Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle

(2020) Emma Rybalka et al.   Cells

Sirt7 inhibits Sirt1-mediated activation of Suv39h1

(2018) Poonam Kumari et al.   CELL CYCLE

Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology

(2018) Alessandro Ianni et al.   PEDIATRIC CARDIOLOGY

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

(2017) Giovanna Sociali et al.   FASEB JOURNAL

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

(2017) Antonia Cagnetta et al.   HAEMATOLOGICA

Young Investigator Colloquia

(2017)   JOURNAL OF NEUROCHEMISTRY

Identification of serum protein biomarkers for utrophin based DMD therapy

(2017) S. Guiraud et al.   NEUROMUSCULAR DISORDERS

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches

(2017) Virginie Mariot et al.   Nature Communications

In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells

(2017) Léo Machado et al.   Cell Reports

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

(2017) Antonia Cagnetta et al.   HAEMATOLOGICA

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy

(2017) Sadhana A. Samant et al.   Scientific Reports

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells

(2016) Courtney S. Young et al.   Cell Stem Cell

Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation

(2016) Verawan Boonsanay et al.   Cell Stem Cell

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

SIRT1: A Novel Target for the Treatment of Muscular Dystrophies

(2016) Atsushi Kuno et al.   Oxidative Medicine and Cellular Longevity

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease

(2016) Marie-Claude Sincennes et al.   Stem Cells Translational Medicine

Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation

(2015) L. Skalska et al.   EMBO JOURNAL

Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration

(2015) Thomas C. Roberts et al.   HUMAN MOLECULAR GENETICS

Effect of genetic background on the dystrophic phenotype inmdxmice

(2015) William D. Coley et al.   HUMAN MOLECULAR GENETICS

Second-generation compound for the modulation of utrophin in the therapy of DMD

(2015) Simon Guiraud et al.   HUMAN MOLECULAR GENETICS

Linker histone H1 and H3K56 acetylation are antagonistic regulators of nucleosome dynamics

(2015) Morgan Bernier et al.   Nature Communications

Prmt5 is a regulator of muscle stem cell expansion in adult mice

(2015) Ting Zhang et al.   Nature Communications

Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche

(2015) Masahiko Yamaguchi et al.   Cell Reports

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

MSTN, mTOR and FoxO4 Are Involved in the Enhancement of Breast Muscle Growth by Methionine in Broilers with Lower Hatching Weight

(2014) Chao Wen et al.   PLoS One

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

(2014) Angeliki Chalkiadaki et al.   PLoS Genetics

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells

(2013) Stefan Günther et al.   Cell Stem Cell

The mdx mouse model as a surrogate for Duchenne muscular dystrophy

(2013) Terence A. Partridge   FEBS Journal

Kraken: A set of tools for quality control and analysis of high-throughput sequence data

(2013) Matthew P.A. Davis et al.   METHODS

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis

(2013) Brian J Haas et al.   Nature Protocols

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy

(2012) Thomas C Roberts et al.   Molecular Therapy-Nucleic Acids

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Daily Treatment with SMTC1100, a Novel Small Molecule Utrophin Upregulator, Dramatically Reduces the Dystrophic Symptoms in the mdx Mouse

(2011) Jonathon M. Tinsley et al.   PLoS One

Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

(2011) Kamel Mamchaoui et al.   Skeletal Muscle

Ligand interaction scan (LIScan) in the study of ERK8

(2010) Oran Erster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

An evolutionarily conserved Myostatin proximal promoter/enhancer confers basal levels of transcription and spatial specificity in vivo

(2010) Carla Vermeulen Carvalho Grade et al.   DEVELOPMENT GENES AND EVOLUTION

Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells

(2009) Wei Xie et al.   MOLECULAR CELL

Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle

(2008) Jun Tanihata et al.   JOURNAL OF GENE MEDICINE

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

A rapid micro chromatin immunoprecipitation assay (ChIP)

(2008) John Arne Dahl et al.   Nature Protocols

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

(2008) A. M. Haidet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

(2008) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA