BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation

Simvastatin inhibits POVPC-mediated induction of endothelial to mesenchymal cell transition

(2021) Yan Li et al.   JOURNAL OF LIPID RESEARCH

The role of BAG3 in health and disease: A “Magic BAG of Tricks”

(2021) Heng Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress

(2021) Roberta Giordo et al.   Frontiers in Cell and Developmental Biology

Pharmacological inhibition of BAG3‐HSP70 with the proposed cancer therapeutic JG‐98 is toxic for cardiomyocytes

(2021) Thomas G. Martin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway

(2021) Yi-hua Zhou et al.   MICROVASCULAR RESEARCH

The role of non-coding RNA network in atherosclerosis

(2020) Yuchan Yuan et al.   LIFE SCIENCES

Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB

(2019) Xi Zhou et al.   Nutrition & Metabolism

Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis

(2019) Qining Yang et al.   PHARMACOLOGICAL RESEARCH

Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart

(2018) Yui Inomata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial–mesenchymal transition in atherosclerosis

(2018) Celine Souilhol et al.   CARDIOVASCULAR RESEARCH

BAG3 promotes the phenotypic transformation of primary rat vascular smooth muscle cells via TRAIL

(2018) Yao Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation of angiotensin II-induced B-cell lymphoma-2-associated athanogene 3 expression in vascular smooth muscle cells

(2018) Shasha Yu et al.   Molecular Medicine Reports

The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis

(2018) M. Wesseling et al.   VASCULAR PHARMACOLOGY

Oxidized low density lipoprotein induces endothelial-to-mesenchymal transition by stabilizing Snail in human aortic endothelial cells

(2018) Qiang Su et al.   BIOMEDICINE & PHARMACOTHERAPY

EndMT: A promising and controversial field

(2018) Lei Hong et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Paeoniflorin attenuates oxidized low‐density lipoprotein‐induced apoptosis and adhesion molecule expression by autophagy enhancement in human umbilical vein endothelial cells

(2018) Yi Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BAG3 plays a central role in proteostasis in the heart

(2017) Wataru Mizushima et al.   JOURNAL OF CLINICAL INVESTIGATION

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

(2017) Paishiun N. Hsieh et al.   Nature Communications

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

(2017) Elisabeth Stürner et al.   Frontiers in Molecular Neuroscience

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis

(2016) Wei Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular and Molecular Connections between Autophagy and Inflammation

(2015) Pierre Lapaquette et al.   MEDIATORS OF INFLAMMATION

MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis

(2015) Yong Zhang et al.   Scientific Reports

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

Mitochondria and Endothelial Function

(2013) Matthew A. Kluge et al.   CIRCULATION RESEARCH

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

BAG3 controls angiogenesis through regulation of ERK phosphorylation

(2012) A Falco et al.   ONCOGENE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Cardiovascular Disease Risk Factors: Epidemiology and Risk Assessment

(2009) Björn Dahlöf   AMERICAN JOURNAL OF CARDIOLOGY

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

(2009) Margit Fuchs et al.   BIOCHEMICAL JOURNAL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH