Article
Chemistry, Multidisciplinary
Abderrahmene Bouaouich, Faiza Bouguerche, Houda Mahiaoui, Gregorio Peron, Hamdi Bendif
Summary: This study characterized fatty acids and secondary metabolites in seeds of three cultivars of Opuntia ficus-indica L. harvested from Algeria. The antioxidant activity of seed extracts was assessed and results showed varying total phenolic content among the cultivars. HPLC and GC analyses revealed the presence of phenolic compounds and essential fatty acids in the seed extracts and oil, respectively. The results highlight the potential of O. ficus-indica seeds as valuable sources of table oil, cooking oil, and antioxidants.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Nguyen Thi Hoa, Do Thi Ngoc Hang, Do Phu Hieu, Huynh Van Truong, Loc Phuoc Hoang, Adam Mechler, Quan V. Vo
Summary: Sulfuretin demonstrates superior hydroperoxyl radical scavenging activity compared to traditional antioxidants like resveratrol, ascorbic acid, and Trolox. Its effectiveness in neutral and non-polar environments indicates its potential as a radical scavenger in physiological conditions.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ana L. Becerril-Sanchez, Baciliza Quintero-Salazar, Octavio Dublan-Garcia, Hector B. Escalona-Buendia
Summary: Honey has been used since ancient times for its sensory, nutritional, and therapeutic properties, which are related to its physical and chemical composition. Phenolic compounds play a significant role in honey, influencing its antioxidant activity, botanical-geographical origin, and sensory characteristics. Researchers are increasingly interested in the study of phenolic compounds and their impact on honey's biological and functional activity.
Article
Biochemistry & Molecular Biology
Marko R. Antonijevic, Edina H. Avdovic, Dusica M. Simijonovic, Ziko B. Milanovic, Ana D. Amic, Zoran S. Markovic
Summary: This paper investigated the antioxidative properties and radical scavenging abilities of five different coumarin derivatives. The results showed that these compounds have good antioxidative potential and radical scavenging abilities, and they meet the criteria of drug-likeness tests. In addition, three additional mechanisms of radical scavenging activity were discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Daniela Horvat, Marija Viljevac Vuletic, Luka Andric, Renata Balicevic, Marija Kovacevic Babic, Marijana Tucak
Summary: Alfalfa is an important forage species that has gained attention for its bioactive phenolic content. This study evaluated the forage quality, phenolic profiles, and antioxidant potential of seventeen cultivars/populations of alfalfa. Significant differences were observed among the studied alfalfa in all analyzed traits, with phenolic data being more discriminative than forage quality. Several cultivars/populations showed interesting phenolic health-promoting characteristics.
Article
Polymer Science
Quan V Vo, Le Thi Ngoc Van, Nguyen Thi Hoa, Adam Mechler
Summary: Iminostilbene is commonly used as a polymerization inhibitor to halt radical polymerization reactions and is known for its antioxidant properties. Computational methods were used to evaluate its antiradical activity against various radicals, with results showing effective scavenging activity in gas phase and in a benzene environment.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Horticulture
Jameel Mohammed Al-Khayri, Poornananda Madhava Naik
Summary: Plant hormones play a crucial role in the growth and induction of bioactive compounds in plant suspension cultures. This study found that the optimum biomass accumulation in date palm cell suspension cultures was achieved with the addition of 1 mg/L 2,4-D + 5 mg/L 2iP. Additionally, cultures containing 5 mg/L 2,4-D and 2.5 mg/L 2iP showed the highest accumulation of phenolics, flavonoids, and radical scavenging activity, as well as a significantly higher content of caffeic acid.
Article
Biochemistry & Molecular Biology
Guozhi Zhu, Dawei Ye, Xiaotian Chen, Yuchao Wu, Zongmei Yang, Yuliang Mai, Bing Liao, Jiazhi Chen
Summary: Lignin can be valorized into biobased polyphenols antioxidants, which have attracted increasing interest in the industry due to their phenolic structures. In this study, lignin-derived polyphenols with enhanced antioxidant activities were prepared from different technical lignins via chemical demethylation. The structural evolution of lignin showed that the phenolic-OH content increased while the molecular weight slightly decreased after the demethylation process. The activities of the prepared polyphenols were found to be related to the phenolic-OH contents and molecular weights.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Umair Shabbir, Akanksha Tyagi, Hun Ju Ham, Fazle Elahi, Deog-Hwan Oh
Summary: This study found that black soybean fermented with P. acidilactici has the ability to inhibit inflammation and cholinesterase enzymes. Increased antioxidant capacity, anthocyanins, phenolics, flavonoids, and GABA content were observed in the fermented samples. A total of 38 bioactive components were identified using the UHPLC-ESI-QTOF-MS/MS technique. These findings suggest that fermentation of black soybean with P. acidilactici is a promising approach for the development of functional foods to inhibit/prevent AD and other neurodegenerative diseases.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Alexandr Mikyska, Martin Dusek, Martin Slaby
Summary: Decoction mashing has a significant effect on polyphenols in beer, increasing the content of flavonoid compounds and potentially benefiting the sensory stability of beer and the health of beer consumers.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Nguyen Thi Hoa, Mai Van Bay, Adam Mechler, Quan V. Vo
Summary: Mexidol is a registered therapeutic agent for the treatment of anxiety disorders and also acts as an antioxidant. It exhibits moderate radical scavenging activity against hydroperoxyl radicals and can chelate with Cu(II) to suppress the rate of oxidation reactions, primarily functioning as an OIL-1 inhibitor.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ziko Milanovic, Dusan Dimic, Milan Zizic, Dejan Milenkovic, Zoran Markovic, Edina Avdovic
Summary: Coumarin derivatives have beneficial biological activities, and two newly synthesized 4,7-dihydroxycoumarin derivatives were found to exhibit antiradical capacity through mechanisms such as HAT and SPLET. EPR results showed a significant reduction in the amount of HO center dot by both compounds, with A-4OH demonstrating better antioxidant capacity than A-3OH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ylenia Spissu, Katarzyna Angelika Gil, Antonio Dore, Giulia Sanna, Giuseppe Palmieri, Andrea Sanna, Maurizio Cossu, Feten Belhadj, Boutheina Gharbi, Maria Barbara Pinna, Antonio Barberis, Carlo Ignazio Giovanni Tuberoso, Guy D'hallewin
Summary: This study examined the phenolic composition of Syrah and Chardonnay grape pomaces to evaluate their antioxidant and prooxidant properties, as well as their impact on melanoma cancer cells. The polyphenols were extracted using a green hydroalcoholic solvent and underwent thorough chemical and electrochemical characterization. The research utilized cyclic voltammetry and other tests to assess the pomace's antioxidant and prooxidant capacity, and conducted biological experiments on melanoma cells. The results showed that the pomace exhibited a moderate antioxidant capacity and induced prooxidant activity when combined with non-toxic doses of H2O2, likely due to the presence of copper. The study highlights the potential of winemaking by-products for cosmeceutical production and combined therapies with approved anticancer drugs.
Article
Food Science & Technology
Remigiusz Oledzki, Krzysztof Lutoslawski, Paulina Nowicka, Aneta Wojdylo, Joanna Harasym
Summary: Non-commercial hybrid grape cultivars, especially the skins, have high antioxidant activity and polyphenolic compounds, making them valuable for human health.
Article
Biochemistry & Molecular Biology
Ivana Buljeta, Anita Pichler, Josip Simunovic, Mirela Kopjar
Summary: The study found that increasing the amount of citrus fiber decreased the concentration of polyphenols and antioxidant activity in the complexes, which degraded during storage. This suggests that citrus fiber could be used as a carrier for blackberry juice polyphenols to enhance the antioxidant potential of food products.
Article
Food Science & Technology
Giuseppe Natrella, Mirella Noviello, Antonio Trani, Michele Faccia, Giuseppe Gambacorta
Summary: An experiment was conducted to investigate the impact of ultrasound treatment on the volatile profile of three red grape cultivars during vinification. A robust SPME-GC-MS method was developed to optimize the recovery of volatile organic compounds (VOCs). The results showed that the effect of ultrasound treatment on the VOC profile was dependent on the grape cultivar, with Aglianico being the most affected and Primitivo showing no significant changes.
Article
Nutrition & Dietetics
Francesco Maria Calabrese, Giuseppe Celano, Caterina Bonfiglio, Angelo Campanella, Isabella Franco, Alessandro Annunziato, Gianluigi Giannelli, Alberto Ruben Osella, Maria De Angelis
Summary: Calorie-restrictive dietary interventions and physical activity regimens can reduce the progression of NAFLD, and there is a close relationship between liver function and gut microbiota.
Review
Green & Sustainable Science & Technology
Giusy Rita Caponio, Fabio Minervini, Grazia Tamma, Giuseppe Gambacorta, Maria De Angelis
Summary: Grapes, especially Vitis vinifera L., are widely cultivated and winemaking produces a large amount of waste. These residues are causing environmental and economic sustainability issues. To combat this, researchers are exploring ways to create high-value products from these waste materials. Grape pomace, a byproduct of winemaking, contains compounds like polyphenols, phenolic acids, resveratrol, and fiber that have antioxidant properties. Traditional uses of grape pomace include producing distillates and extracting tartaric acid and coloring substances, but newer applications include extracting antioxidants, using it as fermentation substrates and biomass for energy production, and extracting fiber for high-value bioactive product development. This article discusses the involvement of bioactive molecules from grape pomace in human biological functions and their applications in the agri-food sector.
Article
Biochemistry & Molecular Biology
Mirco Vacca, Daniela Pinto, Alessandro Annunziato, Arianna Ressa, Maria Calasso, Erica Pontonio, Giuseppe Celano, Maria De Angelis
Summary: This study aimed to investigate the characteristics of a laboratory-made gluten-free bread supplemented with powdered extract from artichoke leaves. The results showed that the bread with artichoke extract had a lower glycemic index and higher antioxidant properties. Fecal fermentation experiments revealed that the bread with artichoke extract had higher levels of volatile organic compounds and could reduce the expression of inflammatory cytokines in cells. Overall, this preliminary study suggests that combining artichoke extract with sourdough technology could enhance the nutritional and healthy features of gluten-free bread.
Review
Biochemistry & Molecular Biology
Graziana Difonzo, Claudia Antonino, Giacomo Squeo, Francesco Caponio, Michele Faccia
Summary: Agri-food companies generate plant by-products with functional bioactive compounds. This review highlights the applications of these by-products in cheesemaking, focusing on their bioactivities and functional properties. Polyphenol-rich by-products enhance antioxidant and antimicrobial activities in cheeses, improving their shelf life. However, the impact on color and sensory properties of enriched cheeses varies depending on the selected by-products and extraction techniques. Additionally, functional compounds in cheeses act as prebiotics and enhance human health. Overall, utilizing agri-food by-products in cheese formulation benefits agri-food chain sustainability and consumer health.
Article
Food Science & Technology
Giuseppe Natrella, Giuseppe Gambacorta, Michele Faccia
Summary: This study demonstrates that combining a commercial bio-protective starter and modified atmosphere packaging (MAP) can extend the shelf-life of burrata cheese manufactured in Italy.
Article
Food Science & Technology
Roberta Miolla, Giovanni Ottomano Palmisano, Rocco Roma, Francesco Caponio, Graziana Difonzo, Annalisa De Boni
Summary: In recent years, consumers have shown interest in functional foods while also becoming more aware of the issue of waste in the agri-food supply chains. This research focuses on the potential reuse of by-products from wine processing in food production. The study investigates consumer acceptance of bread enriched with wine by-products and finds that acceptance is not influenced by socio-economic factors but is related to consumer sensitivity. Targeted strategies should be developed to educate consumers about the benefits of consuming bread enriched with oenological by-products.
Article
Infectious Diseases
Lidia Dalfino, Monica Stufano, Davide Fiore Bavaro, Lucia Diella, Alessandra Belati, Stefania Stolfa, Federica Romanelli, Luigi Ronga, Rosa Di Mussi, Francesco Murgolo, Daniela Loconsole, Maria Chironna, Adriana Mosca, Maria Teresa Montagna, Annalisa Saracino, Salvatore Grasso
Summary: There is a lack of evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB). This study evaluated the effectiveness of first-line therapy with old and novel CRAB active antibiotics in monomicrobial VAP caused by CRAB. The results showed that timely active therapy improves infection outcomes, and cefiderocol holds promise as a first-line therapeutic option.
Article
Public, Environmental & Occupational Health
Arnold Knijn, Valeria Michelacci, Federica Gigliucci, Rosangela Tozzoli, Paola Chiani, Fabio Minelli, Gaia Scavia, Eleonora Ventola, Stefano Morabito
Summary: Pathogen genomics is revolutionizing infectious disease surveillance and enhancing our understanding of evolution and spread of disease-causing agents, host-pathogen interactions, and antibiotic resistance. This field plays a critical role in the development of One Health Surveillance, where public health experts from various disciplines integrate pathogen research methods for monitoring, management, and prevention of outbreaks. The ARIES Genomics project aims to provide an Information System for collecting genomic and epidemiological data to enable genomics-based surveillance of infectious epidemics and foodborne outbreaks.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Giuseppe Celano, Francesco Maria Calabrese, Giuseppe Riezzo, Benedetta D'Attoma, Antonia Ignazzi, Martina Di Chito, Annamaria Sila, Sara De Nucci, Roberta Rinaldi, Michele Linsalata, Mirco Vacca, Carmen Aurora Apa, Maria De Angelis, Gianluigi Giannelli, Giovanni De Pergola, Francesco Russo
Summary: Recent studies have further deepened the strong connection between gut microbiota and obesity. The effectiveness of the very-low-calorie ketogenic diet (VLCKD) in positively impacting host homeostasis has been measured, but little is known about its modification on the intestinal metabolome. This pilot study analyzed fecal and urinary metabolome in 25 obese patients undergoing VLCKD for eight weeks, revealing specific urinary and fecal metabolites that could be considered as a signature of partial restore toward host eubiosis.
Article
Cell Biology
Caterina Allegretta, Graziana Difonzo, Francesco Caponio, Grazia Tamma, Onofrio Laselva
Summary: The deletion of phenylalanine at position 508 (F508del) causes misfolded CFTR protein, leading to its retention in the ER and degradation. This dysfunction of CFTR channel activity is associated with chronic infection and inflammation, primary causes of lung function decline in CF patients. Additionally, LPS-dependent oxidative stress further reduces CFTR function in airway epithelial cells. Olive leaf extract (OLE) has been found to decrease ROS levels and attenuate inflammatory response in CFBE and HNE cells, mimicking the infection and inflammatory status of CF patients. OLE also restores the decrease in F508del-CFTR function caused by LPS, suggesting its potential for preventing chronic lung damage in CF patients.
Article
Microbiology
Robertina Giacconi, Rossella Donghia, Graziana Arborea, Maria Teresa Savino, Mauro Provinciali, Fabrizia Lattanzio, Giusy Rita Caponio, Sergio Coletta, Antonia Bianco, Maria Notarnicola, Caterina Bonfiglio, Giuseppe Passarino, Patrizia DAquila, Dina Bellizzi, Pasqua Letizia Pesole
Summary: This study found that patients with colorectal cancer have higher levels of bacterial DNA in their plasma compared to healthy individuals, and this is associated with the size of the tumor mass.
Article
Public, Environmental & Occupational Health
Alexander Domnich, Andrea Orsi, Donatella Panatto, Matilde Ogliastro, Alessandra Barca, Fabrizio Bert, Danilo Cereda, Maria Chironna, Claudio Costantino, Daniel Fiacchini, Elena Pariani, Caterina Rizzo, Enrico Volpe, Giancarlo Icardi, FluCoV Study Grp
Summary: This study aimed to assess the impact of local seasonal influenza vaccination coverage rates on pneumonia- and influenza-related mortality among Italian adults aged 65 years and older. The results showed that each 1% increase in vaccination coverage was associated with a 0.6% decrease in mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Anke Stuurman, Antonio Carmona, Jorne Biccler, Alexandre Descamps, Miriam Levi, Ulrike Baum, Ainara Mira-Iglesias, Stefania Bellino, Uy Hoang, Simon de Lusignan, Roberto Bonaiuti, Bruno Lina, Caterina Rizzo, Hanna Nohynek, Javier Diez-Domingo, DRIVE Study Contributors
Summary: The European public-private partnership Development of Robust and Innovative Vaccine Effectiveness (DRIVE) aimed to provide annual estimates of influenza vaccine effectiveness (IVE) for regulatory and public health purposes. DRIVE conducted various studies from 2017 to 2022, collecting data on more than 35,000 patients and 13 influenza vaccines.
FRONTIERS IN PUBLIC HEALTH
(2023)