The peroxisome: an up-and-coming organelle in immunometabolism

Peroxisomes Are Critical for the Development and Maintenance of B1 and Marginal Zone B Cells but Dispensable for Follicular B Cells and T Cells

(2022) Jonathan Muri et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Acetyltransferase Suppresses Oxidative Stress by Inducing Peroxisome Formation in Macrophages

(2022) Ananyaashree Behera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses

(2022) Anu S. Nath et al.   Cell Reports

Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation

(2022) Dihia Meghnem et al.   Frontiers in Cell and Developmental Biology

The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes

(2022) Yinbo Huo et al.   Communications Biology

Peroxisomes of the Brain: Distribution, Functions, and Associated Diseases

(2021) Rachayeeta Deb et al.   NEUROTOXICITY RESEARCH

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

(2021) Weiwei Cui et al.   CELL DEATH AND DIFFERENTIATION

VPS13D promotes peroxisome biogenesis

(2021) Heather A. Baldwin et al.   JOURNAL OF CELL BIOLOGY

Long Chain Fatty Acids as Modulators of Immune Cells Function: Contribution of FFA1 and FFA4 Receptors

(2021) Maria A. Hidalgo et al.   Frontiers in Physiology

4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages

(2021) Ciana Diskin et al.   JOURNAL OF IMMUNOLOGY

Emerging roles of peroxisomes in viral infections

(2021) Ana Rita Ferreira et al.   TRENDS IN CELL BIOLOGY

Plasmalogens and Chronic Inflammatory Diseases

(2021) José Carlos Bozelli et al.   Frontiers in Physiology

Peroxisomal Membrane Contact Sites in Yeasts

(2021) Amit S. Joshi   Frontiers in Cell and Developmental Biology

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

(2020) Florian J. Weisel et al.   NATURE IMMUNOLOGY

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

(2020) Jinuk Kong et al.   Nature Communications

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

(2020) Ira Tabas et al.   CIRCULATION RESEARCH

TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution

(2020) Yunash Maharjan et al.   EMBO REPORTS

The Swing of Lipids at Peroxisomes and Endolysosomes in T Cell Activation

(2020) Sara G. Dosil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy

(2020) Bettina Zierfuss et al.   Annals of Clinical and Translational Neurology

Peroxisomes in host defense

(2020) Francesca Di Cara   PLoS Pathogens

Peroxisome Metabolism in Cancer

(2020) Jung-Ae Kim   Cells

Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy

(2020) Satoshi Yamashita et al.   Scientific Reports

Innate-adaptive immunity interplay and redox regulation in immune response

(2020) Lizhe Sun et al.   Redox Biology

Overwhelming sepsis in a neonate affected by Zellweger syndrome due to a compound heterozygosis in PEX 6 gene: a case report

(2020) Laura Lucaccioni et al.   BMC Medical Genetics

Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response

(2019) Abhishek Mohanty et al.   Journal of Cell Communication and Signaling

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses

(2019) Jonathan Muri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins

(2019) Jian Xiao et al.   Science China-Life Sciences

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

(2019) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

(2019) Sandra Elizabeth Torres et al.   eLife

Peroxisomes and Oxidative Stress: Their Implications in the Modulation of Cellular Immunity During Mycobacterial Infection

(2019) Geetanjali Ganguli et al.   Frontiers in Microbiology

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors

(2019) Andrea Aloia et al.   CLINICAL CANCER RESEARCH

Peroxisomes in Immune Response and Inflammation

(2019) Francesca Di Cara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prostaglandin regulation of T cell biology

(2019) Damian Maseda et al.   PHARMACOLOGICAL RESEARCH

Effects of Omega-3 Fatty Acids on Immune Cells

(2019) Saray Gutiérrez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

(2019) Jonathan Muri et al.   Cell Reports

The Influence of Dietary Fatty Acids on Immune Responses

(2019) Urszula Radzikowska et al.   Nutrients

Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila

(2018) Kyung-Ah Lee et al.   Cell Host & Microbe

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

(2018) Xiu‐Fei Chen et al.   EMBO REPORTS

Phospholipid signaling in innate immune cells

(2018) Valerie B. O’Donnell et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid Droplets as Immune Modulators in Myeloid Cells

(2018) Martijn H. den Brok et al.   TRENDS IN IMMUNOLOGY

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

(2018) Jonathan Muri et al.   Nature Communications

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

(2018) Nadav Shai et al.   Nature Communications

Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy

(2018) Francesca Di Cara et al.   MOLECULAR BIOLOGY OF THE CELL

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens

(2018) Julio M. Rubio et al.   Frontiers in Immunology

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

(2017) Giada Mondanelli et al.   IMMUNITY

Peroxisome-Mediated Metabolism Is Required for Immune Response to Microbial Infection

(2017) Francesca Di Cara et al.   IMMUNITY

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

Deficiency of Phosphatidylinositol 3-Kinase δ Signaling Leads to Diminished Numbers of Regulatory T Cells and Increased Neutrophil Activity Resulting in Mortality Due to Endotoxic Shock

(2017) Emeka B. Okeke et al.   JOURNAL OF IMMUNOLOGY

A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide

(2017) Vijith Vijayan et al.   JOURNAL OF IMMUNOLOGY

Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis

(2017) Roni Levin et al.   MOLECULAR BIOLOGY OF THE CELL

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation

(2017) Satoshi Fujii et al.   Oncotarget

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

(2017) Elisa Araldi et al.   Cell Reports

Metabolism meets immunity: The role of free fatty acid receptors in the immune system

(2016) Elisa Alvarez-Curto et al.   BIOCHEMICAL PHARMACOLOGY

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human disorders of peroxisome metabolism and biogenesis

(2016) Hans R. Waterham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Omega-3 fatty acids, lipid rafts, and T cell signaling

(2016) Tim Y. Hou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammatory response of TLR4 deficient spleen macrophages (CRL 2471) to Brucella abortus S19 and an isogenic ΔmglA deletion mutant

(2016) Jens Jacob et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Deficiency of a Retinal Dystrophy Protein, Acyl-CoA Binding Domain-containing 5 (ACBD5), Impairs Peroxisomal β-Oxidation of Very-long-chain Fatty Acids

(2016) Yuichi Yagita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

(2016) Daniel W. Beury et al.   JOURNAL OF IMMUNOLOGY

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis

(2016) Jinjiang Fan et al.   MOLECULAR ENDOCRINOLOGY

C13orf31 (FAMIN) is a central regulator of immunometabolic function

(2016) M Zaeem Cader et al.   NATURE IMMUNOLOGY

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

(2016) Jumpei Sasabe et al.   Nature Microbiology

Functional Analyses of the Crohn’s Disease Risk Gene LACC1

(2016) Ghazaleh Assadi et al.   PLoS One

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

(2015) Bei-Bei Chu et al.   CELL

Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability

(2015) Irfan J. Lodhi et al.   Cell Metabolism

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human autoreactive T cells recognize CD1b and phospholipids

(2015) Ildiko Van Rhijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy

(2014) Katharina M. Walter et al.   Cell Metabolism

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Congenic Analysis of the NKT Cell Control Gene Nkt2 Implicates the Peroxisomal Protein Pxmp4

(2014) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

The Intracellular Bacteria Chlamydia Hijack Peroxisomes and Utilize Their Enzymatic Capacity to Produce Bacteria-Specific Phospholipids

(2014) Gaelle Boncompain et al.   PLoS One

Salmonella Evades d-Amino Acid Oxidase To Promote Infection in Neutrophils

(2014) Brian R. Tuinema et al.   mBio

Fatty Acid–Regulated Transcription Factors in the Liver

(2013) Donald B. Jump et al.   Annual Review of Nutrition

Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives

(2013) Nancy E. Braverman et al.   Developmental Disabilities Research Reviews

Endoplasmic Reticulum: An Interface Between the Immune System and Metabolism

(2013) E. R. Unanue et al.   DIABETES

Reductions in neuronal peroxisomes in multiple sclerosis grey matter

(2013) Elizabeth Gray et al.   Multiple Sclerosis Journal

Peroxisomes take shape

(2013) Jennifer J. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

(2013) D. I. Benjamin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty Acids - Induced Lipotoxicity and Inflammation

(2012) Stephane Savary et al.   CURRENT DRUG METABOLISM

Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

(2012) Federica Facciotti et al.   NATURE IMMUNOLOGY

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

In Situ Microscopy Analysis Reveals Local Innate Immune Response Developed around Brucella Infected Cells in Resistant and Susceptible Mice

(2012) Richard Copin et al.   PLoS Pathogens

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Antiinflammatory Effects of Hydrogen Peroxide in Neutrophil Activation and Acute Lung Injury

(2009) Jaroslaw W. Zmijewski et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative Imbalance in Nonstimulated X-Adrenoleukodystrophy-Derived Lymphoblasts

(2009) Takuhiro Uto et al.   DEVELOPMENTAL NEUROSCIENCE

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE