevent diseases and delay aging. Phenolic compounds, such as flavonoids, are present in plants and contribute to the bitterness and color of foods. Dietary phenolic compounds exhibit antioxidant activity and can prevent cell aging and diseases. The structures of these compounds can be changed by intestinal bacteria metabolism, and the resulting metabolites exert effects in vivo.
Article
Chemistry, Applied
Ali Sabra, Thomas Netticadan, Champa Wijekoon
Summary: Grapes are a rich source of bioactive compounds with antioxidant, anti-inflammatory, and anti-carcinogenic activities. These compounds have wide applications in food and nutraceutical industries, and are linked to reducing the incidence of cardiovascular disease and hypertension.
Article
Chemistry, Applied
Daoyan Wu, Liwei Chen, Jean Teh, Edric Sim, Joergen Schlundt, Patricia L. Conway
Summary: This study investigated the anti-inflammatory effects of different sourced honeys and their impact on elderly gut microbiota. The results showed that these honeys suppressed inflammation, modulated gut microbiota, and provided health benefits.
Article
Food Science & Technology
B. I. Martinez-Mendoza, A. Peredo-Lovillo, H. E. Romero-Luna, M. Jimenez-Fernandez
Summary: This study aimed to improve the health-promoting properties of soursop and passion fruit pulps through controlled yeast fermentation. Fermented pulps showed increased viable cell counts and antioxidant activities. Various compounds were identified in the fermented pulps, demonstrating the potential for generating new functional foods.
Article
Microbiology
Isabelle Bourdeau-Julien, Sophie Castonguay-Paradis, Gabrielle Rochefort, Julie Perron, Benoit Lamarche, Nicolas Flamand, Vincenzo Di Marzo, Alain Veilleux, Frederic Raymond
Summary: This study aimed to investigate the effects of a lead-in diet on the response to a short-term dietary intervention. The results showed that dietary changes had an immediate and reversible modulation on gut microbiota composition, endocannabinoidome mediators, short-chain fatty acids, and branched-chain fatty acids. The response of gut microbiota composition was more influenced by the lead-in diet, while the endocannabinoidome response was not affected. Higher initial microbiome diversity favored the stability of gut microbiota in response to dietary changes.
Article
Chemistry, Multidisciplinary
Nuno Rodrigues, Catarina Oliveira, Susana Casal, Jose Alberto Pereira, Elsa Ramalhosa
Summary: This study produced different table olive flours with distinct properties and high amounts of health-promoting compounds from natural table olives at different maturation stages. The flours were characterized by their physical and nutritional properties, as well as their antioxidant activity. The results showed that these flours contained a rich amount of health-promoting compounds.
APPLIED SCIENCES-BASEL
(2022)
Article
Nutrition & Dietetics
Erika Kwek, Hanyue Zhu, Huafang Ding, Zouyan He, Wangjun Hao, Jianhui Liu, Ka Ying Ma, Zhen-Yu Chen
Summary: Peony seed oil (PSO) is effective in reducing plasma cholesterol and hepatic lipids, and favorably modulating gut microbiota associated with cholesterol metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Chemistry, Physical
Renata Vardanega, Francisca Salinas Fuentes, Jenifer Palma, Waldo Bugueno-Munoz, Pedro Cerezal-Mezquita, Mari Carmen Ruiz-Dominguez
Summary: The development of food waste biorefineries based on clean technologies aims to reduce food waste and its impact on climate change. This study developed a sequential extraction process using supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE) to recover valuable compounds from granadilla seeds. The optimized SFE conditions yielded a PUFA-rich oil, while PLE at 70°C and 10 MPa with 75% EtOH was more efficient in extracting phenolic compounds from the defatted seeds compared to ultrasound-assisted extraction (UAE).
JOURNAL OF SUPERCRITICAL FLUIDS
(2023)
Review
Chemistry, Medicinal
Bozena McCarthy, Graham O'Neill, Nissreen Abu-Ghannam
Summary: Sleep deficiency is a global epidemic associated with serious health problems and financial burdens. It is closely connected to mental health, worsening its negative impact on overall well-being. Conventional treatments have drawbacks due to undesirable side-effects, making the exploration of other remedies valuable. This review focuses on microalgae bioactives as a sustainable source of beneficial phytochemicals that can positively contribute to mood and sleep disorders, providing a useful reference for further exploration.
Review
Microbiology
Mirco Vacca, Annalisa Porrelli, Francesco Maria Calabrese, Tamara Lippolis, Ilaria Iacobellis, Giuseppe Celano, Daniela Pinto, Francesco Russo, Gianluigi Giannelli, Maria De Angelis
Summary: Celiac disease is an autoimmune disorder triggered by ingesting gluten and is diagnosed through invasive methods. CD and GFD both impact the gut microbiota, resulting in changes to specific metabolite production. The application of metabolomics in CD research is still relatively unexplored.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giusy Rita Caponio, Miriam Cofano, Tamara Lippolis, Isabella Gigante, Valentina De Nunzio, Graziana Difonzo, Mirella Noviello, Luigi Tarricone, Giuseppe Gambacorta, Gianluigi Giannelli, Maria De Angelis, Maria Notarnicola
Summary: This study investigates the effects of grape pomace extract on colon cancer cells, showing its anti-proliferative and apoptosis-inducing effects. Phenolic compounds were found to be the main active ingredients, and the extract digested with simulated gastrointestinal digestion could potentially be used as a dietary ingredient with health benefits for colon cancer cell proliferation.
Article
Biochemistry & Molecular Biology
Maria Notarnicola, Valentina De Nunzio, Tamara Lippolis, Valeria Tutino, Anna Maria Cisternino, Palma Aurelia Iacovazzi, Rosa Anna Milella, Marica Gasparro, Roberto Negro, Maurizio Polignano, Maria Gabriella Caruso
Summary: This clinical trial investigated the effects of fresh table grape intake on the serum Omega-3 index. The results showed that grape intake increased oleic acid content, improved the Omega-3 index, increased adiponectin levels, and reduced FGF21 levels, leading to beneficial effects on liver function.
Review
Biochemistry & Molecular Biology
Tamara Lippolis, Miriam Cofano, Giusy Rita Caponio, Valentina De Nunzio, Maria Notarnicola
Summary: It is commonly acknowledged that polyphenols derived from diet have several potential benefits for human health. Polyphenols have various chemical structures, with flavonoids, phenolic acids, and stilbenes being the most representative types. The beneficial effects of polyphenols are closely linked to their bioavailability and bioaccessibility, as many of them are quickly metabolized after being consumed. Polyphenols, which protect the gastrointestinal tract, promote the maintenance of a healthy intestinal microbiota, thereby guarding against gastric and colon cancers. Therefore, it seems that the beneficial effects of dietary polyphenol supplementation are mediated by the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Maria Calasso, Marinella Marzano, Giusy Rita Caponio, Giuseppe Celano, Bruno Fosso, Francesco Maria Calabrese, Domenico De Palma, Mirco Vacca, Elisabetta Notario, Graziano Pesole, Maria De Angelis, Francesca De Leo
Summary: To extend the shelf-life of bakery products, a type-III sourdough combined with a mixture of probiotics was used, which resulted in improved physicochemical and microbiological attributes. The addition of bioprotective-cultures and the sourdough had positive effects on microbial and metabolite improvements in the products, leading to a longer shelf-life. These findings suggest a potential alternative to chemical preservatives for extending the shelf-life of processed foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Green & Sustainable Science & Technology
Giusy Rita Caponio, Fabio Minervini, Grazia Tamma, Giuseppe Gambacorta, Maria De Angelis
Summary: Grapes, especially Vitis vinifera L., are widely cultivated and winemaking produces a large amount of waste. These residues are causing environmental and economic sustainability issues. To combat this, researchers are exploring ways to create high-value products from these waste materials. Grape pomace, a byproduct of winemaking, contains compounds like polyphenols, phenolic acids, resveratrol, and fiber that have antioxidant properties. Traditional uses of grape pomace include producing distillates and extracting tartaric acid and coloring substances, but newer applications include extracting antioxidants, using it as fermentation substrates and biomass for energy production, and extracting fiber for high-value bioactive product development. This article discusses the involvement of bioactive molecules from grape pomace in human biological functions and their applications in the agri-food sector.
Article
Medicine, General & Internal
Valentina De Nunzio, Rossella Donghia, Pasqua L. Pesole, Sergio Coletta, Nicola Calo, Maria Notarnicola
Summary: The location of the tumor in colorectal cancer is crucial in determining disease progression, with right-sided and left-sided colon tumors showing distinct clinical and molecular characteristics. Dysregulation of proinflammatory cytokines (TGF-β, TNF-α) and PPAR-γ, as well as changes in miRNA expression, are key pathways involved in the development of this cancer. Analysis of circulating levels of TGF-β, TNF-α, PPAR-γ, and specific miRNAs in the serum can help identify specific characteristics of colorectal cancer patients, aiding in personalized treatment selection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Robertina Giacconi, Rossella Donghia, Graziana Arborea, Maria Teresa Savino, Mauro Provinciali, Fabrizia Lattanzio, Giusy Rita Caponio, Sergio Coletta, Antonia Bianco, Maria Notarnicola, Caterina Bonfiglio, Giuseppe Passarino, Patrizia DAquila, Dina Bellizzi, Pasqua Letizia Pesole
Summary: This study found that patients with colorectal cancer have higher levels of bacterial DNA in their plasma compared to healthy individuals, and this is associated with the size of the tumor mass.
Article
Nutrition & Dietetics
Francesco Maria Calabrese, Vittoria Disciglio, Isabella Franco, Paolo Sorino, Caterina Bonfiglio, Antonella Bianco, Angelo Campanella, Tamara Lippolis, Pasqua Letizia Pesole, Maurizio Polignano, Mirco Vacca, Giusy Rita Caponio, Gianluigi Giannelli, Maria De Angelis, Alberto Ruben Osella
Summary: This study investigates the impact of different lifestyle interventions on the gut microbiota composition in NAFLD patients and demonstrates the synergistic effect of lifestyle interventions (diet and/or physical activity programs) on the gut microbiota composition in NAFLD patients.
Article
Biochemistry & Molecular Biology
Antonella Orlando, Guglielmina Chimienti, Maria Notarnicola, Francesco Russo
Summary: This study evaluated the effects of a neuroprotective diet on the levels of neurotransmitters and neurotrophins in the gut and brain of rats with irritable bowel syndrome. The diet was found to improve the dysregulation of the 5-HT and BDNF systems, reducing intestinal 5-HT levels and increasing brain BDNF levels. This suggests that the diet may have therapeutic potential for managing intestinal dysfunctions associated with irritable bowel syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
