Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration

Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-ɣ): Molecular Effects and Its Importance as a Novel Therapeutic Target for Cerebral Ischemic Injury

(2021) Ashi Mannan et al.   NEUROCHEMICAL RESEARCH

Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration

(2020) Muhammad Imran et al.   Biomolecules

Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats

(2020) Ubaid Ullah et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

NF-κB Inhibitors Attenuate MCAO Induced Neurodegeneration and Oxidative Stress—A Reprofiling Approach

(2020) Awais Ali et al.   Frontiers in Molecular Neuroscience

Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration

(2020) Sumbal Iqbal et al.   Biomolecules

Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration

(2020) Arooj Mohsin Alvi et al.   Biomolecules

Ginkgo biloba Extract Protects against Methotrexate-Induced Hepatotoxicity: A Computational and Pharmacological Approach

(2020) Lina Tariq Al Kury et al.   MOLECULES

Potent Natural Antioxidant Carveol Attenuates MCAO-Stress Induced Oxidative, Neurodegeneration by Regulating the Nrf-2 Pathway

(2020) Imran Malik et al.   Frontiers in Neuroscience

Repurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats

(2020) Zikra Zulfiqar et al.   Journal of Inflammation Research

Molecular Docking: Shifting Paradigms in Drug Discovery

(2019) Luca Pinzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach

(2019) Lina Al Kury et al.   Drug Design Development and Therapy

Mitochondria as a therapeutic target for ischemic stroke

(2019) Zhi He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aggravation of Cerebral Ischemia/Reperfusion Injury by Peroxisome Proliferator-Activated Receptor-Gamma Deficiency via Endoplasmic Reticulum Stress

(2019) Yueping Chen et al.   MEDICAL SCIENCE MONITOR

Pathological Comparisons of the Hippocampal Changes in the Transient and Permanent Middle Cerebral Artery Occlusion Rat Models

(2019) Fawad Ali Shah et al.   Frontiers in Neurology

Interactive structural analysis of βTrCP1 and PER2 phosphoswitch binding through dynamics simulation assay

(2018) Najumuddin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics

(2018) Shagufta Shafique et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach

(2018) Fawad-Ali Shah et al.   NEUROCHEMICAL RESEARCH

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

(2018) Wei Cai et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke

(2017) Stephanie M. Davis et al.   NEUROCHEMISTRY INTERNATIONAL

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need

(2017) Ike dela Peña et al.   Journal of Stroke

Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study

(2017) Saima Younis et al.   PLoS One

PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

(2016) Juan Carlos Corona et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Localization of PPAR isotypes in the adult mouse and human brain

(2016) Anna Warden et al.   Scientific Reports

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Neuroprotection for ischaemic stroke: Current status and challenges

(2015) Antonio Moretti et al.   PHARMACOLOGY & THERAPEUTICS

Proteomic Identification of Proteins Differentially Expressed in Response to Resveratrol Treatment in Middle Cerebral Artery Occlusion Stroke Model

(2014) Fawad-Ali SHAH et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

(2014) Stephen M Strittmatter   NATURE MEDICINE

Role of Inflammation and Its Mediators in Acute Ischemic Stroke

(2013) Rong Jin et al.   Journal of Cardiovascular Translational Research

Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery

(2012) Xuan-Yu Meng et al.   Current Computer-Aided Drug Design

Redox control of NLRP3 inflammasome activation in health and disease

(2012) Anna Rubartelli   JOURNAL OF LEUKOCYTE BIOLOGY

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

(2012) Marcelo Vizoná Liberato et al.   PLoS One

Characterization of new PPARγ agonists: Benzimidazole derivatives—importance of positions 5 and 6, and computational studies on the binding mode

(2010) Matthias Goebel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Mitochondria, oxidative metabolism and cell death in stroke

(2009) Neil R. Sims et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications

(2009) Ramalinga R. Kedika et al.   DIGESTIVE DISEASES AND SCIENCES

PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss

(2009) Gianluca Miglio et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial Targets for Stroke

(2009) Peter S. Vosler et al.   STROKE

Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents

(2008) Amy Hyong et al.   BRAIN RESEARCH