Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein

Granulocyte-macrophage colony-stimulating factor mRNA and Neuroprotective Immunity in Parkinson's disease

(2021) Katherine E. Olson et al.   BIOMATERIALS

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

(2021) David Zemmour et al.   NATURE IMMUNOLOGY

A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus

(2021) Allison August et al.   NATURE MEDICINE

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

(2020) Michael Delacher et al.   IMMUNITY

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

(2020) Lars Fugger et al.   CELL

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins

(2020) Aazam Ghelani et al.   Frontiers in Immunology

Impact of mRNA chemistry and manufacturing process on innate immune activation

(2020) Jennifer Nelson et al.   Science Advances

T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation

(2020) Saskia Hemmers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting co-stimulatory molecules in autoimmune disease

(2020) Natalie M. Edner et al.   NATURE REVIEWS DRUG DISCOVERY

muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data

(2020) Helena L. Crowell et al.   Nature Communications

De novo design of potent and selective mimics of IL-2 and IL-15

(2019) Daniel-Adriano Silva et al.   NATURE

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

(2019) Li-Ming Gan et al.   Nature Communications

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

(2019) Susannah L. Hewitt et al.   Science Translational Medicine

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

(2019) Ricardo J. Miragaia et al.   IMMUNITY

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

The barcode, UMI, set format and BUStools

(2019) Páll Melsted et al.   BIOINFORMATICS

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges

(2019) Ilenia Pacella et al.   Frontiers in Immunology

Orchestrating single-cell analysis with Bioconductor

(2019) Robert A. Amezquita et al.   NATURE METHODS

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

(2018) David Zemmour et al.   NATURE IMMUNOLOGY

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

Unexpected Help: Follicular Regulatory T Cells in the Germinal Center

(2018) Markus M. Xie et al.   Frontiers in Immunology

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

(2018) Laurence B. Peterson et al.   JOURNAL OF AUTOIMMUNITY

A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers

(2017) James Badger Wing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing the structure of RNA-seq expression data using grade of membership models

(2017) Kushal K. Dey et al.   PLoS Genetics

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

(2016) John Koreth et al.   BLOOD

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Regulation of the T Cell Response by CD39

(2016) Maisa C. Takenaka et al.   TRENDS IN IMMUNOLOGY

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells

(2015) Charles J.M. Bell et al.   JOURNAL OF AUTOIMMUNITY

Computational assignment of cell-cycle stage from single-cell transcriptome data

(2015) Antonio Scialdone et al.   METHODS

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Restoring the balance: immunotherapeutic combinations for autoimmune disease

(2014) D. E. Smilek et al.   Disease Models & Mechanisms

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Effects of Low-Dose Recombinant Interleukin 2 to Promote T-Regulatory Cells in Alopecia Areata

(2014) Emeline Castela et al.   JAMA Dermatology

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells

(2014) Akio Ohta et al.   Frontiers in Immunology

CD4+CD45RA−FoxP3highactivated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes

(2013) F. Haseda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Transcriptional regulation of the NKT cell lineage

(2013) Michael G Constantinides et al.   CURRENT OPINION IN IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

(2013) Agnès Hartemann et al.   Lancet Diabetes & Endocrinology

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients

(2010) J. A. G. van Roon et al.   RHEUMATOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)

(2008) M. Bonelli et al.   INTERNATIONAL IMMUNOLOGY