Primary Cilia and Intraflagellar Transport Proteins in Bone and Cartilage

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex

(2016) Michael Taschner et al.   EMBO JOURNAL

Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism

(2016) Julia C. Chen et al.   FASEB JOURNAL

Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex

(2016) Yohei Katoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFT88 influences chondrocyte actin organization and biomechanics

(2016) Z. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes

(2016) Z. He et al.   OSTEOARTHRITIS AND CARTILAGE

Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

(2016) Xue Yuan et al.   Nature Communications

Cilia Ift protein and motor -related bone diseases and mouse models

(2015) Shuying Yang   Frontiers in Bioscience-Landmark

Cell cycle deregulation and mosaic loss ofExt1drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency

(2015) Carlos E de Andrea et al.   JOURNAL OF PATHOLOGY

Physiological mechanisms and therapeutic potential of bone mechanosensing

(2015) Zhousheng Xiao et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation

(2015) Xue Yuan et al.   PLoS One

Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton

(2014) Xue Yuan et al.   Annals of the New York Academy of Sciences

Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow

(2014) Thomas R. Coughlin et al.   CALCIFIED TISSUE INTERNATIONAL

The growth plate’s response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium

(2014) Yoach Rais et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Primary Cilia Integrate Hedgehog and Wnt Signaling during Tooth Development

(2014) B. Liu et al.   JOURNAL OF DENTAL RESEARCH

The chondrocyte primary cilium

(2014) R. Ruhlen et al.   OSTEOARTHRITIS AND CARTILAGE

IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways

(2013) Changdong Wang et al.   EXPERIMENTAL CELL RESEARCH

Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts

(2013) Robin M. Delaine-Smith et al.   FASEB JOURNAL

Evc Regulates a Symmetrical Response to Shh Signaling in Molar Development

(2013) M. Nakatomi et al.   JOURNAL OF DENTAL RESEARCH

The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis

(2012) Shuying Yang et al.   BONE

Emerging role of primary cilia as mechanosensors in osteocytes

(2012) An M. Nguyen et al.   BONE

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

(2012) A. K. T. Wann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ift88 regulates Hedgehog signaling,Sfrp5expression, and β-catenin activity in post-natal growth plate

(2012) Ching-Fang Chang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Centrosome Fine Ultrastructure of the Osteocyte Mechanosensitive Primary Cilium

(2012) R.E. Uzbekov et al.   MICROSCOPY AND MICROANALYSIS

Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes

(2012) L Ho et al.   ONCOGENE

Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base

(2011) María Pacheco et al.   BONE

Architecture and function of IFT complex proteins in ciliogenesis

(2011) Michael Taschner et al.   DIFFERENTIATION

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia

(2011) Suzanne Rix et al.   HUMAN MOLECULAR GENETICS

Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 cells

(2011) Ni Qiu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells

(2011) C. Martínez et al.   JOURNAL OF DENTAL RESEARCH

Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis

(2011) C.-F. Chang et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanical loading modulates chondrocyte primary cilia incidence and length

(2010) Susan R McGlashan et al.   CELL BIOLOGY INTERNATIONAL

Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

(2010) Ronald Y. Kwon et al.   FASEB JOURNAL

Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma

(2010) Carlos E de Andrea et al.   LABORATORY INVESTIGATION

Kif3a Deficiency Reverses the Skeletal Abnormalities in Pkd1 Deficient Mice by Restoring the Balance Between Osteogenesis and Adipogenesis

(2010) Ni Qiu et al.   PLoS One

Primary cilia regulate Shh activity in the control of molar tooth number

(2009) A. Ohazama et al.   DEVELOPMENT

Conditional Disruption ofPkd1in Osteoblasts Results in Osteopenia Due to Direct Impairment of Bone Formation

(2009) Zhousheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet-Biedl syndrome mutant mice

(2009) Anjan P. Kaushik et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Regulation of chondrogenesis and chondrocyte differentiation by stress

(2008) Michael J. Zuscik et al.   JOURNAL OF CLINICAL INVESTIGATION