Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase

Role of mitochondrial reactive oxygen species in homeostasis regulation

(2022) Baoyi Zhang et al.   REDOX REPORT

Schizandrol A protects against Aβ1–42-induced autophagy via activation of PI3K/AKT/mTOR pathway in SH-SY5Y cells and primary hippocampal neurons

(2020) Lin Song et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases

(2020) Qiaoyun Song et al.   Translational Neurodegeneration

The role of lysosome in regulated necrosis

(2020) Aqu Alu et al.   Acta Pharmaceutica Sinica B

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly

(2020) Longfei Wang et al.   MOLECULAR CELL

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: therapeutic efficacy of dihydrotanshinone-I

(2020) Hao Zeng et al.   Acta Pharmaceutica Sinica B

The H+ATPase (V-ATPase): from proton pump to signaling complex in health and disease

(2020) Amity F. Eaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer

(2019) Haibing Xian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice

(2019) Shicheng Fan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

(2019) Clive Yik-Sham Chung et al.   Nature Chemical Biology

Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway

(2019) Guangyun Wang et al.   MOLECULES

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A systematic strategy for screening therapeutic constituents of Schisandra chinensis (Turcz.) Baill infiltrated blood–brain barrier oriented in lesions using ethanol and water extracts: a novel perspective for exploring chemical material basis of herb medicines

(2019) Yiwen Zhang et al.   Acta Pharmaceutica Sinica B

The neuroprotective effect of schisandrol A on 6-OHDA-induced PD mice may be related to PI3K/AKT and IKK/IκBα/NF-κB pathway

(2019) Tingxu Yan et al.   EXPERIMENTAL GERONTOLOGY

Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

(2018) Saikat Dewanjee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vacuolar H+-ATPase subunit Vma1p functions as the molecular ligand in the vacuole-targeting fungicidal activity of polymyxin B

(2017) Maki Iida et al.   MICROBIOLOGY-SGM

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

(2016) Valentina Bouché et al.   Autophagy

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Covalent Modulators of the Vacuolar ATPase

(2016) Ying-Chu Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos

(2016) Ling Li et al.   LIFE SCIENCES

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Schizandrin ameliorates ovariectomy-induced memory impairment, potentiates neurotransmission and exhibits antioxidant properties

(2015) Zhong-Jiao Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation

(2015) Yiming Jiang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Effect of Schizandrol A-Induced DNA Methylation on SH-SY5YAB 1-40 Altered Neuronal Cell Line: A Potential Use in Alzheimer’s Disease

(2015) Ming Zhang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

(2015) Lauren A. Barclay et al.   MOLECULAR CELL

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase

(2015) Jianhua Zhao et al.   NATURE

Structure of the Vacuolar H + -ATPase Rotary Motor Reveals New Mechanistic Insights

(2015) Shaun Rawson et al.   STRUCTURE

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice

(2014) Chenning Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions

(2014) E S Shin et al.   Cell Death & Disease

Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor

(2012) Edgardo J. Toro et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3

(2012) J. Hagenbuchner et al.   JOURNAL OF CELL SCIENCE

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Highly Water-Dispersible Biocompatible Magnetite Particles with Low Cytotoxicity Stabilized by Citrate Groups

(2009) Jia Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs

(2009) K. J. Aichberger et al.   BLOOD

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill

(2008) Lian Yu Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY