P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica

A new form of axonal pathology in a spinal model of neuromyelitis optica

(2022) Marina Herwerth et al.   BRAIN

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

(2021) Wanchao Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody

(2020) Romana Höftberger et al.   ACTA NEUROPATHOLOGICA

Novel insights into pathophysiology and therapeutic possibilities reveal further differences between AQP4-IgG- and MOG-IgG-associated diseases

(2020) Simone Mader et al.   CURRENT OPINION IN NEUROLOGY

Emerging treatments for neuromyelitis optica spectrum disorder

(2020) Ray Wynford-Thomas et al.   JOURNAL OF NEUROLOGY

Clinical commentary on the broadening spectrum of myelin oligodendrocyte glycoprotein–associated disorder (MOGAD)

(2020) Sara Collorone et al.   Multiple Sclerosis Journal

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

(2019) Sean J. Pittock et al.   NEW ENGLAND JOURNAL OF MEDICINE

100 Years of Suramin

(2019) Natalie Wiedemar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Suramin is a novel competitive antagonist selective to α1β2γ2 GABAA over ρ1 GABAC receptors

(2018) Hui Luo et al.   NEUROPHARMACOLOGY

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology

(2016) Marina Herwerth et al.   ANNALS OF NEUROLOGY

Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediated mesangial cell lysis

(2016) Honglan Piao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins

(2016) Simone M. Brändle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

(2015) Dean M. Wingerchuk et al.   NEUROLOGY

Interaction of different prototropic species of an anticancer drug ellipticine with HSA and IgG proteins: multispectroscopic and molecular modeling studies

(2015) Raina Thakur et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Neuromyelitis optica: clinical features, immunopathogenesis and treatment

(2014) S. Jarius et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo

(2014) Philip R. Williams et al.   Nature Communications

Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions

(2013) Claudia Wrzos et al.   ACTA NEUROPATHOLOGICA

Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida

(2013) Hiroaki Iwata et al.   EXPERIMENTAL DERMATOLOGY

Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes

(2013) Elisa Romanelli et al.   Nature Protocols

Topical Application of PPADS Inhibits Complement Activation and Choroidal Neovascularization in a Model of Age-Related Macular Degeneration

(2013) Kerstin Birke et al.   PLoS One

A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis

(2013) Peter Babokhov et al.   Pathogens and Global Health

T cell-activation in neuromyelitis optica lesions plays a role in their formation

(2013) Maria Pohl et al.   Acta Neuropathologica Communications

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

The P2 Receptor Antagonist PPADS Supports Recovery from Experimental Stroke In Vivo

(2011) Alexandra B. Lämmer et al.   PLoS One

Quantification and Functional Characterization of Antibodies to Native Aquaporin 4 in Neuromyelitis Optica

(2010) Sudhakar Reddy Kalluri et al.   ARCHIVES OF NEUROLOGY

Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure☆

(2010) Alena Janda et al.   MOLECULAR IMMUNOLOGY

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

(2010) Sven Jarius et al.   Nature Reviews Neurology

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Possible involvement of PPARγ in the regulation of basal channel opening of P2X7 receptor in cultured mouse astrocytes

(2009) Kazuki Nagasawa et al.   LIFE SCIENCES

Increase of intracellular Ca2+ by P2X and P2Y receptor-subtypes in cultured cortical astroglia of the rat

(2009) W. Fischer et al.   NEUROSCIENCE

 -Hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis

(2009) M. Skals et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling in inflammation of the central nervous system

(2009) Francesco Di Virgilio et al.   TRENDS IN NEUROSCIENCES

P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes

(2008) U. Lalo et al.   JOURNAL OF NEUROSCIENCE

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES

Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy

(2007) Dimitrios Davalos et al.   JOURNAL OF NEUROSCIENCE METHODS