Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

(2022) Patrick Vagenknecht et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Multi-scale optoacoustic molecular imaging of brain diseases

(2021) Daniel Razansky et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue

(2021) Ruiqing Ni et al.   JOURNAL OF ALZHEIMERS DISEASE

Diffuse optical localization imaging (DOLI) enables noninvasive super-resolution brain angiography in the second near-infrared window

(2021) Quanyu Zhou et al.   Optica

In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice

(2021) Ruiqing Ni et al.   Photoacoustics

Asymmetry of fibrillar plaque burden in amyloid mouse models

(2020) Christian Sacher et al.   JOURNAL OF NUCLEAR MEDICINE

Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy

(2020) Ruiqing Ni et al.   Biomedical Optics Express

Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study

(2020) Wuwei Ren et al.   Journal of Biophotonics

fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis

(2019) Ruiqing Ni et al.   Frontiers in Aging Neuroscience

Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain

(2019) Sven Gottschalk et al.   Nature Biomedical Engineering

Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MRI

(2019) Nan-Jie Gong et al.   NEUROIMAGE

Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies

(2019) Wuwei Ren et al.   Neurophotonics

Optoacoustic mesoscopy for biomedicine

(2019) Murad Omar et al.   Nature Biomedical Engineering

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

(2019) Christian Sacher et al.   JOURNAL OF NUCLEAR MEDICINE

Image scanning microscopy

(2019) Ingo Gregor et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

(2019) Fabian F. Voigt et al.   NATURE METHODS

In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

(2019) Maria Calvo-Rodriguez et al.   Acta Neuropathologica Communications

High‐Speed Large‐Field Multifocal Illumination Fluorescence Microscopy

(2019) Zhenyue Chen et al.   Laser & Photonics Reviews

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

ApoE facilitates the microglial response to amyloid plaque pathology

(2018) Jason D. Ulrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

PET/MRI Hybrid Systems

(2018) Julia G. Mannheim et al.   SEMINARS IN NUCLEAR MEDICINE

Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

(2018) Jennifer D. Whitesell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Applicability of [ 11 C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model

(2017) Anniina Snellman et al.   NEUROBIOLOGY OF AGING

Hybrid system for in vivo epifluorescence and 4D optoacoustic imaging

(2017) Zhenyue Chen et al.   OPTICS LETTERS

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

(2017) Jay Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer

(2017) Yajing Liu et al.   Chemical Science

Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains

(2017) Clémence Dudeffant et al.   Scientific Reports

Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ

(2016) Marcus Bäck et al.   CHEMISTRY-A EUROPEAN JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Quantitative assessment of microvasculopathy in arcAβ mice with USPIO-enhanced gradient echo MRI

(2016) Jan Klohs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

(2016) Dag Sehlin et al.   Nature Communications

Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators

(2016) X Luís Deán-Ben et al.   Light-Science & Applications

Correlation between volumetric oxygenation responses and electrophysiology identifies deep thalamocortical activity during epileptic seizures

(2016) Sven Gottschalk et al.   Neurophotonics

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

(2015) Osama Sabri et al.   Alzheimers & Dementia

Small-Molecule Two-Photon Probes for Bioimaging Applications

(2015) Hwan Myung Kim et al.   CHEMICAL REVIEWS

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

(2015) Hamid Shirani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Advances in real-time multispectral optoacoustic imaging and its applications

(2015) Adrian Taruttis et al.   Nature Photonics

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based drug design identifies polythiophenes as antiprion compounds

(2015) Uli S. Herrmann et al.   Science Translational Medicine

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

(2015) Hye Yun Kim et al.   Nature Communications

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density

(2015) Craig Curtis et al.   JAMA Neurology

Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy

(2015) Nina Jährling et al.   PLoS One

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography

(2014) Xosé Luís Deán-Ben et al.   Light-Science & Applications

Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits

(2013) Sofie Nyström et al.   ACS Chemical Biology

Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells

(2013) F. Lassailly et al.   BLOOD

Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

(2013) R. Ni et al.   BRAIN

Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography

(2013) Stratis Tzoumas et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging

(2013) Jan Klohs et al.   PLoS One

Quantitative spectroscopic photoacoustic imaging: a review

(2012) Ben Cox et al.   JOURNAL OF BIOMEDICAL OPTICS

Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

(2012) L. V. Wang et al.   SCIENCE

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

(2012) L Kulic et al.   Translational Psychiatry

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease

(2011) Anna Lord et al.   AMERICAN JOURNAL OF PATHOLOGY

The Amyloid-Congo Red Interface at Atomic Resolution

(2011) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Long-Term In Vivo Imaging of  -Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral  -Amyloidosis

(2011) J. K. Hefendehl et al.   JOURNAL OF NEUROSCIENCE

Topological basis for the robust distribution of blood to rodent neocortex

(2010) Pablo Blinder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo

(2009) Daniel Razansky et al.   Nature Photonics

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Hybrid FMT–CT imaging of amyloid-β plaques in a murine Alzheimer's disease model

(2008) D HYDE et al.   NEUROIMAGE

Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice

(2007) Marc Dhenain et al.   NEUROBIOLOGY OF AGING