Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Nuciferine protects against folic acid‐induced acute kidney injury by inhibiting ferroptosis

(2021) Danyu Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

P2X7 receptor signaling promotes inflammation in renal parenchymal cells suffering from ischemia-reperfusion injury

(2021) Yingying Qian et al.   Cell Death & Disease

Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats

(2021) Szu-Jen Yang et al.   Scientific Reports

Farnesoid X receptor promotes renal ischaemia‐reperfusion injury by inducing tubular epithelial cell apoptosis

(2021) Yao Xu et al.   CELL PROLIFERATION

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

(2021) Weiwei Xia et al.   Cell Death & Disease

Lipid Metabolism and Ferroptosis

(2021) Ji-Yoon Lee et al.   Biology-Basel

Ferrostatin-1 attenuates ferroptosis and protects the retina against light-induced retinal degeneration

(2021) Wenyi Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury

(2021) Sho Hasegawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

(2021) Zhenyu Fan et al.   Frontiers in Pharmacology

Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling

(2021) Yu-fan Yang et al.   Journal of Inflammation Research

The role of ferroptosis in breast cancer patients: a comprehensive analysis

(2021) Zeng-Hong Wu et al.   Cell Death Discovery

miR‑30a‑5p mitigates autophagy by regulating the Beclin‑1/ATG16 pathway in renal ischemia/reperfusion injury

(2021) Ye Fang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Recent Approaches to Targeting Canonical NFκB Signaling in the Early Inflammatory Response to Renal IRI

(2021) Shelby Reid et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

(2020) Naoya Yamada et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Targeting of intragraft reactive oxygen species by APP‐103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants

(2020) Koichiro Minami et al.   AMERICAN JOURNAL OF TRANSPLANTATION

VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

(2020) Zhaoxin Hu et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

(2020) Gertrude J. Nieuwenhuijs-Moeke et al.   Journal of Clinical Medicine

Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats

(2020) Naren Bao et al.   MEDIATORS OF INFLAMMATION

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

(2020) Chunyan Wang et al.   Molecular Medicine Reports

Ferroptosis as an emerging target in inflammatory diseases

(2020) Huimin Mao et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Involvement of GPX4 in irisin's protection against ischemia reperfusion‐induced acute kidney injury

(2020) Jia Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis and kidney disease

(2020) Diego Martin-Sanchez et al.   NEFROLOGIA

Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia‐reperfusion

(2020) Yixin Xu et al.   FASEB JOURNAL

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

(2019) Hao Liu et al.   Redox Biology

Renal effects of three endoaortic occlusion strategies in a swine model of hemorrhagic shock

(2019) Guillaume L. Hoareau et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

(2019) Lianjiu Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dexmedetomidine post‐treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF‐1α signalling

(2019) Ke Peng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dexmedetomidine Protects SK-N-SH Nerve Cells from Oxidative Injury by Maintaining Iron Homeostasis

(2019) Lingqin Qiu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway

(2018) Kai Kang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation

(2018) Y. Si et al.   BRITISH JOURNAL OF ANAESTHESIA

Dexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms

(2018) Jianbo Ma et al.   ANESTHESIA AND ANALGESIA

The Possible Pathophysiological Outcomes and Mechanisms of Tourniquet-Induced Ischemia-Reperfusion Injury during Total Knee Arthroplasty

(2018) Prangmalee Leurcharusmee et al.   Oxidative Medicine and Cellular Longevity

Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation

(2017) H. Liang et al.   INFLAMMATION RESEARCH

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats

(2015) Murat Cakir et al.   RENAL FAILURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Iron, oxidative stress, and redox signaling in the cardiovascular system

(2014) Aurélie Gudjoncik et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation

(2013) Yanna Si et al.   Journal of Translational Medicine