Salsalate reduces atherosclerosis through AMPKβ1 in mice

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

(2020) Emily A. Day et al.   BIOCHEMICAL JOURNAL

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

(2020) Carmen Härdtner et al.   BASIC RESEARCH IN CARDIOLOGY

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

(2018) Ryan M. Esquejo et al.   EBioMedicine

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

(2018) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation

(2017) Miao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Barriers to PCSK9 inhibitor prescriptions for patients with high cardiovascular risk: Results of a healthcare provider survey conducted by the National Lipid Association

(2017) Jerome D. Cohen et al.   Journal of Clinical Lipidology

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aspirin inhibits LPS-induced macrophage activation via the NF-κB pathway

(2017) Yitong Liu et al.   Scientific Reports

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

(2016) Brennan K. Smith et al.   DIABETES

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

(2016) Stephen L. Pinkosky et al.   Nature Communications

Effect of Targeting Inflammation With Salsalate

(2016) Thomas H. Hauser et al.   JAMA Cardiology

Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cellsex vivothrough inhibition ofde novolipogenesis

(2015) Andrew J. O’Brien et al.   BIOCHEMICAL JOURNAL

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

(2015) Morgan D. Fullerton et al.   JOURNAL OF LIPID RESEARCH

An Overview of the New Frontiers in the Treatment of Atherogenic Dyslipidemias

(2014) F H Rached et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Treatment strategies in patients with statin intolerance: The Cleveland Clinic experience

(2013) Warner M. Mampuya et al.   AMERICAN HEART JOURNAL

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes

(2013) Joshua I. Barzilay et al.   DIABETES CARE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

AMPK: mediating the metabolic effects of salicylate-based drugs?

(2013) Gregory R. Steinberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

(2010) Josef Ecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis

(2009) S. N. Rajpathak et al.   DIABETES CARE

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science