Pharmacological inhibition of BAG3‐HSP70 with the proposed cancer therapeutic JG‐98 is toxic for cardiomyocytes

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease

(2021) Thomas G. Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover

(2021) Thomas G. Martin et al.   Nature Communications

Metformin rescues muscle function in BAG3 myofibrillar myopathy models

(2020) Avnika A. Ruparelia et al.   Autophagy

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

(2019) Changyi Ji et al.   Autophagy

Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress

(2019) Debapriya Chakraborty et al.   Redox Biology

Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

(2019) Yonghe Ding et al.   Disease Models & Mechanisms

Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1

(2019) Anna E Masser et al.   eLife

CDK5-dependent BAG3 degradation modulates synaptic protein turnover

(2019) Jiechao Zhou et al.   BIOLOGICAL PSYCHIATRY

The critical roles of protein quality control systems in the pathogenesis of heart failure

(2019) Yasuhiro Maejima   Journal of Cardiology

Role of BAG3 in cancer progression: A therapeutic opportunity

(2018) Margot De Marco et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer

(2018) Sarah Sheilds et al.   Oncotarget

Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations

(2018) Julia A. Yaglom et al.   Scientific Reports

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells

(2018) Chandan Kanta Das et al.   NEOPLASIA

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals

(2018) Valerie D. Myers et al.   JAMA Cardiology

Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations

(2018) Fernando Domínguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

BAG3-mediated proteostasis at a glance

(2017) Christina Klimek et al.   JOURNAL OF CELL SCIENCE

BAG3 plays a central role in proteostasis in the heart

(2017) Wataru Mizushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

(2017) Xi Fang et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteostasis in cardiac health and disease

(2017) Robert H. Henning et al.   Nature Reviews Cardiology

The role of heat shock proteins and co-chaperones in heart failure

(2017) Mark J. Ranek et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

(2017) Elisabeth Stürner et al.   Frontiers in Molecular Neuroscience

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

(2015) Anna Ulbricht et al.   Autophagy

BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress

(2015) Young-Hee Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

(2015) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency

(2014) Avnika A. Ruparelia et al.   ACTA NEUROPATHOLOGICA

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy

(2014) Arthur M. Feldman et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation

(2014) Maria Franaszczyk et al.   Journal of Translational Medicine

Tension-induced autophagy

(2013) Anna Ulbricht et al.   Autophagy

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation

(2011) Talita M. Marin et al.   JOURNAL OF CLINICAL INVESTIGATION

BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress

(2010) Akinori Hishiya et al.   CIRCULATION RESEARCH

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Shp2 Negatively Regulates Growth in Cardiomyocytes by Controlling Focal Adhesion Kinase/Src and mTOR Pathways

(2008) Talita M. Marin et al.   CIRCULATION RESEARCH