Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair

(2020) Yasuhito Yahara et al.   NATURE CELL BIOLOGY

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

(2020) Yuki Matsushita et al.   Nature Communications

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

(2020) Leilei Zhong et al.   eLife

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

(2019) Ninib Baryawno et al.   CELL

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths

(2019) Samuel L. Wolock et al.   Cell Reports

EZH2 supports osteoclast differentiation and bone resorption via epigenetic and cytoplasmic targets

(2019) Juraj Adamik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

(2019) Andrew Ying Hui Ng et al.   eLife

Recent advances in osteoclast biology

(2018) Takehito Ono et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

(2018) Jinhu Xiong et al.   Nature Communications

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Digesting the role of bone marrow macrophages on hematopoiesis

(2017) Esther Heideveld et al.   IMMUNOBIOLOGY

Cre Recombinase Strains Used for the Study of Adipose Tissues and Adipocyte Progenitors

(2017) Jiaqi Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice

(2016) Yuko Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms

(2016) Abhishek Chandra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Marrow Adipose Tissue: To Be or Not To Be a Typical Adipose Tissue?

(2016) Pierre Hardouin et al.   Frontiers in Endocrinology

Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss

(2015) X Yuan et al.   CELL DEATH AND DIFFERENTIATION

Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis

(2015) Nathaniel A. Dyment et al.   DEVELOPMENTAL BIOLOGY

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL

(2014) Sunao Takeshita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators

(2014) Vance Holt et al.   PLoS One

RANKL subcellular trafficking and regulatory mechanisms in osteocytes

(2013) Masashi Honma et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage

(2012) René Huber et al.   CELLULAR SIGNALLING

Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss

(2012) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression

(2011) Hisataka Goto et al.   BIOMEDICAL RESEARCH-TOKYO

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Primary human bone marrow adipocytes support TNF-α-induced osteoclast differentiation and function through RANKL expression

(2011) Hisataka Goto et al.   CYTOKINE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

The Critical Role of IL-34 in Osteoclastogenesis

(2011) Zhi Chen et al.   PLoS One

Efficient osteoclast differentiation requires local complement activation

(2010) Z. Tu et al.   BLOOD

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Mechanism of Osteoclast Differentiation Induced by IL-1

(2009) J. H. Kim et al.   JOURNAL OF IMMUNOLOGY

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

High-Mobility Group Box Proteins Modulate Tumor Necrosis Factor-α Expression in Osteoclastogenesis via a Novel Deoxyribonucleic Acid Sequence

(2008) Kosj Yamoah et al.   MOLECULAR ENDOCRINOLOGY

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY