Genetic variants in glutamate-, Aβ−, and tau-related pathways determine polygenic risk for Alzheimer's disease

Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer’s disease cerebrospinal fluid

(2019) Alberto Lleó et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

(2019) Pierre Dourlen et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

(2019) Sultan Chaudhury et al.   Translational Psychiatry

PRSice-2: Polygenic Risk Score software for biobank-scale data

(2019) Shing Wan Choi et al.   GigaScience

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Genotyping of the Alzheimer’s Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort

(2018) Keeley J. Brookes et al.   JOURNAL OF ALZHEIMERS DISEASE

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

(2018) Sven J van der Lee et al.   LANCET NEUROLOGY

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease

(2018) Sultan Chaudhury et al.   NEUROBIOLOGY OF AGING

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

(2018) Iris J. Broce et al.   ACTA NEUROPATHOLOGICA

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases

(2017) Cornelis Blauwendraat et al.   NEUROBIOLOGY OF AGING

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

(2017) Albert Giralt et al.   Nature Communications

Novel promoters and coding first exons in DLG2 linked to developmental disorders and intellectual disability

(2017) Claudio Reggiani et al.   Genome Medicine

APOE -Sensitive Cholinergic Sprouting Compensates for Hippocampal Dysfunctions Due to Reduced Entorhinal Input

(2016) Jean-Bastien Bott et al.   JOURNAL OF NEUROSCIENCE

Assessment of the genetic variance of late-onset Alzheimer's disease

(2016) Perry G. Ridge et al.   NEUROBIOLOGY OF AGING

Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia

(2015) Hieab H.H. Adams et al.   Alzheimers & Dementia

PRROC: computing and visualizing precision-recall and receiver operating characteristic curves in R

(2015) Jan Grau et al.   BIOINFORMATICS

Common polygenic variation enhances risk prediction for Alzheimer’s disease

(2015) Valentina Escott-Price et al.   BRAIN

Genomic risk prediction of complex human disease and its clinical application

(2015) Gad Abraham et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

(2012) Vanja Duric et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease

(2012) E. Rodríguez-Rodríguez et al.   JOURNAL OF NEURAL TRANSMISSION

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Synaptic scaffold evolution generated components of vertebrate cognitive complexity

(2012) Jess Nithianantharajah et al.   NATURE NEUROSCIENCE

Reduction of AP180 and CALM Produces Defects in Synaptic Vesicle Size and Density

(2012) Ronald S. Petralia et al.   NEUROMOLECULAR MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function

(2010) N. K. Hussain et al.   JOURNAL OF NEUROSCIENCE

Cotrafficking of SV2 and Synaptotagmin at the Synapse

(2010) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS