Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice

Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors

(2022) Fyza Y. Shaikh et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Automated quality control and cell identification of droplet-based single-cell data using dropkick

(2021) Cody N Heiser et al.   GENOME RESEARCH

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

(2021) Bob Chen et al.   CELL

Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer

(2020) Sarah Tomkovich et al.   mSystems

Clostridioides difficileinfection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

(2020) Steven J. Mileto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

(2020) Thergiory Irrazabal et al.   Nature Communications

A Quantitative Framework for Evaluating Single-Cell Data Structure Preservation by Dimensionality Reduction Techniques

(2020) Cody N. Heiser et al.   Cell Reports

Dual indexed library design enables compatibility of in-Drop single-cell RNA-sequencing with exAMP chemistry sequencing platforms

(2020) Austin N. Southard-Smith et al.   BMC GENOMICS

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation

(2020) Amrita Banerjee et al.   GASTROENTEROLOGY

Host–microbiota maladaptation in colorectal cancer

(2020) Alina Janney et al.   NATURE

The Intestinal Microbiota and Colorectal Cancer

(2020) Yiwen Cheng et al.   Frontiers in Immunology

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

(2019) Sarah Tomkovich et al.   JOURNAL OF CLINICAL INVESTIGATION

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

(2019) Andrew Maltez Thomas et al.   NATURE MEDICINE

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

(2019) Jakob Wirbel et al.   NATURE MEDICINE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

(2018) Liam Chung et al.   Cell Host & Microbe

Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B

(2018) Peng Chen et al.   SCIENCE

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Analysis ofFusobacteriumpersistence and antibiotic response in colorectal cancer

(2017) Susan Bullman et al.   SCIENCE

Clostridium difficile colonization in preoperative colorectal cancer patients

(2017) Yi Zheng et al.   Oncotarget

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

(2017) Julia L. Drewes et al.   npj Biofilms and Microbiomes

Reduction of Murine Colon Tumorigenesis Driven by EnterotoxigenicBacteroides fragilisUsing Cefoxitin Treatment

(2016) Christina E. DeStefano Shields et al.   JOURNAL OF INFECTIOUS DISEASES

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

(2016) E Thiele Orberg et al.   Mucosal Immunology

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

(2016) Liang Tao et al.   NATURE

Metabolism Links Bacterial Biofilms and Colon Carcinogenesis

(2015) Caroline H. Johnson et al.   Cell Metabolism

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

(2015) Glen P. Carter et al.   mBio

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

Clostridium difficile Toxin A Attenuates Wnt/β-Catenin Signaling in Intestinal Epithelial Cells

(2014) Bruno Bezerra Lima et al.   INFECTION AND IMMUNITY

Microbiota organization is a distinct feature of proximal colorectal cancers

(2014) Christine M. Dejea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the gut microbiome following colonization with human feces determines colonic tumor burden

(2014) Nielson T Baxter et al.   Microbiome

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

(2013) Aleksandar D. Kostic et al.   Cell Host & Microbe

Improving pan-genome annotation using whole genome multiple alignment

(2011) Samuel V Angiuoli et al.   BMC BIOINFORMATICS

Evaluation of new selective culture media and a rapid fluorescence in situ hybridization assay for identification of Clostridium difficile from stool samples

(2009) K. Bloedt et al.   JOURNAL OF MEDICAL MICROBIOLOGY

FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix

(2009) M. N. Price et al.   MOLECULAR BIOLOGY AND EVOLUTION

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE