Ketamine induces rapid antidepressant effects via the autophagy-NLRP3 inflammasome pathway

The influence of ketamine’s repeated treatment on brain topology does not suggest an antidepressant efficacy

(2020) Natalia Gass et al.   Translational Psychiatry

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

(2020) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Global Burden of Disease and the Impact of Mental and Addictive Disorders

(2019) Jürgen Rehm et al.   Current Psychiatry Reports

Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus

(2019) Ji-Shi Ye et al.   Oxidative Medicine and Cellular Longevity

Interplay between Mitophagy and inflammasome in Neurological Disorders

(2019) Radhika Kesharwani et al.   ACS Chemical Neuroscience

Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine

(2019) Wenqing Gong et al.   JOURNAL OF AFFECTIVE DISORDERS

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice

(2019) Ji Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ketamine and rapidly acting antidepressants: Breaking the speed of sound or light?

(2018) Michael Berk et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

(2018) Xiaoyan Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sucrose preference test for measurement of stress-induced anhedonia in mice

(2018) Meng-Ying Liu et al.   Nature Protocols

Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis

(2018) Zhi Ye et al.   NEUROPHARMACOLOGY

Administration of Ketamine Causes Autophagy and Apoptosis in the Rat Fetal Hippocampus and in PC12 Cells

(2018) Xinran Li et al.   Frontiers in Cellular Neuroscience

Ketamine induces reactive oxygen species and enhances autophagy in SV-HUC-1 human uroepithelial cells

(2018) Zhengfei Shan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Ketamine may exert antidepressant effects via suppressing NLRP3 inflammasome to upregulate AMPA receptors

(2018) Jia-Mei Li et al.   NEUROPHARMACOLOGY

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

(2017) Wei Zhu et al.   NEUROSCIENCE

Posttraumatic administration of a sub-anesthetic dose of ketamine exerts neuroprotection via attenuating inflammation and autophagy

(2017) C.-Q. Wang et al.   NEUROSCIENCE

A brief history of the development of antidepressant drugs: From monoamines to glutamate.

(2015) Todd M. Hillhouse et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker

(2015) Estibaliz Ampuero et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review

(2014) Gianluca Serafini et al.   Current Neuropharmacology

Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia

(2014) N. Yuan et al.   HAEMATOLOGICA

A Review of the Clinical, Economic, and Societal Burden of Treatment-Resistant Depression: 1996–2013

(2014) David A. Mrazek et al.   PSYCHIATRIC SERVICES

Ketamine Enhances Human Neural Stem Cell Proliferation and Induces Neuronal Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Pathway

(2013) Xiaowen Bai et al.   ANESTHESIA AND ANALGESIA

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder

(2013) Rosana Mota et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

(2013) Ian Mahar et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Treatment-Resistant Depression Increases Health Costs and Resource Utilization

(2013) Beatrice Alinka Lepine et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats

(2011) Jing Wang et al.   ANESTHESIOLOGY

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY