Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Authors
Keywords
-
Journal
Nature Chemical Biology
Volume 15, Issue 8, Pages 776-785
Publisher
Springer Science and Business Media LLC
Online
2019-07-09
DOI
10.1038/s41589-019-0308-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
- (2019) Carl C. Ward et al. ACS Chemical Biology
- Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target
- (2018) Jessica L. Counihan et al. ACS Chemical Biology
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A toxic mutant huntingtin species is resistant to selective autophagy
- (2017) Yuhua Fu et al. Nature Chemical Biology
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
- (2017) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
- (2017) Brian M. Castellano et al. SCIENCE
- The Lysosome as a Regulatory Hub
- (2016) Rushika M. Perera et al. Annual Review of Cell and Developmental Biology
- Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy
- (2016) Toshiyuki Yano et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Covalent Modulators of the Vacuolar ATPase
- (2016) Ying-Chu Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- An Autophagic Flux Probe that Releases an Internal Control
- (2016) Takeshi Kaizuka et al. MOLECULAR CELL
- Proteome-wide covalent ligand discovery in native biological systems
- (2016) Keriann M. Backus et al. NATURE
- Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase
- (2016) Mohammad T. Mazhab-Jafari et al. NATURE
- Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
- (2016) Vanessa S. Rodrik-Outmezguine et al. NATURE
- Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado–Joseph disease
- (2016) S. Duarte-Silva et al. NEUROSCIENCE
- Ubiquitin-Dependent And Independent Signals In Selective Autophagy
- (2016) Aliaksandr Khaminets et al. TRENDS IN CELL BIOLOGY
- Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic Platforms
- (2015) Daniel Medina-Cleghorn et al. CHEMISTRY & BIOLOGY
- ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity
- (2015) T. Xu et al. Journal of Proteomics
- Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase
- (2015) Jianhua Zhao et al. NATURE
- Compromised autophagy and neurodegenerative diseases
- (2015) Fiona M. Menzies et al. NATURE REVIEWS NEUROSCIENCE
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity
- (2014) Reinhard Dechant et al. MOLECULAR CELL
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures
- (2013) Satoshi Arai et al. NATURE
- Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity
- (2013) D. I. Benjamin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Autophagy modulation as a potential therapeutic target for diverse diseases
- (2012) David C. Rubinsztein et al. NATURE REVIEWS DRUG DISCOVERY
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival
- (2012) F. J. Ramos et al. Science Translational Medicine
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- A cation counterflux supports lysosomal acidification
- (2010) Benjamin E. Steinberg et al. JOURNAL OF CELL BIOLOGY
- The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
- (2010) Jonathan H Fox et al. Molecular Neurodegeneration
- Quantitative reactivity profiling predicts functional cysteines in proteomes
- (2010) Eranthie Weerapana et al. NATURE
- A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
- (2010) A. S. Tsvetkov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
- (2009) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Autophagy Is Required to Maintain Muscle Mass
- (2009) Eva Masiero et al. Cell Metabolism
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now