Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

Molecular mechanisms underlying cellular effects of human MEK1 mutations

(2021) Robert A. Marmion et al.   MOLECULAR BIOLOGY OF THE CELL

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AKT and ERK dual inhibitors: The way forward?

(2019) Zhe Cao et al.   CANCER LETTERS

The Rasopathy family: Consequences of germline activation of the RAS/MAPK pathway

(2018) Mylène Tajan et al.   ENDOCRINE REVIEWS

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

(2018) Yijun Gao et al.   Cancer Discovery

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer

(2018) Abbie E. Fearon et al.   Cell Reports

PHLDA1, another PHLDA family protein that inhibits Akt

(2018) Yu Chen et al.   CANCER SCIENCE

The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target

(2018) Karen Flores et al.   NEUROENDOCRINOLOGY

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases

(2018) Merav Ordan et al.   Scientific Reports

BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity

(2017) Caroline M. Emery et al.   MOLECULAR CANCER RESEARCH

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

(2017) Maxwell Z. Wilson et al.   MOLECULAR CELL

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

Divergent effects of intrinsically active MEK variants on developmental Ras signaling

(2017) Yogesh Goyal et al.   NATURE GENETICS

Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome

(2017) Zheng Zhao et al.   PLoS One

The ERK cascade inhibitors: Towards overcoming resistance

(2016) Galia Maik-Rachline et al.   DRUG RESISTANCE UPDATES

Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

(2016) A. Mylona et al.   SCIENCE

Tumor neoantigens: building a framework for personalized cancer immunotherapy

(2015) Matthew M. Gubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF

(2015) J. F. Hechtman et al.   MOLECULAR CANCER RESEARCH

PHLDA2 is a key oncogene-induced negative feedback inhibitor of EGFR/ErbB2 signaling via interference with AKT signaling

(2015) Xiaoqi Wang et al.   Oncotarget

Perinatal features of the RASopathies: Noonan syndrome, Cardiofaciocutaneous syndrome and Costello syndrome

(2014) Angela Myers et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

(2014) Jacob R. Haling et al.   CANCER CELL

Cardio-Facio-Cutaneous Syndrome: Clinical Features, Diagnosis, and Management Guidelines

(2014) M. E. M. Pierpont et al.   PEDIATRICS

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

(2013) A. R. Wasylishen et al.   CANCER RESEARCH

Secretome-Based Identification of TFPI2, A Novel Serum Biomarker for Detection of Ovarian Clear Cell Adenocarcinoma

(2013) Noriaki Arakawa et al.   JOURNAL OF PROTEOME RESEARCH

αC helix displacement as a general approach for allosteric modulation of protein kinases

(2012) Lorenzo Palmieri et al.   DRUG DISCOVERY TODAY

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

(2012) Christoph Meier et al.   JOURNAL OF STRUCTURAL BIOLOGY

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

(2011) Nikhil Wagle et al.   JOURNAL OF CLINICAL ONCOLOGY

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

(2009) Thierry O. Fischmann et al.   BIOCHEMISTRY

MEK1 mutations confer resistance to MEK and B-RAF inhibition

(2009) C. M. Emery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA