PLAA suppresses ovarian cancer metastasis via METTL3-mediated m6A modification of TRPC3 mRNA

Cancer Statistics, 2021

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m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

(2021) Dan Jin et al.   Journal of Hematology & Oncology

Exosome-mediated transfer of CD44 from high-metastatic ovarian cancer cells promotes migration and invasion of low-metastatic ovarian cancer cells

(2021) Xiameng Shen et al.   Journal of Ovarian Research

Advances in TRP channel drug discovery: from target validation to clinical studies

(2021) Ari-Pekka Koivisto et al.   NATURE REVIEWS DRUG DISCOVERY

METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246

(2021) Xuehan Bi et al.   Cell Death Discovery

TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway

(2021) Da-Cen Lin et al.   CANCER LETTERS

The role of Ubiquitination in Apoptosis and Necroptosis

(2021) Jamie Z. Roberts et al.   CELL DEATH AND DIFFERENTIATION

Primary and metastatic peritoneal surface malignancies

(2021) Delia Cortés-Guiral et al.   Nature Reviews Disease Primers

The multicellular signalling network of ovarian cancer metastases

(2021) Leah Sommerfeld et al.   Clinical and Translational Medicine

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

(2020) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

(2020) Hongbo Wang et al.   PHARMACOLOGY & THERAPEUTICS

Molecular Mechanisms Driving mRNA Degradation by m6A Modification

(2020) Yujin Lee et al.   TRENDS IN GENETICS

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

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Reading, writing and erasing mRNA methylation

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METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

(2019) Ben Yue et al.   Molecular Cancer

Ovarian cancer statistics, 2018

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Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells.

(2018) Eloise M Grasset et al.   CANCER RESEARCH

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line

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TRPC3-mediated Ca2+ signals as a promising strategy to boost therapeutic angiogenesis in failing hearts: The role of autologous endothelial colony forming cells

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Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy

(2016) Tzipora C. Falik Zaccai et al.   BRAIN

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

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Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer

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Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Involvement of TRPC Channels in Lung Cancer Cell Differentiation and the Correlation Analysis in Human Non-Small Cell Lung Cancer

(2013) Hong-Ni Jiang et al.   PLoS One

The histone variant MacroH2A regulates Ca2+ influx through TRPC3 and TRPC6 channels

(2013) J-M Kim et al.   Oncogenesis

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism

(2010) E. Baljinnyam et al.   CANCER RESEARCH

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

(2010) Natasha Pashkova et al.   MOLECULAR CELL

Transient receptor potential channel C3 contributes to the progression of human ovarian cancer

(2009) S L Yang et al.   ONCOGENE