Review
Biochemistry & Molecular Biology
Yoko Ogawa, Tsutomu Takeuchi, Kazuo Tsubota
Summary: Autoimmune epithelitis and chronic inflammation are characteristic features of the immune pathogenesis of Sjogren's syndrome (SS)-related dry eye disease, affecting the secretion of tear fluid and mucin. Dysfunction of ocular surface epithelium can lead to dry eye disease, with potential targets for treatment including various molecules in tear film, cornea, conjunctiva, lacrimal glands, and meibomian glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Qing Zheng, Lingyu Liu, Bin Wang, Yan He, Mengqin Zhang, Guixiu Shi
Summary: The key pathogenic pathway in primary Sjogren's syndrome (SjS) is the activation of the interferon (IFN) pathway, which was identified through bioinformatics analysis. The phosphorylated signal transducer and activator of transcription proteins 1 (p-STAT1) was found to be a valuable biomarker for diagnosing SjS, particularly in salivary gland samples with negative lymphatic foci.
Article
Pharmacology & Pharmacy
Przemyslaw Zdziarski, Mariola Pasciak, Andrzej Gamian
Summary: This study describes a simple, universal, and cost-effective method for microbiome analysis in clinical trials, emphasizing the safety, immunomodulation, and microbiological outcomes of topical steroids.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
Summary: This study identifies ten novel genetic risk regions associated with Sjogren's disease, implicating genes involved in immune and salivary gland function.
NATURE COMMUNICATIONS
(2022)
Article
Rheumatology
Valentina Pucino, Jason D. Turner, Saba Nayar, Florian Kollert, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Summary: This study aimed to compare clinical and proteomic predictors of primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), and identify the key predictors of symptoms. The results showed that obesity-related metabolic factors may regulate symptoms in sicca, while further research is needed to explore the non-inflammatory drivers of high symptom burden in SjS.
Review
Biochemistry & Molecular Biology
Weizhen Zeng, Xinyao Zhou, Sulan Yu, Ruihua Liu, Chrystie Wan Ning Quek, Haozhe Yu, Ryan Yong Kiat Tay, Xiang Lin, Yun Feng
Summary: This article discusses the treatment of Sjogren's syndrome, focusing on new drug targets and the latest clinical trials. The study found that current trials overlook the non-glandular symptoms that often accompany the disease, such as fatigue, depression, and anxiety. Emerging biological agents targeting dryness and these symptoms have been studied and proven effective and safe. Additionally, it is suggested to create better grading systems to assess disease activity and severity, and the future of treatment may lie in gene, stem-cell, and tissue-engineering therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yung-Hsiang Chao, Chin-Hsiu Liu, Yu-An Pan, Fu-Shun Yen, Jeng-Yuan Chiou, James Cheng-Chung Wei
Summary: This population-based cohort study found that patients with a history of endometriosis have an increased risk of developing Sjogren's syndrome, especially within the first five years after diagnosis, and in the age group of 20-39.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Manuel Ramos-Casals, Nihan Acar-Denizli, Arjan Vissink, Pilar Brito-Zeron, Xiaomei Li, Francesco Carubbi, Roberta Priori, Natasa Toplak, Chiara Baldini, Enrique Faugier-Fuentes, Aike A. Kruize, Thomas Mandl, Minako Tomiita, Saviana Gandolfo, Kunio Hashimoto, Gabriela Hernandez-Molina, Benedikt Hofauer, Samara Mendieta-Zeron, Astrid Rasmussen, Pulukool Sandhya, Damien Sene, Virginia Fernandes Moca Trevisani, David Isenberg, Erik Sundberg, Sandra G. Pasoto, Agata Sebastian, Yasunori Suzuki, Soledad Retamozo, Bei Xu, Roberto Giacomelli, Angelica Gattamelata, Masa Bizjak, Stefano Bombardieri, Richard-Eduardo Loor-Chavez, Anneline Hinrichs, Peter Olsson, Hendrika Bootsma, Scott M. Lieberman
Summary: Childhood-onset primary Sjogren's syndrome is characterized by sicca features, parotid enlargement, and systemic disease, with age at diagnosis influencing the phenotypic expression of the disease. Symptom presentation includes dry mouth, dry eyes, positive ANA, anti-Ro/La antibodies, and positive RF, among others.
Article
Immunology
Yu Cao, Hao Lu, Wangzi Xu, Ming Zhong
Summary: The study reveals a causal relationship between gut microbiota composition and Sjogren's Syndrome risk, with some microbial species positively correlated and others negatively correlated. Additionally, four genes related to gut microbiota were found to have a causal effect on Sjogren's Syndrome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tian Sun, Shanshan Liu, Guangxia Yang, Rujie Zhu, Zutong Li, Genhong Yao, Hongwei Chen, Lingyun Sun
Summary: This study investigates the role of the inhibitory receptor Tim-3 in Sjogren's syndrome (SS) and mesenchymal stem cell (MSC) treatment. The results show that Tim-3 is downregulated in T cells of SS patients and mice, and MSC transplantation can ameliorate SS-like symptoms and pathological changes by modulating Tim-3 expression. Tim-3 is also crucial for the inhibitory effect of MSCs on PBMC proliferation. These findings provide a novel mechanism of MSC treatment and suggest a potential combination therapy for SS targeting the inhibitory receptor.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
J. H. Koh, Y. Park, J. Lee, S-H Park, S-K Kwok
Summary: Persistent hypergammaglobulinaemia is associated with salivary gland and solid organ damage, while decreased IgG levels may attenuate the progression to solid organ dysfunction.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Sherri Longobardi, Charmaine Lopez-Davis, Bhuwan Khatri, Constantin Georgescu, Cherilyn Pritchett-Frazee, Christina Lawrence, Astrid Rasmussen, Lida Radfar, Robert Hal Scofield, Alan N. Baer, Susan A. Robinson, Erika Darrah, Robert C. Axtell, Gabriel Pardo, Jonathan D. Wren, Kristi A. Koelsch, Joel M. Guthridge, Judith A. James, Christopher J. Lessard, Amy Darise Farris
Summary: This study identified autoantibodies in anti-Ro/SS-A negative primary Sjogren's syndrome (SS), providing a new approach for diagnosing Ro-negative SS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Geriatrics & Gerontology
Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang, Haixia Li
Summary: This study investigated the clinical data and laboratory markers associated with renal function damage or renal involvement in pSS patients. The results showed that age, urea, chlorine, and anti-SSA were highly associated with renal injury in pSS. Early screening for autoantibodies would be meaningful for evaluation and prevention of renal injury in pSS.
Article
Rheumatology
Alexandra Kachaner, Elisabeth Berge, Frederic Desmoulins, Christine Le Pajolec, Antoine Rousseau, Marc Labetoulle, Gaetane Nocturne, Xavier Mariette, Raphaele Seror
Summary: This study describes primary Sjogren's disease patients who do not have or have a low level of dryness, and compares them with Sjogren's disease patients who have oral or ocular dryness features.
Review
Biochemistry & Molecular Biology
Yuko Okawa, Kenji Ihara
Summary: Sjogren's syndrome is a chronic autoimmune disease that affects the salivary and lachrymal glands. It can be classified into primary and secondary forms, with varying degrees of severity. Sensorineural hearing loss can occur in some cases. This review article provides a comprehensive overview of the pathology, clinical manifestations, inner ear diseases, immunological characteristics, pathophysiology, treatment options, and future directions of Sjogren's syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)