How high‐fat diet affects bone in mice: A systematic review and meta‐analysis

Inflammation in obesity, diabetes, and related disorders

(2022) Theresa V. Rohm et al.   IMMUNITY

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

(2022) Chrysoula Boutari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Historical and cultural aspects of obesity: From a symbol of wealth and prosperity to the epidemic of the 21st century

(2022) Marta Sumińska et al.   Obesity Reviews

Osteoporosis in 2022: Care gaps to screening and personalised medicine

(2022) Elizabeth M. Curtis et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Interleukin-6 Knockout Inhibits Senescence of Bone Mesenchymal Stem Cells in High-Fat Diet-Induced Bone Loss

(2021) Yujue Li et al.   Frontiers in Endocrinology

Distinct Effects of a High Fat Diet on Bone in Skeletally Mature and Developing Male C57BL/6J Mice

(2021) Dean S. Ross et al.   Nutrients

RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss

(2021) Yan Hu et al.   EMBO REPORTS

FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice

(2021) Zheng Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

(2021) Anne-Frédérique Turcotte et al.   PLoS One

Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss

(2021) Bingyang Dai et al.   Bioactive Materials

Obesity and Bone: A Complex Relationship

(2021) Giuseppe Rinonapoli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis

(2020) Jiao Li et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Erythropoietin-Induced Changes in Bone and Bone Marrow in Mouse Models of Diet-Induced Obesity

(2020) Sukanya Suresh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decreasing the Ratio of Dietary Linoleic to α-Linolenic Acid from 10 to 4 by Changing Only the Former Does Not Prevent Adiposity or Bone Deterioration in Obese Mice

(2020) Jay J Cao et al.   JOURNAL OF NUTRITION

At the Crossroads of the Adipocyte and Osteoclast Differentiation Programs: Future Therapeutic Perspectives

(2020) Shanmugam Muruganandan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Bones of Children With Obesity

(2020) Danilo Fintini et al.   Frontiers in Endocrinology

Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model

(2020) Deepak Kumar Khajuria et al.   BONE

Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis

(2020) M. Leonor Fernández-Murga et al.   BONE

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

(2020) Brittany A. Eckhardt et al.   JCI Insight

Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss

(2020) Wei Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice

(2019) Matthew J Silva et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity

(2019) Lauren Votava et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Body Fat Percentage, Body Mass Index, Fat Mass Index and the Ageing Bone: Their Singular and Combined Roles Linked to Physical Activity and Diet

(2019) David Tomlinson et al.   Nutrients

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice

(2019) Sity Aishah Mansur et al.   Frontiers in Endocrinology

Glucocorticoid aggravates bone micro-architecture deterioration and skeletal muscle atrophy in mice fed on high-fat diet

(2019) Sulekha Adhikary et al.   STEROIDS

Mechanisms Involved in Childhood Obesity-Related Bone Fragility

(2019) Maria Felicia Faienza et al.   Frontiers in Endocrinology

Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet

(2019) Jordan E. Bisanz et al.   Cell Host & Microbe

Increasing Dietary Fish Oil Reduces Adiposity and Mitigates Bone Deterioration in Growing C57BL/6 Mice Fed a High-Fat Diet

(2019) Jay J Cao et al.   JOURNAL OF NUTRITION

Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice

(2019) Naoyuki Kawao et al.   PLoS One

Skeletal muscle adiponectin induction in obesity and exercise

(2019) Sergio F. Martinez-Huenchullan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia in vivo

(2018) Yanmao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice

(2018) Laura R. McCabe et al.   BONE

Differential effects of high-fat diet and exercise training on bone and energy metabolism

(2018) Ann-Kristin Picke et al.   BONE

High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

(2018) James G. Burchfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fat diet disrupts bone remodeling by inducing local and systemic alterations

(2018) Carina Cristina Montalvany-Antonucci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling

(2018) Md Mizanur Rahman et al.   Oxidative Medicine and Cellular Longevity

A High-Fat Diet Decreases Bone Mass in Growing Mice with Systemic Chronic Inflammation Induced by Low-Dose, Slow-Release Lipopolysaccharide Pellets

(2017) Jay J Cao et al.   JOURNAL OF NUTRITION

Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL/6J mice

(2017) Kirsten N. Bott et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reduced femoral bone mass in both diet-induced and genetic hyperlipidemia mice

(2016) Xiang Chen et al.   BONE

Obesity does not affect the healing of femur fractures in mice

(2016) T. Histing et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

An isoflavone cladrin prevents high-fat diet-induced bone loss and inhibits the expression of adipogenic gene regulators in 3T3-L1 adipocyte

(2016) Jyoti Gautam et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

(2016) Anil Bhatta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanisms of diabetes mellitus-induced bone fragility

(2016) Nicola Napoli et al.   Nature Reviews Endocrinology

A high-fat diet increases body weight and circulating estradiol concentrations but does not improve bone structural properties in ovariectomized mice

(2016) Jay J. Cao et al.   NUTRITION RESEARCH

Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice

(2015) Yuxu Feng et al.   BRITISH JOURNAL OF NUTRITION

Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice

(2015) Eric E. Beier et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Metabolic and structural bone disturbances induced by hyperlipidic diet in mice treated with simvastatin

(2015) Evelise Aline Soares et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Bone Density, Microstructure and Strength in Obese and Normal Weight Men and Women in Younger and Older Adulthood

(2015) Amy L Evans et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice

(2015) Casey R. Doucette et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A direct role of collagen glycation in bone fracture

(2015) Atharva A. Poundarik et al.   Journal of the Mechanical Behavior of Biomedical Materials

Soy protein is beneficial but high-fat diet and voluntary running are detrimental to bone structure in mice

(2015) Lin Yan et al.   NUTRITION RESEARCH

The Effects of a High Fat Diet Containing Diacylglycerol on Bone in C57BL/6J Mice

(2015) Han Seok Choi et al.   YONSEI MEDICAL JOURNAL

Indirubin-3′-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice

(2014) Muhammad Zahoor et al.   BONE

Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise

(2014) Maya Styner et al.   BONE

Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity

(2014) Alexander Bartelt et al.   BONE

Micro-architectural changes in cancellous bone differ in female and male C57BL/6 mice with high-fat diet-induced low bone mineral density

(2014) Jyoti Gautam et al.   BRITISH JOURNAL OF NUTRITION

TNF-α Upregulates Sclerostin Expression in Obese Mice Fed a High-Fat Diet

(2014) Kyunghwa Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

N-Acetylcysteine Supplementation Decreases Osteoclast Differentiation and Increases Bone Mass in Mice Fed a High-Fat Diet

(2014) Jay J. Cao et al.   JOURNAL OF NUTRITION

Fracture mortality: associations with epidemiology and osteoporosis treatment

(2014) Sebastian E. Sattui et al.   Nature Reviews Endocrinology

Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture

(2014) Hinrich Fehrendt et al.   International Journal of Endocrinology

Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur

(2013) Jason A. Inzana et al.   BONE

Trends in Fracture Incidence: A Population-Based Study Over 20 Years

(2013) Shreyasee Amin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A high-fat diet induces obesity and impairs bone acquisition in young male mice

(2013) XIAO-MEI LU et al.   Molecular Medicine Reports

Overweight and obesity are associated with musculoskeletal complaints as early as childhood: a systematic review

(2013) W. D. Paulis et al.   Obesity Reviews

Hypercholesterolemia Promotes an Osteoporotic Phenotype

(2012) Kristine Pelton et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice

(2012) Dae Ho Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bone Metabolism in Obesity and Weight Loss

(2012) Sue A. Shapses et al.   Annual Review of Nutrition

Effects of local insulin delivery on subperiosteal angiogenesis and mineralized tissue formation during fracture healing

(2012) David N. Paglia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Adverse effects of hyperlipidemia on bone regeneration and strength

(2011) Flavia Pirih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet

(2011) Ying Xiao et al.   NUTRITION RESEARCH

Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: Modulation by diet-induced obesity

(2010) Alexander Bartelt et al.   BONE

Racial differences in pre- and postmenopausal bone homeostasis: Association with bone density

(2010) Diane E. Meier et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased bone resorption and impaired bone microarchitecture in short-term and extended high-fat diet–induced obesity

(2010) Janina M. Patsch et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity

(2009) S.S. Ionova-Martin et al.   BONE