Deficiency of Phosphatidylinositol 3-Kinase δ Signaling Leads to Diminished Numbers of Regulatory T Cells and Increased Neutrophil Activity Resulting in Mortality Due to Endotoxic Shock

In Search of a Cure for Sepsis: Taming the Monster in Critical Care Medicine

(2016) Emeka B. Okeke et al.   Journal of Innate Immunity

Neutrophil CD64 as a Diagnostic Marker of Sepsis in Neonates

(2016) Sanaa Elawady et al.   JOURNAL OF INVESTIGATIVE MEDICINE

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

(2015) Marielle S. Köberlin et al.   CELL

RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection

(2015) Chien-Hsiung Yu et al.   JOURNAL OF IMMUNOLOGY

Natural Naive CD4 + CD25 + CD127 low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

(2014) Koen Venken et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Restrain CD4+T Cells from Causing Unregulated Immune Activation and Hypersensitivity to Lipopolysaccharide Challenge

(2014) Emeka B. Okeke et al.   JOURNAL OF IMMUNOLOGY

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

(2013) Carrie L Lucas et al.   NATURE IMMUNOLOGY

Phosphoinositide 3-Kinase   Gene Mutation Predisposes to Respiratory Infection and Airway Damage

(2013) I. Angulo et al.   SCIENCE

CD4+CD25+ Regulatory T Cells Attenuate Lipopolysaccharide-Induced Systemic Inflammatory Responses and Promotes Survival in Murine Escherichia coli Infection

(2013) Emeka B. Okeke et al.   SHOCK

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response

(2012) Laszlo Nagy et al.   PHYSIOLOGICAL REVIEWS

The inflammatory response in sepsis

(2012) Markus Bosmann et al.   TRENDS IN IMMUNOLOGY

Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice

(2012) John S. Cho et al.   PLoS Pathogens

Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury

(2011) Qing Deng et al.   CELLULAR MICROBIOLOGY

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

(2011) Joel Montane et al.   JOURNAL OF CLINICAL INVESTIGATION

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

(2011) T. D. Troutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Targeting CD44 Expressed on Neutrophils Inhibits Lung Damage in Abdominal Sepsis

(2011) Zirak Hasan et al.   SHOCK

Neutrophils are significant producers of IL-10 during sepsis

(2010) Kevin R. Kasten et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human CD4+FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils

(2010) Megan E. Himmel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophil function in inflammation and inflammatory diseases

(2010) H. L. Wright et al.   RHEUMATOLOGY

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils

(2009) Emily P. Dick et al.   IMMUNOLOGY

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The p110  Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to Leishmania major by Regulating Expansion and Tissue Homing of Regulatory T Cells

(2009) D. Liu et al.   JOURNAL OF IMMUNOLOGY

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

(2008) Todd M. Brusko et al.   IMMUNOLOGICAL REVIEWS