Article
Ophthalmology
Jae Yong Park, Min-Ji Kang, Bum Gi Kim, Kyu Ho Chung, Ha Eun Sim, Seong Woo Lee, Jae Suk Kim, Hyeon Seok Lee, Je Hyung Hwang
Summary: The study found that during the development of CNV, there is a significant increase in choroidal thickness in the corresponding subfield. Additionally, three months before the development of CNV, the choroidal thickness in the central subfield also significantly increases. Regular measurement of choroidal thickness may help in predicting CNV development.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Gideon Obasanmi, Matthew R. Zeglinski, Ella Hardie, Anna-Catharina Wilhelm, Christopher T. Turner, Sho Hiroyasu, Wendy A. Boivin, Yuan Tian, Hongyan Zhao, Eleanor To, Jing Z. Cui, Jeanne Xi, Hyung-Suk Yoo, Manjosh Uppal, David J. Granville, Joanne A. Matsubara
Summary: Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in the elderly and is associated with abnormal blood vessel growth. This study explored the relationship between the protease Granzyme B (GzmB) and the antiangiogenic factors Thrombospondin (TSP)-1 and TSP-2 in eyes with neovascular AMD. The study found that TSP-1 and TSP-2 are substrates of GzmB and that the proteolysis of these factors by GzmB may contribute to neovascular AMD-related choroidal neovascularization (CNV).
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Andrea P. Cabrera, Jonathan Stoddard, Irene Santiago Tierno, Nikolaos Matisioudis, Mahesh Agarwal, Lauren Renner, Neha Palegar, Martha Neuringer, Trevor McGill, Kaustabh Ghosh
Summary: The study found differences in the characteristics of choroidal endothelial cells in young and old monkey eyes, with cells in older eyes being stiffer and more susceptible to complement activation-induced damage. These differences may be related to the activities of the mechanical structure regulators Rac and Rho in the cells. These findings offer new mechanistic insights into choroidal vascular loss in early AMD and warrant further investigation for translational potential.
JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
Summary: This study found that anti-vascular endothelial growth factor (VEGF) therapy can lead to changes in the complement system in eyes with age-related choroidal neovascularization (CNV), including significant increases in C3a and C4a levels. However, these changes did not impact visual outcomes in the eyes with CNV.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Aniket Ramshekar, Haibo Wang, M. Elizabeth Hartnett
Summary: AMD is a major cause of blindness worldwide, with neovascular AMD leading to vision loss. The current standard of care with anti-angiogenic agents is only effective in around 50% of AMD cases. Studies have shown that Rac1 activation plays a crucial role in the invasion of choroidal endothelial cells into the neural retina in AMD.
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Daniel Duck-Jin Hwang, Seong Choi, Junseo Ko, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Hak Jun Lee, Joonhong Sohn, Kyu Hyung Park, Jinyoung Han
Summary: This study successfully distinguished between RAP and PCV cases in neovascular age-related macular degeneration using a deep learning model, showing high accuracy, sensitivity, and specificity. The novel model performed well in distinguishing between PCV and RAP, demonstrating better diagnostic performance than other models and comparable performance with ophthalmologists.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
I-Chia Liang, Wen-Chin Ko, Yu-Jou Hsu, Yi-Ru Lin, Yun-Hsiang Chang, Xv-Hui Zong, Pei-Chen Lai, Der-Chen Chang, Chi-Feng Hung
Summary: The experiment demonstrated that H-2 inhalation could significantly alleviate CNV leakage in a mouse model of CNV, possibly through suppression of the inflammatory process and VEGF-driven CNV formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim
Summary: This study investigated the incidence, risk factors, and impact on visual outcomes of SRH in patients with nAMD and PCV who discontinued treatment. SRH development led to poor visual prognosis in those who stopped treatment, and type 3 MNV had a relatively high risk of SRH occurrence.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Jae-Hui Kim, Jong-Woo Kim, Chul-Gu Kim
Summary: This study revealed a trend in the selection of ranibizumab and aflibercept for initial treatment of neovascular AMD and PCV, with ranibizumab preferred in older patients and those with type 3 MNV, and aflibercept highly preferred in patients with PCV. The variance in patient characteristics and efficacy of the two agents may have influenced this trend.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Summary: This study investigated the effect of ageing on subretinal fibrosis secondary to choroidal neovascularization and the mechanism of action. The results showed that ageing increased the number of circulating fibrocytes and the profibrotic potential of BM-derived macrophages. Additionally, aged mice had significantly more severe subretinal fibrosis compared to young mice. The transplantation of BM from aged mice significantly increased subretinal fibrosis in young mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Pengxiang Zhou, Siqian Zheng, Ente Wang, Peng Men, Suodi Zhai
Summary: Conbercept is well-tolerated and effective in improving vision and fundus condition in patients with neovascular age-related macular degeneration and diabetic macular edema compared with laser photocoagulation, intravitreal triamcinolone acetonide, and placebo. Further large-sample and long-term studies are needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mayank Choubey, Puran Bora
Summary: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in adults, with significant visual disability and central vision loss. Adiponectin (APN) and its receptors (AdipoRs) play a central role in metabolic disorders and ocular pathology. This review summarizes the association of APN/AdipoRs with retinal diseases, specifically AMD and diabetic retinopathy, and presents original research on the inhibition of choroidal neovascularization (CNV) in a mouse model with APN-derived peptides.
Article
Chemistry, Multidisciplinary
Siva P. Kambhampati, Imran A. Bhutto, Tony Wu, Katie Ho, D. Scott McLeod, Gerard A. Lutty, Rangaramanujam M. Kannan
Summary: The study demonstrates a potential systemic therapy approach for selectively targeting and inhibiting the progression of AMD, showing promising efficacy in animal models and human postmortem studies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, General & Internal
Tianxi Wang, Pingzhu Zhou, Xuemei Xie, Yohei Tomita, Steve Cho, Demetrios Tsirukis, Enton Lam, Hongbo Robert Luo, Ye Sun
Summary: The study revealed that myeloid lineage cells played a significant role in regulating pathological CNV formation via SOCS3, as demonstrated in mouse models.
Article
Ophthalmology
Derek Leaderer, Siobhan M. Cashman, Rajendra Kumar-Singh
EXPERIMENTAL EYE RESEARCH
(2015)
Article
Biotechnology & Applied Microbiology
Derek Leaderer, Siobhan M. Cashman, Rajendra Kumar-Singh
JOURNAL OF GENE MEDICINE
(2015)
Article
Biotechnology & Applied Microbiology
Siobhan M. Cashman, Jessica Gracias, Mehreen Adhi, Rajendra Kumar-Singh
JOURNAL OF GENE MEDICINE
(2015)
Article
Ophthalmology
Derek Leaderer, Siobhan M. Cashman, Rajendra Kumar-Singh
EXPERIMENTAL EYE RESEARCH
(2016)
Article
Medicine, Research & Experimental
Bhanu Chandar Dasari, Siobhan M. Cashman, Rajendra Kumar-Singh
MOLECULAR THERAPY-NUCLEIC ACIDS
(2017)
Article
Ophthalmology
Deepa Talreja, Siobhan M. Cashman, Bhanu Dasari, Binit Kumar, Rajendra Kumar-Singh
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Binit Kumar, Siobhan M. Cashman, Rajendra Kumar-Singh
Article
Biochemistry & Molecular Biology
J. M. K. Kwong, L. Gu, N. Nassiri, V. Bekerman, R. Kumar-Singh, K. D. Rhee, X-J Yang, W. W. Hauswirth, J. Caprioli, N. Piri
Article
Biochemistry & Molecular Biology
M. T. Birke, E. Lipo, M. Adhi, K. Birke, R. Kumar-Singh
Article
Biochemistry & Molecular Biology
Shan-Xue Jin, Junko Arai, Xuejun Tian, Rajendra Kumar-Singh, Larry A. Feig
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Shan-Xue Jin, Christopher Bartolome, Junko A. Arai, Laurel Hoffman, B. Gizem Uzturk, Rajendra Kumar-Singh, M. Neal Waxham, Larry A. Feig
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Ophthalmology
Rajendra Kumar-Singh
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Ophthalmology
Erion Lipo, Siobhan M. Cashman, Rajendra Kumar-Singh
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)