Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner

The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial

(2021) Hagen Schwenzer et al.   CLINICAL CANCER RESEARCH

A Systematic Review of the Biological Effects of Cordycepin

(2021) Masar Radhi et al.   MOLECULES

SynergyFinder 2.0: visual analytics of multi-drug combination synergies

(2020) Aleksandr Ianevski et al.   NUCLEIC ACIDS RESEARCH

Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression

(2020) Carlos Sanchez-Martin et al.   Frontiers in Oncology

Overall survival after treatment for metastatic uveal melanoma

(2019) Elina S. Rantala et al.   MELANOMA RESEARCH

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin

(2019) Jong Bong Lee et al.   Scientific Reports

Obstacles to improving outcomes in the treatment of uveal melanoma

(2018) Katy K. Tsai et al.   CANCER

Adenosine deaminase deficiency: a review

(2018) Aisling M. Flinn et al.   Orphanet Journal of Rare Diseases

Oncogenic signaling in uveal melanoma

(2018) John J. Park et al.   Pigment Cell & Melanoma Research

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart

(2018) Giusy Tassone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors

(2017) Hong-Li Cao et al.   TUMOR BIOLOGY

Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model

(2017) Peng-Yang Hsu et al.   Oncotarget

Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization

(2017) Vladimir A. Kudryavtsev et al.   PLoS One

Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR

(2016) Zheng Wang et al.   MOLECULES

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

(2015) S.-C. Lee et al.   CANCER RESEARCH

Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition

(2015) Isabella C. Taylor et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis

(2015) Kazuki Nakamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cordycepin Suppresses Integrin/FAK Signaling and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

(2014) Wen-Ling Yao et al.   Anti-Cancer Agents in Medicinal Chemistry

Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing

(2014) H Kalirai et al.   BRITISH JOURNAL OF CANCER

Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway

(2014) Ying Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chemical Composition and Nutritional and Medicinal Value of Fruit Bodies and Submerged Cultured Mycelia of Culinary-Medicinal Higher Basidiomycetes Mushrooms

(2014) Nachshol Cohen et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Heat shock protein 27 attenuates neointima formation and accelerates reendothelialization after arterial injury and stent implantation: importance of vascular endothelial growth factor up-regulation

(2013) Xiaoli Ma et al.   FASEB JOURNAL

Notch Signaling Promotes Growth and Invasion in Uveal Melanoma

(2012) L. Asnaghi et al.   CLINICAL CANCER RESEARCH

Cordycepin Stimulated Steroidogenesis in MA-10 Mouse Leydig Tumor Cells through the Protein Kinase C Pathway

(2012) Hsiang-Yin Pao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The genetics of uveal melanoma: an emerging framework for targeted therapy

(2012) J. William Harbour   Pigment Cell & Melanoma Research

Susceptibility of Trypanosoma evansi to cordycepin

(2011) Aleksandro S. Da Silva et al.   BIOMEDICINE & PHARMACOTHERAPY

Histone Deacetylase Inhibitors Induce Growth Arrest and Differentiation in Uveal Melanoma

(2011) S. Landreville et al.   CLINICAL CANCER RESEARCH

Uveal Melanoma: Trends in Incidence, Treatment, and Survival

(2011) Arun D. Singh et al.   OPHTHALMOLOGY

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells

(2010) Eo-Jin Lee et al.   PHYTOTHERAPY RESEARCH

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Tanespimycin: the opportunities and challenges of targeting heat shock protein 90

(2009) Charles Erlichman   EXPERT OPINION ON INVESTIGATIONAL DRUGS