A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants

(2022) Bret Sanders et al.   Nature Communications

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2

(2022) Dmitry Prokopenko et al.   MOLECULAR PSYCHIATRY

The mouse cortico–basal ganglia–thalamic network

(2021) Nicholas N. Foster et al.   NATURE

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter

(2020) Eduard Bentea et al.   MOLECULAR PSYCHIATRY

A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum

(2020) Taesun Yoo et al.   Molecular Autism

SNPs in SNCA , MCCC1 , DLG2 , GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population

(2020) Aonan Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

(2020) Lotfi C. Hadjas et al.   NEUROPSYCHOPHARMACOLOGY

The Dorsal Striatum Energizes Motor Routines

(2020) Maria-Teresa Jurado-Parras et al.   CURRENT BIOLOGY

11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

(2020) Joachim Tetteh Siaw et al.   Cell Reports

Genetic variants in glutamate-, Aβ−, and tau-related pathways determine polygenic risk for Alzheimer's disease

(2020) Ted Lawingco et al.   NEUROBIOLOGY OF AGING

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms

(2019) Robert A. McCutcheon et al.   TRENDS IN NEUROSCIENCES

Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks

(2019) Elizabeth K. Ruzzo et al.   CELL

Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism

(2019) Marianna Leonzino et al.   HORMONES AND BEHAVIOR

Neuropilin 2 signaling mediates corticostriatal transmission, spine maintenance, and goal-directed learning in mice

(2019) Maxime Assous et al.   JOURNAL OF NEUROSCIENCE

Dysfunction of the corticostriatal pathway in autism spectrum disorders

(2019) Wei Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer’s Disease

(2018) Christian Wachinger et al.   BIOLOGICAL PSYCHIATRY

DLG2 , but not TMEM229B , GPNMB , and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population

(2018) Hsiu-Chuan Wu et al.   NEUROBIOLOGY OF AGING

Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2−/− Mice

(2018) Changuk Chung et al.   BIOLOGICAL PSYCHIATRY

Direct assessment of presynaptic modulation of cortico-striatal glutamate release in a Huntington’s disease mouse model

(2018) Ellen T. Koch et al.   JOURNAL OF NEUROPHYSIOLOGY

The Thalamostriatal Projections Contribute to the Initiation and Execution of a Sequence of Movements

(2018) Edgar Díaz-Hernández et al.   NEURON

An opposing function of paralogs in balancing developmental synapse maturation

(2018) Plinio D. Favaro et al.   PLOS BIOLOGY

Striato-cortical connections in Parkinson's and Alzheimer's diseases: Relation to cognition

(2017) Lubomira Anderkova et al.   MOVEMENT DISORDERS

Novel promoters and coding first exons in DLG2 linked to developmental disorders and intellectual disability

(2017) Claudio Reggiani et al.   Genome Medicine

Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93

(2017) Daniela Winkler et al.   BEHAVIOURAL BRAIN RESEARCH

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

(2016) David C. Hondius et al.   Alzheimers & Dementia

Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease

(2016) Toru Ishii et al.   JOURNAL OF NEUROLOGY

Hyperkinetic disorders and loss of synaptic downscaling

(2016) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Striatal Circuits as a Common Node for Autism Pathophysiology

(2016) Marc V. Fuccillo   Frontiers in Neuroscience

Striatal circuits, habits, and implications for obsessive–compulsive disorder

(2015) Eric Burguière et al.   CURRENT OPINION IN NEUROBIOLOGY

Common genetic variants influence human subcortical brain structures

(2015) Derrek P. Hibar et al.   NATURE

PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density

(2015) Xiaobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Striatum: Where Skills and Habits Meet

(2015) Ann M. Graybiel et al.   Cold Spring Harbor Perspectives in Biology

Layer 5 Pyramidal Neurons’ Dendritic Remodeling and Increased Microglial Density in Primary Motor Cortex in a Murine Model of Facial Paralysis

(2015) Diana Urrego et al.   Biomed Research International

Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors

(2014) Patrick E. Rothwell et al.   CELL

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Identification of risk genes for autism spectrum disorder through copy number variation analysis in Austrian families

(2014) Gerald Egger et al.   NEUROGENETICS

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

Evidence for Corticostriatal Dysfunction During Cognitive Skill Learning in Adolescent Siblings of Patients With Childhood-Onset Schizophrenia

(2013) Dana Wagshal et al.   SCHIZOPHRENIA BULLETIN

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

(2013) S. E. Ahmari et al.   SCIENCE

The role of the striatum in social behavior

(2013) Raymundo Báez-Mendoza et al.   Frontiers in Neuroscience

Anatomic and Molecular Development of Corticostriatal Projection Neurons in Mice

(2012) U. Shivraj Sohur et al.   CEREBRAL CORTEX

TrkA Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry

(2012) E. Sanchez-Ortiz et al.   JOURNAL OF NEUROSCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Reduced Proactive Inhibition in Schizophrenia Is Related to Corticostriatal Dysfunction and Poor Working Memory

(2011) Bram B. Zandbelt et al.   BIOLOGICAL PSYCHIATRY

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

(2010) Sergey V Shmelkov et al.   NATURE MEDICINE

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

(2008) T. Walsh et al.   SCIENCE