Schizandrol A protects against Aβ1–42-induced autophagy via activation of PI3K/AKT/mTOR pathway in SH-SY5Y cells and primary hippocampal neurons

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

(2018) Kandhasamy Sowndhararajan et al.   BIOMEDICINE & PHARMACOTHERAPY

Insulin-like growth factor-1 protects SH-SY5Y cells against β-amyloid-induced apoptosis via the PI3K/Akt-Nrf2 pathway

(2017) Zigao Wang et al.   EXPERIMENTAL GERONTOLOGY

Tetramethylpyrazine and Astragaloside IV Synergistically Ameliorate Left Ventricular Remodeling and Preserve Cardiac Function in a Rat Myocardial Infarction Model

(2017) Chuying Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway

(2017) Sasuk Kim et al.   MOLECULAR NEUROBIOLOGY

Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-β1–42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway

(2017) Yang Hui et al.   NEUROCHEMICAL RESEARCH

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1–42-induced oxidative stress

(2017) Faiz Ul Amin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy

(2017) Elisabetta Lauretti et al.   Annals of Clinical and Translational Neurology

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways

(2016) Fangjiao Song et al.   PLoS One

Total Lignans of Schisandra chinensis Ameliorates Aβ1-42-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells

(2016) Xu Zhao et al.   PLoS One

The Effect of Schizandrol A-Induced DNA Methylation on SH-SY5YAB 1-40 Altered Neuronal Cell Line: A Potential Use in Alzheimer’s Disease

(2015) Ming Zhang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Optogenetic control of organelle transport and positioning

(2015) Petra van Bergeijk et al.   NATURE

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

(2015) Vijayasree V. Giridharan et al.   PLoS One

Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway

(2015) Pengjuan Xu et al.   PLoS One

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells

(2014) Zhongfeng Xue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Autophagy via Activation of PI3K/Akt Pathway Contributes to the Protection of Ginsenoside Rb1 against Neuronal Death Caused by Ischemic Insults

(2014) Tianfei Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways

(2014) Zhongshun Guo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons

(2014) Cai-Ping Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The protective mechanism of schisandrin A ind-galactosamine-induced acute liver injury through activation of autophagy

(2014) Ye Lu et al.   PHARMACEUTICAL BIOLOGY

Attenuation of Aβ25–35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways

(2014) Xiangbao Meng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Autophagy: A double-edged sword in Alzheimer’s disease

(2012) Ying-Tsen Tung et al.   JOURNAL OF BIOSCIENCES

Schizandrin Protects Primary Rat Cortical Cell Cultures from Glutamate-Induced Apoptosis by Inhibiting Activation of the MAPK Family and the Mitochondria Dependent Pathway

(2012) Meng-Shiou Lee et al.   MOLECULES

Schizandrin, an Antioxidant Lignan fromSchisandra chinensis,Ameliorates Aβ1–42-Induced Memory Impairment in Mice

(2012) Di Hu et al.   Oxidative Medicine and Cellular Longevity

Schizandrin prevents dexamethasone-induced cognitive deficits

(2012) Xiao Xu et al.   Neuroscience Bulletin

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

(2011) Lin Zheng et al.   Autophagy

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

(2010) Shankar Sadasivan et al.   BMC NEUROSCIENCE

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants

(2010) Kyeong-Ah Jung et al.   MOLECULES

Alzheimer Disease–Associated Peptide, Amyloid β40, Inhibits Vascular Regeneration With Induction of Endothelial Autophagy

(2009) Shin-ichiro Hayashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Review: Autophagy in neurodegeneration: firefighter and/or incendiarist?

(2009) A. Rami   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill

(2008) Lian Yu Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY