Recent Advances and the Mechanism of Astaxanthin in Ophthalmological Diseases

Astaxanthin as a Modulator of Nrf2, NF-κB, and Their Crosstalk: Molecular Mechanisms and Possible Clinical Applications

(2022) Sergio Davinelli et al.   MOLECULES

Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine

(2022) Jiawei Ling et al.   Frontiers in Medicine

Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease

(2022) Lei Tian et al.   Frontiers in Nutrition

Inhibition of the NR2B–PSD95 Interaction Exerts Neuroprotective Effects on Retinal Ischemia–Reperfusion Injury

(2022) Xuejin Zhang et al.   NEUROSCIENCE

Docetaxel maintenance therapy versus best supportive care after first-line chemotherapy with different dose docetaxel plus cisplatin for advanced non-small cell lung cancer (TFINE study, CTONG-0904): an open-label, randomized, phase III trial

(2021) Li Zhang et al.   Annals of Translational Medicine

Astaxanthin mediated regulation of VEGF through HIF1α and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model

(2021) Rajasekar Janani et al.   EXPERIMENTAL EYE RESEARCH

Impact of preconditioning stem cells with all-trans retinoic acid signaling pathway on cisplatin-induced nephrotoxicity by down-regulation of TGFβ1, IL-6, and caspase-3 and up-regulation of HIF1α and VEGF

(2021) Mohsen Khedr et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders

(2021) Zubda Yaqoob et al.   Food Science & Nutrition

Astaxanthin attenuates hepatic damages and mitochondrial dysfunction in nonalcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway

(2020) Liwei Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus

(2020) Ming Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model

(2020) Chao-Wen Lin et al.   Marine Drugs

Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma

(2020) Kasumi Kikuchi et al.   Journal of Ophthalmology

Astaxanthin protects retinal ganglion cells from acute glaucoma via the Nrf2/HO-1 pathway

(2020) Yan Li et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Inhibition of NF-κB signaling pathway by astaxanthin supplementation for prevention of heat stress–induced inflammatory changes and apoptosis in Karan Fries heifers

(2019) Sunil Kumar et al.   TROPICAL ANIMAL HEALTH AND PRODUCTION

ACUTE RETINAL ISCHEMIA IN CENTRAL VERSUS BRANCH RETINAL ARTERY OCCLUSION

(2019) Egbert Matthé et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina

(2019) Mohammad Shamsul Ola et al.   NEUROTOXICITY RESEARCH

Changes in conjunctival epithelial cells after treatment with 0.2% xanthan gum eye drops in mild-moderate dry eye

(2019) Elisa Imelde Postorino et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Effect of taxifolin on development of retinopathy in alloxan-induced diabetic rats

(2019) Ibrahim Ahiskali et al.   Cutaneous and Ocular Toxicology

Antioxidant effects of piperine in in-vivo chick embryo cataract model induced by steroids

(2019) Ayhan Vurmaz et al.   Cutaneous and Ocular Toxicology

Precision medicine to prevent glaucoma-related blindness

(2019) Sayoko E. Moroi et al.   CURRENT OPINION IN OPHTHALMOLOGY

Suboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific CTL clones

(2019) Mark A. Grossman et al.   AIDS

Comparative study between lutein and its liposomal form on cisplatin-induced retinal injury in rabbits

(2019) Amal E. Ibrahim et al.   Cutaneous and Ocular Toxicology

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on cataract

(2019) Thomas Tenkate et al.   ENVIRONMENT INTERNATIONAL

Related Risk Factors between Subclinical Carotid Atherosclerosis and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetes Mellitus in China

(2019) Fengqi Guo et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Glaucoma progression analysis by Spectral-Domain Optical Coherence Tomography (SD-OCT)

(2019) J.-P. Renard et al.   JOURNAL FRANCAIS D OPHTALMOLOGIE

Astaxanthin inhibits hallmarks of cancer by targeting the PI3K/NF-κΒ/STAT3 signalling axis in oral squamous cell carcinoma models

(2019) Jaganathan Kowshik et al.   IUBMB LIFE

Autoimmune epithelitis (Sjögren's syndrome); the impact of metabolic status of glandular epithelial cells on auto-immunogenicity

(2019) Stergios Katsiougiannis et al.   JOURNAL OF AUTOIMMUNITY

ER-mediated anti-tumor effects of shikonin on breast cancer

(2019) Yang Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Heterotrophic cultivation of microalgae for pigment production: A review

(2018) Jianjun Hu et al.   BIOTECHNOLOGY ADVANCES

Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model

(2018) Ali Küçüködük et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Short-Term Administration of Astaxanthin Attenuates Retinal Changes in Diet-Induced Diabetic Psammomys obesus

(2018) Basma Baccouche et al.   CURRENT EYE RESEARCH

Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study

(2018) Ayano Imai et al.   Nutrients

The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats

(2018) Yonghao Feng et al.   Frontiers in Pharmacology

Pathological Perturbations in Diabetic Retinopathy: Hyperglycemia, AGEs, Oxidative Stress and Inflammatory Pathways

(2018) Nikhil Shri Sahajpal et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The protective effects of astaxanthin against cisplatin-induced retinal toxicity

(2018) Hüseyin Fındık et al.   Cutaneous and Ocular Toxicology

On the Neuroprotective Role of Astaxanthin: New Perspectives?

(2018) Christian Galasso et al.   Marine Drugs

Astaxanthin: A mechanistic review on its biological activities and health benefits

(2018) Sajad Fakhri et al.   PHARMACOLOGICAL RESEARCH

Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells

(2018) Suhn Kim et al.   Nutrients

Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity

(2018) Ji Hye Han et al.   Scientific Reports

Astaxanthin protects lipopolysaccharide-induced inflammatory response in Channa argus through inhibiting NF-κB and MAPKs signaling pathways

(2018) Mu-Yang Li et al.   FISH & SHELLFISH IMMUNOLOGY

Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration

(2017) Yuki Inoue et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice

(2017) Fumiya Harada et al.   Oxidative Medicine and Cellular Longevity

Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model

(2017) Marina Renner et al.   Frontiers in Cellular Neuroscience

Population-based survey of prevalence, causes, and risk factors for blindness and visual impairment in an aging Chinese metropolitan population

(2017)   International Journal of Ophthalmology

Analysis of antioxidative factors related to AMD risk development in the polish patients

(2016) Malgorzata Mrowicka et al.   ACTA OPHTHALMOLOGICA

Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models

(2016) Tomohiro Otsuka et al.   CURRENT EYE RESEARCH

The effect of astaxanthin on vascular endothelial growth factor (VEGF) levels and peroxidation reactions in the aqueous humor

(2016) Hirotaka Hashimoto et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Astaxanthin affects oxidative stress and hyposalivation in aging mice

(2016) Manatsu Kuraji et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Review of genotoxicity and rat carcinogenicity investigations with astaxanthin

(2016) James A. Edwards et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats

(2016) Po-Ting Yeh et al.   PLoS One

Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo

(2015) Kuan-Hung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of astaxanthin on the aging rat brain: gender-related differences in modulating inflammation

(2015) Marta Balietti et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases

(2015) Haijian Wu et al.   Marine Drugs

Effect of Astaxanthin on Cataract Formation Induced by Glucocorticoids in the Chick Embryo

(2014) Sayano Ishikawa et al.   CURRENT EYE RESEARCH

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

(2013) K. Kavitha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Protective Effects of a Dietary Carotenoid, Astaxanthin, Against Light-Induced Retinal Damage

(2013) Tomohiro Otsuka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Astaxanthin Attenuates the Apoptosis of Retinal Ganglion Cells in db/db Mice by Inhibition of Oxidative Stress

(2013) Ling-Yan Dong et al.   Marine Drugs

Carotenoids in Age-Related Maculopathy Italian Study (CARMIS): Two-Year Results of a Randomized Study

(2011) et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

The Mechanisms and Consequences of Ultraviolet-Induced Immunosuppression in the Skin and Eye

(2011) Mary Norval   Eye & Contact Lens-Science and Clinical Practice

Astaxanthin increases choroidal blood flow velocity

(2011) Michiyuki Saito et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo

(2010) Yoshimi Nakajima et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure

(2010) Aysegul Cort et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis

(2008) Burde Sandesh Kamath et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats

(2008) John S. Stewart et al.   FOOD AND CHEMICAL TOXICOLOGY

Carotenoids and Antioxidants in Age-Related Maculopathy Italian Study

(2007) Vincenzo Parisi et al.   OPHTHALMOLOGY