Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors

Sampling alternative conformational states of transporters and receptors with AlphaFold2

(2022) Diego del Alamo et al.   eLife

RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior

(2021) Gal Warhaftig et al.   Translational Psychiatry

The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge‐like ethanol drinking

(2021) Rayane I. Tabbara et al.   ADDICTION BIOLOGY

Cryo-EM structure of the human histamine H1 receptor/Gq complex

(2021) Ruixue Xia et al.   Nature Communications

RNA editing of 5‐HT 2C R impairs insulin secretion of pancreatic beta cells via altered store‐operated calcium entry

(2021) Ke‐Yun Xie et al.   FASEB JOURNAL

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

Structure, function and pharmacology of human itch GPCRs

(2021) Can Cao et al.   NATURE

Cholesterol-mediated oligomerization pathways of serotonin G-coupled receptor 5-HT2C

(2020) Luca Massaccesi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

(2020) Reid H. J. Olsen et al.   Nature Chemical Biology

GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps

(2020) Michael J. Robertson et al.   STRUCTURE

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Topaz-Denoise: general deep denoising models for cryoEM and cryoET

(2020) Tristan Bepler et al.   Nature Communications

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

(2020) Ali Punjani et al.   NATURE METHODS

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

(2019) Konstantin Licht et al.   GENOME RESEARCH

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs

(2019) Tristan Bepler et al.   NATURE METHODS

Logomaker: beautiful sequence logos in Python

(2019) Ammar Tareen et al.   BIOINFORMATICS

5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

(2018) Yao Peng et al.   CELL

RNA Editing and Retrotransposons in Neurology

(2018) Heinz Krestel et al.   Frontiers in Molecular Neuroscience

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Effects of lorcaserin on reinstatement of responding previously maintained by cocaine or remifentanil in rhesus monkeys.

(2018) Lisa R. Gerak et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Inosine induces context-dependent recoding and translational stalling

(2018) Konstantin Licht et al.   NUCLEIC ACIDS RESEARCH

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

GPCRdb in 2018: adding GPCR structure models and ligands

(2017) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A-to-I editing of microRNAs in the mammalian brain increases during development

(2012) Y. Ekdahl et al.   GENOME RESEARCH

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High-Throughput Sequencing in Psychiatric Disorders

(2012) Hu Zhu et al.   PLoS One

Quantitative analysis of 5HT2C receptor RNA editing patterns in psychiatric disorders

(2011) Richard T. O'Neil et al.   NEUROBIOLOGY OF DISEASE

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination and Reinstatement: Relationship to Feeding Behavior and Impulse Control

(2011) Guy A Higgins et al.   NEUROPSYCHOPHARMACOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome

(2010) Michael V. Morabito et al.   NEUROBIOLOGY OF DISEASE

Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method

(2010) A. I. Abbas et al.   NUCLEIC ACIDS RESEARCH

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Simple Model of Backbone Flexibility Improves Modeling of Side-chain Conformational Variability

(2008) Gregory D. Friedland et al.   JOURNAL OF MOLECULAR BIOLOGY

Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain Prediction

(2008) Colin A. Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

Dysregulated Editing of Serotonin 2C Receptor mRNAs Results in Energy Dissipation and Loss of Fat Mass

(2008) Y. Kawahara et al.   JOURNAL OF NEUROSCIENCE