CRISPR-Cas13a cascade-based viral RNA assay for detecting SARS-CoV-2 and its mutations in clinical samples

A warm-start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids

(2022) Xiaolin Wu et al.   ANALYTICA CHIMICA ACTA

Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

(2021) Houriiyah Tegally et al.   NATURE

Hairpin‐Spacer crRNA‐Enhanced CRISPR/Cas13a System Promotes the Specificity of Single Nucleotide Polymorphism (SNP) Identification

(2021) Yuqing Ke et al.   Advanced Science

Cas14a1-mediated Nucleic Acid Detection Platform for Pathogen

(2021) Xiaolin Ge et al.   BIOSENSORS & BIOELECTRONICS

CRISPR-based detection of SARS-CoV-2: A review from sample to result

(2021) Reza Nouri et al.   BIOSENSORS & BIOELECTRONICS

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

(2021) Markus Hoffmann et al.   CELL

Combining tag-specific primer extension and magneto-DNA system for Cas14a-based universal bacterial diagnostic platform

(2021) Fengge Song et al.   BIOSENSORS & BIOELECTRONICS

Sensitive quantitative detection of SARS-CoV-2 in clinical samples using digital warm-start CRISPR assay

(2021) Xiong Ding et al.   BIOSENSORS & BIOELECTRONICS

Droplet Cas12a Assay Enables DNA Quantification from Unamplified Samples at the Single-Molecule Level

(2021) Huahua Yue et al.   NANO LETTERS

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

(2021) Jingsong Zhang et al.   Cell Discovery

Digital CRISPR/Cas12b-based platform enabled absolute quantification of viral RNA

(2021) Xinyi Luo et al.   ANALYTICA CHIMICA ACTA

One-pot pre-coated interface proximity extension assay for ultrasensitive co-detection of anti-SARS-CoV-2 antibodies and viral RNA

(2021) Sijia Yan et al.   BIOSENSORS & BIOELECTRONICS

Sensitive and rapid on-site detection of SARS-CoV-2 using a gold nanoparticle-based high-throughput platform coupled with CRISPR/Cas12-assisted RT-LAMP

(2021) Yaqin Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

CRISPR-Cas12a-Based Detection of SARS-CoV-2 Harboring the E484K Mutation

(2021) María-Carmen Marqués et al.   ACS Synthetic Biology

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Diagnosis of COVID-19: Challenges and Research Needs

(2020) Wei Feng et al.   ANALYTICAL CHEMISTRY

Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay

(2020) Xiong Ding et al.   Nature Communications

Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

(2020) Maturada Patchsung et al.   Nature Biomedical Engineering

An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics

(2020) Tian Tian et al.   ACS Nano

Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology

(2020) Bo Pang et al.   ANALYTICAL CHEMISTRY

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

(2020) Parinaz Fozouni et al.   CELL

Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2

(2020) Jon Arizti-Sanz et al.   Nature Communications

High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity

(2019) Yuanyue Shan et al.   ANALYTICAL CHEMISTRY

Field-deployable viral diagnostics using CRISPR-Cas13

(2018) Cameron Myhrvold et al.   SCIENCE

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a

(2018) Akshay Tambe et al.   Cell Reports

CRISPR Methods for Nucleic Acid Detection Herald the Future of Molecular Diagnostics

(2018) Asma Hatoum-Aslan   CLINICAL CHEMISTRY

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Genetically Encoded Fluorescent RNA Sensor for Ratiometric Imaging of MicroRNA in Living Tumor Cells

(2017) Zhan-Ming Ying et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Fluorescence Imaging of Cellular Metabolites with RNA

(2012) Jeremy S. Paige et al.   SCIENCE

RNA Mimics of Green Fluorescent Protein

(2011) J. S. Paige et al.   SCIENCE

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE