New compounds from heterocyclic amines scaffold with multitarget inhibitory activity on Aβ aggregation, AChE, and BACE1 in the Alzheimer disease

Identification of butyrylcholinesterase and monoamine oxidase B targeted ligands and their putative application in Alzheimer’s treatment: A computational strategy

(2021) Nasimudeen R Jabir et al.   CURRENT PHARMACEUTICAL DESIGN

Ginnalin A Inhibits Aggregation, Reverses Fibrillogenesis, and Alleviates Cytotoxicity of Amyloid β(1–42)

(2020) Qi Fan et al.   ACS Chemical Neuroscience

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

New Insights Into the Pathogenesis of Alzheimer's Disease

(2020) Liyuan Fan et al.   Frontiers in Neurology

Dangerous Liaisons: Tau Interaction with Muscarinic Receptors

(2020) Adrianna Wysocka et al.   Current Alzheimer Research

A series of molecular modeling techniques to reveal selective mechanisms of inhibitors to β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) and β-site amyloid precursor protein cleaving enzyme 2 (BACE2)

(2020) Shipeng Li et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

(2020) Botond Penke et al.   MOLECULES

Cholinergic white matter pathways make a stronger contribution to attention and memory in normal aging than cerebrovascular health and nucleus basalis of Meynert

(2020) Milan Nemy et al.   NEUROIMAGE

Recent updates in the Alzheimer’s disease etiopathology and possible treatment approaches: a narrative review of current clinical trials

(2020) Elahe Zarini-Gakiye et al.   Current Molecular Pharmacology

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

(2020) Judite R. M. Coimbra et al.   Biomolecules

The Microbiota–Gut–Brain Axis–Heart Shunt Part II: Prosaic Foods and the Brain–Heart Connection in Alzheimer Disease

(2020) Mark Obrenovich et al.   Microorganisms

In silico screening of glycogen synthase kinase-3β targeted ligands against acetylcholinesterase and its probable relevance to Alzheimer’s disease

(2020) Nasimudeen R. Jabir et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The Vexing Complexity of the Amyloidogenic Pathway

(2019) Manuel A. Castro et al.   PROTEIN SCIENCE

Solvent Composition Effects on the Structural Properties of the Aβ42 Monomer from the 3D-RISM-KH Molecular Theory of Solvation

(2019) Nikolay Blinov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The role of mitochondrial defects and oxidative stress in Alzheimer’s disease

(2019) Badar ul Islam et al.   JOURNAL OF DRUG TARGETING

Target Enzyme in Alzheimer’s Disease:Acetylcholinesterase Inhibitors

(2019) Mridula Saxena et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease

(2019) Jun Mo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer’s Disease

(2018) Kanzal Iman et al.   CNS & Neurological Disorders-Drug Targets

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

(2018) Nasimudeen R. Jabir et al.   CNS Neuroscience & Therapeutics

Management of Alzheimer’s disease—An insight of the enzymatic and other novel potential targets

(2017) Badar ul Islam et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Multi-structure docking analysis of BACE1 crystal structures and non-peptidic ligands

(2017) Zahra Haghighijoo et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Acetylcholinesterase: A Primary Target for Drugs and Insecticides

(2017) Sunita Thapa et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer's disease therapy

(2017) Luca Piemontese et al.   Neural Regeneration Research

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations

(2016) Maricarmen Hernández-Rodríguez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapies for Prevention and Treatment of Alzheimer’s Disease

(2016) J. Mendiola-Precoma et al.   Biomed Research International

Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ1–42

(2015) Maricarmen Hernández-Rodríguez et al.   PLoS One

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

(2014) Hongmei Li et al.   Molecular Neurodegeneration

In Vitro Effect of H2O2, Some Transition Metals and Hydroxyl Radical Produced Via Fenton and Fenton-Like Reactions, on the Catalytic Activity of AChE and the Hydrolysis of ACh

(2014) Armando Méndez-Garrido et al.   NEUROCHEMICAL RESEARCH

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

In silicoandin vitrostudies to elucidate the role of Cu2+and galanthamine as the limiting step in the amyloid beta (1-42) fibrillation process

(2013) Maricarmen Hernández-Rodríguez et al.   PROTEIN SCIENCE

Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

(2013) Jonah Cheung et al.   ACS Medicinal Chemistry Letters

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Current therapeutic targets for the treatment of Alzheimer’s disease

(2010) Joshua D Grill et al.   Expert Review of Neurotherapeutics